PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-04

AUTHORS

Johanna Ivaska, Lisardo Bosca, Peter J. Parker

ABSTRACT

The critical dependence of receptor-triggered signals on integrin-mediated cell-substrate interactions represents a fundamental biological paradigm in health and disease. However, the molecular connections of these permissive inputs, which operate through integrin-matrix interactions, has remained largely obscure. Here we show that the serine-threonine kinase protein kinase C epsilon (PKCepsilon) functions as a signal integrator between cytokine and integrin signalling pathways. Integrins are shown to control PKCepsilon phosphorylation acutely by determining complex formation with protein phosphatase 2A (PP2A) and the upstream kinase PDK1 (phosphoinositide-dependent kinase 1). The PP2A-induced loss of PKCepsilon function results in attenuated interferon gamma (INF-gamma)-induced phosphorylation of STAT1 (signal transducer and activator of transcription 1) downstream of Janus kinase 1/2 (JAK1/2). PKCepsilon function and the IFN-gamma response can be recovered by inhibition of PP2A if PDK1 is associated with PKCepsilon in this complex. More directly, a PP2A-resistant mutant of PKCepsilon is sufficient for restoration of the IFN-gamma response in suspension culture. Thus, PKCepsilon functions as a central point of integration through which integrin engagement exerts a permissive input on IFN-gamma signalling. More... »

