Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Cédric Polesello, Isabelle Delon, Philippe Valenti, Pierre Ferrer, François Payre

ABSTRACT

Ezrin, Radixin and Moesin (ERM) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane (PM). Here we report a genetic analysis of Dmoesin, the sole member of the ERM family in Drosophila. We show that Dmoesin is required during oogenesis for anchoring microfilaments to the oocyte cortex. Alteration of the actin cytoskeleton resulting from Dmoesin mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. This study also demonstrates the requirement of Dmoesin for the specific organization of cortical microfilaments in nurse cells and, consequently, mutations in Dmoesin produce severe defects in cell shape. More... »

PAGES

782-789

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb856

DOI

http://dx.doi.org/10.1038/ncb856

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042572147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12360288


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