Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Seiji Tanaka, John F.X. Diffley

ABSTRACT

Cdt1 is essential for loading Mcm2-7 proteins into prereplicative complexes (pre-RCs) during replication licensing and has been found in organisms as diverse as fission yeast and humans. We have identified a homologue of Cdt1 in Saccharomyces cerevisiae, which is required for pre-RC assembly. We show that, like Mcm2-7p, Cdt1p accumulates in the nucleus during G1 phase and is excluded from the nucleus later in the cell cycle by cyclin dependent kinases (cdks). Cdt1p interacts with the Mcm2--7p complex, and the nuclear accumulation of these proteins during G1 is interdependent. This coregulation of Cdt1p and Mcm2-7p represents a novel level of pre-RC control. More... »

PAGES

198-207

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb757

DOI

http://dx.doi.org/10.1038/ncb757

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035848481

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11836525


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Proteins, Non-Histone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G1 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxyurea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minichromosome Maintenance Complex Component 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Seiji", 
        "id": "sg:person.0654321475.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654321475.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diffley", 
        "givenName": "John F.X.", 
        "id": "sg:person.01070163466.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070163466.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)00337-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002462108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)00355-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003508210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81209-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004885582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(00)00158-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006492153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r000018200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011109849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.4.12b.2252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013395546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.9.12.3273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014767256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4781(98)00033-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015548047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.13.3293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015933627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.4.942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016196397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016420881", 
          "https://doi.org/10.1038/35007110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016420881", 
          "https://doi.org/10.1038/35007110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.7.11.2149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016496276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1127::aid-yea300>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017398845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1127::aid-yea300>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017398845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00196-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021068477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35055000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021402428", 
          "https://doi.org/10.1038/35055000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35055000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021402428", 
          "https://doi.org/10.1038/35055000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.1.242-248.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024343539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.11.5611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025587960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026465198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026465198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.4.480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026696714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.10.1277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028084447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.19.5966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028776607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.7.2514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030974633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90299-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032809788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(19970930)13:12<1181::aid-yea169>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034345775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(19970930)13:12<1181::aid-yea169>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034345775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35082600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036007845", 
          "https://doi.org/10.1038/35082600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35082600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036007845", 
          "https://doi.org/10.1038/35082600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90427-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036192395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037380965", 
          "https://doi.org/10.1038/35007104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037380965", 
          "https://doi.org/10.1038/35007104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039277346", 
          "https://doi.org/10.1038/15649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039277346", 
          "https://doi.org/10.1038/15649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.20.11440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040751355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5471.1643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043954418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.69.1.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045424909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.5.12.3610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047737361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.9.2082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048442592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.4637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049259729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.12.11.3658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051530011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.10.12.4043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051571946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2443.1996.840284.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052130013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2443.1996.840284.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052130013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80405-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053410629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5500.2309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062572560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8122109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074669259", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078540264", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00048.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082446276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07261.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082504755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082643441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06277.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082752632"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-03", 
    "datePublishedReg": "2002-03-01", 
    "description": "Cdt1 is essential for loading Mcm2-7 proteins into prereplicative complexes (pre-RCs) during replication licensing and has been found in organisms as diverse as fission yeast and humans. We have identified a homologue of Cdt1 in Saccharomyces cerevisiae, which is required for pre-RC assembly. We show that, like Mcm2-7p, Cdt1p accumulates in the nucleus during G1 phase and is excluded from the nucleus later in the cell cycle by cyclin dependent kinases (cdks). Cdt1p interacts with the Mcm2--7p complex, and the nuclear accumulation of these proteins during G1 is interdependent. This coregulation of Cdt1p and Mcm2-7p represents a novel level of pre-RC control.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb757", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2\u20137 during G1 phase", 
    "pagination": "198-207", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "aac538b73da753e62b34954ed062bba5e398ed86d6b178dcca2ab80362b0a2a5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11836525"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb757"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035848481"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb757", 
      "https://app.dimensions.ai/details/publication/pub.1035848481"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118309_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ncb757"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb757'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb757'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb757'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb757'


 

This table displays all metadata directly associated to this object as RDF triples.