PAGES

363-369

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb957

DOI

http://dx.doi.org/10.1038/ncb957

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000836815

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12640464


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3-Phosphoinositide-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eukaryotic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Janus Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoprotein Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C-epsilon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ivaska", 
        "givenName": "Johanna", 
        "id": "sg:person.01024033645.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024033645.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Complutense University of Madrid", 
          "id": "https://www.grid.ac/institutes/grid.4795.f", 
          "name": [
            "Instituto de Bioqu\u00edmica CSIC-UCM, Facultad de Farmacia, 28040 Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosca", 
        "givenName": "Lisardo", 
        "id": "sg:person.0602077255.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077255.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Peter J.", 
        "id": "sg:person.01111564441.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.274.49.34758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000238325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m101898200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001125676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m000421200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005994110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.18.5600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006020100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90115-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.4.496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021075956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.5.1352-1359.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021177705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023260839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80186-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024419719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00149.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032785037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200605200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033617526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.2.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035213793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81801-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036607290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.135.6.1633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041965823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122236099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044385592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.9.1231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046578968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.9.1231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046578968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(98)80144-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046580437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m009421200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046581402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205156200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048238919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)02500-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048897461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5367.1258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049216469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi010719z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055193855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi010719z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055193855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3520425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3520425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056720140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3520425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056720140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5314.952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5385.2042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562579"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-04", 
    "datePublishedReg": "2003-04-01", 
    "description": "The critical dependence of receptor-triggered signals on integrin-mediated cell-substrate interactions represents a fundamental biological paradigm in health and disease. However, the molecular connections of these permissive inputs, which operate through integrin-matrix interactions, has remained largely obscure. Here we show that the serine-threonine kinase protein kinase C epsilon (PKCepsilon) functions as a signal integrator between cytokine and integrin signalling pathways. Integrins are shown to control PKCepsilon phosphorylation acutely by determining complex formation with protein phosphatase 2A (PP2A) and the upstream kinase PDK1 (phosphoinositide-dependent kinase 1). The PP2A-induced loss of PKCepsilon function results in attenuated interferon gamma (INF-gamma)-induced phosphorylation of STAT1 (signal transducer and activator of transcription 1) downstream of Janus kinase 1/2 (JAK1/2). PKCepsilon function and the IFN-gamma response can be recovered by inhibition of PP2A if PDK1 is associated with PKCepsilon in this complex. More directly, a PP2A-resistant mutant of PKCepsilon is sufficient for restoration of the IFN-gamma response in suspension culture. Thus, PKCepsilon functions as a central point of integration through which integrin engagement exerts a permissive input on IFN-gamma signalling.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb957", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3747913", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "PKC\u03b5 is a permissive link in integrin-dependent IFN-\u03b3 signalling that facilitates JAK phosphorylation of STAT1", 
    "pagination": "363-369", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03fc5bff1d0a38107bec4017f6a267a5abd1d7d604f363c7c0f54938c6b5fd92"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12640464"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb957"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000836815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb957", 
      "https://app.dimensions.ai/details/publication/pub.1000836815"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29186_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ncb957"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb957'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb957'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb957'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb957'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      81 URIs      47 LITERALS      35 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb957 schema:about N0df3ec8faea448259686b12ccba58882
