Combining acid–base, redox and substrate binding functionalities to give a complete model for the [FeFe]-hydrogenase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

James M. Camara, Thomas B. Rauchfuss

ABSTRACT

Some enzymes function by coupling substrate turnover with electron transfer from a redox cofactor such as ferredoxin. In the [FeFe]-hydrogenases, nature's fastest catalysts for the production and oxidation of H(2), the one-electron redox by a ferredoxin complements the one-electron redox by the diiron active site. In this Article, we replicate the function of the ferredoxins with the redox-active ligand Cp*Fe(C(5)Me(4)CH(2)PEt(2)) (FcP*). FcP* oxidizes at mild potentials, in contrast to most ferrocene-based ligands, which suggests that it might be a useful mimic of ferredoxin cofactors. The specific model is Fe(2)[(SCH(2))(2)NBn](CO)(3)(FcP*)(dppv) (1), which contains the three functional components of the active site: a reactive diiron centre, an amine as a proton relay and, for the first time, a one-electron redox module. By virtue of the synthetic redox cofactor, [1](2+) exhibits unique reactivity towards hydrogen and CO. In the presence of excess oxidant and base, H(2) oxidation by [1](2+) is catalytic. More... »

PAGES

26

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchem.1180

DOI

http://dx.doi.org/10.1038/nchem.1180

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030937816

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22169868


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nchem.1180'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nchem.1180'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nchem.1180'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nchem.1180'


 

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