Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03-31

AUTHORS

Farhad Forouhar, Simon Arragain, Mohamed Atta, Serge Gambarelli, Jean-Marie Mouesca, Munif Hussain, Rong Xiao, Sylvie Kieffer-Jaquinod, Jayaraman Seetharaman, Thomas B Acton, Gaetano T Montelione, Etienne Mulliez, John F Hunt, Marc Fontecave

ABSTRACT

Methylthiolation by radical SAM enzymes is thought to include the sacrificial breakdown of a second Fe-S cluster to generate the sulfur cosubstrate. A biochemical, spectroscopic and structural study of two methylthiotransferases shows these enzymes retain their clusters, using exogenous thiols to modify their targets.

PAGES

333-338

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1229

DOI

http://dx.doi.org/10.1038/nchembio.1229

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008080634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23542644


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