2 N0e62f8895c124816815ba4c1fc035e40
3 N15096afea6a14c4c80b9336050c45c1c
4 N1c9870730a9f4348a9dcda35e2defa11
5 N233924186c8d44669bbc516f5a3df304
6 N27cf058b6da84d189b2ec8616b808c77
7 N2bff7e01dbfe4b0fb7ba9ad8b0503c2e
8 N3b8e8adecc634783a1d797e904a04a39
9 N4a3b78059e9a45448b8b939373185225
10 N4e09c2272a1f41b0a012db97e7873609
11 N5349ce71ad63485681e9f4bbb1cc5e1c
12 N53b2470014d647448ff933d77a7b26f5
13 N6217919647044b819d45f7c3064591f9
14 N66aec453ac694ec4b09d5b879c108427
15 N75f18c0aed9e483c8ba92facf9c1b462
16 N8b6fd0d42bf44c959f36d9b1e194440d
17 N8fc8a8a0608d485d9d22804a02272a75
18 N9cc5d31bbf344139ab6039216f943eee
19 Na237eac375394585b112e17a79608ff0
20 Nad5aa2db9bd54518a14692e8a9911804
21 Nc976de08e01743d798bd452d68a32a1b
22 Nd9c2312c9cfb44378d4d8382762635ee
23 Ne0e56dcf3fad419db72ab068953d65c4
24 Nee9d196116e346f9a8953c18245470c9
25 Nf12ef0145b8b42c0a008b625c49fda9e
26 Nfa348217af9347dfafcebdd27d6ddb72
27 anzsrc-for:06
28 anzsrc-for:0601
29 schema:author N5aa3a916e16c42bbb3a2e8c0a46f867f
30 schema:citation https://doi.org/10.1016/0092-8674(92)90115-s
31 https://doi.org/10.1016/s0014-5793(02)02500-0
32 https://doi.org/10.1016/s0092-8674(00)81801-2
33 https://doi.org/10.1016/s0955-0674(98)80144-0
34 https://doi.org/10.1016/s0960-9822(99)80186-9
35 https://doi.org/10.1021/bi010719z
36 https://doi.org/10.1042/0264-6021:3520425
37 https://doi.org/10.1042/bj3520425
38 https://doi.org/10.1046/j.1432-1327.1999.00149.x
39 https://doi.org/10.1073/pnas.122236099
40 https://doi.org/10.1074/jbc.274.2.687
41 https://doi.org/10.1074/jbc.274.49.34758
42 https://doi.org/10.1074/jbc.m000421200
43 https://doi.org/10.1074/jbc.m009421200
44 https://doi.org/10.1074/jbc.m101898200
45 https://doi.org/10.1074/jbc.m200605200
46 https://doi.org/10.1074/jbc.m205156200
47 https://doi.org/10.1083/jcb.135.6.1633
48 https://doi.org/10.1084/jem.194.9.1231
49 https://doi.org/10.1093/emboj/16.18.5600
50 https://doi.org/10.1093/emboj/19.4.496
51 https://doi.org/10.1093/emboj/cdf371
52 https://doi.org/10.1126/science.276.5314.952
53 https://doi.org/10.1126/science.280.5367.1258
54 https://doi.org/10.1126/science.281.5385.2042
55 https://doi.org/10.1128/mcb.22.5.1352-1359.2002
56 schema:datePublished 2003-04
57 schema:datePublishedReg 2003-04-01
58 schema:description The critical dependence of receptor-triggered signals on integrin-mediated cell-substrate interactions represents a fundamental biological paradigm in health and disease. However, the molecular connections of these permissive inputs, which operate through integrin-matrix interactions, has remained largely obscure. Here we show that the serine-threonine kinase protein kinase C epsilon (PKCepsilon) functions as a signal integrator between cytokine and integrin signalling pathways. Integrins are shown to control PKCepsilon phosphorylation acutely by determining complex formation with protein phosphatase 2A (PP2A) and the upstream kinase PDK1 (phosphoinositide-dependent kinase 1). The PP2A-induced loss of PKCepsilon function results in attenuated interferon gamma (INF-gamma)-induced phosphorylation of STAT1 (signal transducer and activator of transcription 1) downstream of Janus kinase 1/2 (JAK1/2). PKCepsilon function and the IFN-gamma response can be recovered by inhibition of PP2A if PDK1 is associated with PKCepsilon in this complex. More directly, a PP2A-resistant mutant of PKCepsilon is sufficient for restoration of the IFN-gamma response in suspension culture. Thus, PKCepsilon functions as a central point of integration through which integrin engagement exerts a permissive input on IFN-gamma signalling.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf N1368526d11ac4f9f8b49275f3e567843
63 N622a03f61b694f08b79c1d39de9864a8
64 sg:journal.1021344
65 schema:name PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1
66 schema:pagination 363-369
67 schema:productId N1cb07db3ebc445a686a69c0c62af21eb
68 Nd43ad01eb2b8474da12866861a864d9e
69 Nd7e69ef37d7548a9ba7b5f20b3a1a9e0
70 Ndbd64acb79bc4d3fa2641ffb559791f4
71 Ne6e636ae010d42c1b32b4f5ffd68fabe
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000836815
73 https://doi.org/10.1038/ncb957
74 schema:sdDatePublished 2019-04-11T11:51
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N2b935f25eab34583846b35a25c9aced3
77 schema:url http://www.nature.com/articles/ncb957
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0df3ec8faea448259686b12ccba58882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Phosphorylation
83 rdf:type schema:DefinedTerm
84 N0e62f8895c124816815ba4c1fc035e40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice
86 rdf:type schema:DefinedTerm
87 N1368526d11ac4f9f8b49275f3e567843 schema:issueNumber 4
88 rdf:type schema:PublicationIssue
89 N15096afea6a14c4c80b9336050c45c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name DNA-Binding Proteins
91 rdf:type schema:DefinedTerm
92 N1c9870730a9f4348a9dcda35e2defa11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Cell Adhesion
94 rdf:type schema:DefinedTerm
95 N1cb07db3ebc445a686a69c0c62af21eb schema:name pubmed_id
96 schema:value 12640464
97 rdf:type schema:PropertyValue
98 N233924186c8d44669bbc516f5a3df304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name 3-Phosphoinositide-Dependent Protein Kinases
100 rdf:type schema:DefinedTerm
101 N27cf058b6da84d189b2ec8616b808c77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Protein Kinase C-epsilon
103 rdf:type schema:DefinedTerm
104 N2b935f25eab34583846b35a25c9aced3 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N2bff7e01dbfe4b0fb7ba9ad8b0503c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Integrins
108 rdf:type schema:DefinedTerm
109 N3b8e8adecc634783a1d797e904a04a39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Protein-Tyrosine Kinases
111 rdf:type schema:DefinedTerm
112 N4a3b78059e9a45448b8b939373185225 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mutation
114 rdf:type schema:DefinedTerm
115 N4e09c2272a1f41b0a012db97e7873609 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Protein Kinase C
117 rdf:type schema:DefinedTerm
118 N5349ce71ad63485681e9f4bbb1cc5e1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Protein Phosphatase 2
120 rdf:type schema:DefinedTerm
121 N53b2470014d647448ff933d77a7b26f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cells, Cultured
123 rdf:type schema:DefinedTerm
124 N5aa3a916e16c42bbb3a2e8c0a46f867f rdf:first sg:person.01024033645.02
125 rdf:rest Ne58445084414477396b1b52a110f87ae
126 N5f27c8ced4b34a56b3f2678c656d4afb rdf:first sg:person.01111564441.81
127 rdf:rest rdf:nil
128 N6217919647044b819d45f7c3064591f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice, Knockout
130 rdf:type schema:DefinedTerm
131 N622a03f61b694f08b79c1d39de9864a8 schema:volumeNumber 5
132 rdf:type schema:PublicationVolume
133 N66aec453ac694ec4b09d5b879c108427 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Phosphoprotein Phosphatases
135 rdf:type schema:DefinedTerm
