Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-12

AUTHORS

Benjamin Leader, Hyunjung Lim, Mary Jo Carabatsos, Anne Harrington, Jeffrey Ecsedy, David Pellman, Richard Maas, Philip Leder

ABSTRACT

Successful reproduction in mammals requires a competent egg, which is formed during meiosis through two assymetrical cell divisions. Here, we show that a recently identified formin homology (FH) gene, formin-2 (Fmn2), is a maternal-effect gene that is expressed in oocytes and is required for progression through metaphase of meiosis I. Fmn2(-/-) oocytes cannot correctly position the metaphase spindle during meiosis I and form the first polar body. We demonstrate that Fmn2 is required for microtubule-independent chromatin positioning during metaphase I. Fertilization of Fmn2(-/-) oocytes results in polyploid embryo formation, recurrent pregnancy loss and sub-fertility in Fmn2(-/-) females. Injection of Fmn2 mRNA into Fmn2-deficient oocytes rescues the metaphase I block. Given that errors in meiotic maturation result in severe birth defects and are the most common cause of chromosomal aneuploidy and pregnancy loss in humans, studies of Fmn2 may provide a better understanding of infertility and birth defects. More... »

PAGES

921-928

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb880

DOI

http://dx.doi.org/10.1038/ncb880

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047730354

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12447394


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