136 N75f18c0aed9e483c8ba92facf9c1b462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 N8b6fd0d42bf44c959f36d9b1e194440d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Interferon-gamma
141 rdf:type schema:DefinedTerm
142 N8fc8a8a0608d485d9d22804a02272a75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N9cc5d31bbf344139ab6039216f943eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Membrane
147 rdf:type schema:DefinedTerm
148 Na237eac375394585b112e17a79608ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Receptors, Cell Surface
150 rdf:type schema:DefinedTerm
151 Nad5aa2db9bd54518a14692e8a9911804 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Protein-Serine-Threonine Kinases
153 rdf:type schema:DefinedTerm
154 Nc976de08e01743d798bd452d68a32a1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Signal Transduction
156 rdf:type schema:DefinedTerm
157 Nd43ad01eb2b8474da12866861a864d9e schema:name doi
158 schema:value 10.1038/ncb957
159 rdf:type schema:PropertyValue
160 Nd7e69ef37d7548a9ba7b5f20b3a1a9e0 schema:name readcube_id
161 schema:value 03fc5bff1d0a38107bec4017f6a267a5abd1d7d604f363c7c0f54938c6b5fd92
162 rdf:type schema:PropertyValue
163 Nd9c2312c9cfb44378d4d8382762635ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Eukaryotic Cells
165 rdf:type schema:DefinedTerm
166 Ndbd64acb79bc4d3fa2641ffb559791f4 schema:name dimensions_id
167 schema:value pub.1000836815
168 rdf:type schema:PropertyValue
169 Ne0e56dcf3fad419db72ab068953d65c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Trans-Activators
171 rdf:type schema:DefinedTerm
172 Ne58445084414477396b1b52a110f87ae rdf:first sg:person.0602077255.00
173 rdf:rest N5f27c8ced4b34a56b3f2678c656d4afb
174 Ne6e636ae010d42c1b32b4f5ffd68fabe schema:name nlm_unique_id
175 schema:value 100890575
176 rdf:type schema:PropertyValue
177 Nee9d196116e346f9a8953c18245470c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Enzyme Inhibitors
179 rdf:type schema:DefinedTerm
180 Nf12ef0145b8b42c0a008b625c49fda9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Janus Kinase 1
182 rdf:type schema:DefinedTerm
183 Nfa348217af9347dfafcebdd27d6ddb72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name STAT1 Transcription Factor
185 rdf:type schema:DefinedTerm
186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
187 schema:name Biological Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
190 schema:name Biochemistry and Cell Biology
191 rdf:type schema:DefinedTerm
192 sg:grant.3747913 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb957
193 rdf:type schema:MonetaryGrant
194 sg:journal.1021344 schema:issn 1465-7392
195 1476-4679
196 schema:name Nature Cell Biology
197 rdf:type schema:Periodical
198 sg:person.01024033645.02 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
199 schema:familyName Ivaska
200 schema:givenName Johanna
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024033645.02
202 rdf:type schema:Person
203 sg:person.01111564441.81 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
204 schema:familyName Parker
205 schema:givenName Peter J.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81
207 rdf:type schema:Person
208 sg:person.0602077255.00 schema:affiliation https://www.grid.ac/institutes/grid.4795.f
209 schema:familyName Bosca
210 schema:givenName Lisardo
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077255.00
212 rdf:type schema:Person
213 https://doi.org/10.1016/0092-8674(92)90115-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1007440282
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0014-5793(02)02500-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048897461
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0092-8674(00)81801-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036607290
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0955-0674(98)80144-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046580437
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0960-9822(99)80186-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024419719
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1021/bi010719z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055193855
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1042/0264-6021:3520425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715152
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1042/bj3520425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056720140
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1046/j.1432-1327.1999.00149.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032785037
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.122236099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044385592
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1074/jbc.274.2.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035213793
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1074/jbc.274.49.34758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000238325
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1074/jbc.m000421200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005994110
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1074/jbc.m009421200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046581402
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.m101898200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001125676
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.m200605200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033617526
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.m205156200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048238919
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1083/jcb.135.6.1633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041965823
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1084/jem.194.9.1231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046578968
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/emboj/16.18.5600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006020100
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1093/emboj/19.4.496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021075956
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/emboj/cdf371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023260839
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.276.5314.952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556652
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1126/science.280.5367.1258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049216469
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1126/science.281.5385.2042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562579
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/mcb.22.5.1352-1359.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177705
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
266 schema:name Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.4795.f schema:alternateName Complutense University of Madrid
269 schema:name Instituto de Bioquímica CSIC-UCM, Facultad de Farmacia, 28040 Madrid, Spain
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...