296 TRIPLES      21 PREDICATES      95 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb757 schema:about N2f2bbd49a3894f14b73b6c6d7855c4a4
2 N37e36f55f52e43ad92ac80fdce2968d7
3 N458fec4cb05b4c628e8a5f339e2ba14d
4 N593a8e1c60a245d686f317190b514dcd
5 N5cf47a19627d40d982dbd16a3dc26073
6 N6631edbe7c2f461797b41d545f69ce23
7 N67cf790ce5db44cea6ca8c4fe72a38b9
8 N6ca1a04249704fb186b07614d863a164
9 N6e3579c5dc074d1395112ef09e30f236
10 N78e896906627475fac0bb8e209563dfd
11 N84fb267e933f49408a8b0c8f6260d9c5
12 Na43ab430bbcd472c938c77a213382152
13 Nab30fc69587f40a2a8ebe2b6d064b5a5
14 Nc808c3a3da6940758f249a54f19b58b7
15 Nd3358fec7e35427cbbc16e5ed4c17b75
16 Nd6a9a2c0b2ad406ca32a8e95b3082125
17 Ne074b3892f8c4a73999b024b6d2bf91b
18 Ne12a963f5b0e47ea90af8b7d38c103e0
19 Nec23ec2b3d0e40728771914bcd933849
20 Nfa23c4fa66ea4fb4a1148ee8bebf5d09
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author N441de8a886aa4a93a84193b88f7d93f3
24 schema:citation sg:pub.10.1038/15649
25 sg:pub.10.1038/35007104
26 sg:pub.10.1038/35007110
27 sg:pub.10.1038/35055000
28 sg:pub.10.1038/35082600
29 https://app.dimensions.ai/details/publication/pub.1074669259
30 https://app.dimensions.ai/details/publication/pub.1078540264
31 https://app.dimensions.ai/details/publication/pub.1082643441
32 https://doi.org/10.1002/(sici)1097-0061(19970930)13:12<1181::aid-yea169>3.0.co;2-o
33 https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u
34 https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1127::aid-yea300>3.0.co;2-#
35 https://doi.org/10.1002/j.1460-2075.1994.tb06277.x
36 https://doi.org/10.1002/j.1460-2075.1995.tb00048.x
37 https://doi.org/10.1002/j.1460-2075.1995.tb07261.x
38 https://doi.org/10.1006/jmbi.2001.4637
39 https://doi.org/10.1016/0092-8674(93)90427-r
40 https://doi.org/10.1016/0092-8674(94)90299-2
41 https://doi.org/10.1016/s0092-8674(00)81209-x
42 https://doi.org/10.1016/s0167-4781(98)00033-5
43 https://doi.org/10.1016/s0959-437x(00)00158-1
44 https://doi.org/10.1016/s0960-9822(00)00337-7
45 https://doi.org/10.1016/s0960-9822(00)00355-9
46 https://doi.org/10.1016/s0960-9822(01)00196-8
47 https://doi.org/10.1016/s1097-2765(00)80405-0
48 https://doi.org/10.1046/j.1365-2443.1996.840284.x
49 https://doi.org/10.1073/pnas.92.7.2514
50 https://doi.org/10.1073/pnas.94.11.5611
51 https://doi.org/10.1073/pnas.96.20.11440
52 https://doi.org/10.1074/jbc.r000018200
53 https://doi.org/10.1091/mbc.10.12.4043
54 https://doi.org/10.1091/mbc.12.11.3658
55 https://doi.org/10.1091/mbc.9.12.3273
56 https://doi.org/10.1093/emboj/16.19.5966
57 https://doi.org/10.1093/emboj/19.9.2082
58 https://doi.org/10.1093/emboj/20.13.3293
59 https://doi.org/10.1093/nar/26.4.942
60 https://doi.org/10.1101/gad.11.10.1277
61 https://doi.org/10.1101/gad.12.4.480
62 https://doi.org/10.1101/gad.4.12b.2252
63 https://doi.org/10.1101/gad.7.11.2149
64 https://doi.org/10.1126/science.288.5471.1643
65 https://doi.org/10.1126/science.290.5500.2309
66 https://doi.org/10.1126/science.8122109
67 https://doi.org/10.1128/mcb.20.1.242-248.2000
68 https://doi.org/10.1128/mcb.5.12.3610
69 https://doi.org/10.1146/annurev.biochem.69.1.829
70 schema:datePublished 2002-03
71 schema:datePublishedReg 2002-03-01
72 schema:description Cdt1 is essential for loading Mcm2-7 proteins into prereplicative complexes (pre-RCs) during replication licensing and has been found in organisms as diverse as fission yeast and humans. We have identified a homologue of Cdt1 in Saccharomyces cerevisiae, which is required for pre-RC assembly. We show that, like Mcm2-7p, Cdt1p accumulates in the nucleus during G1 phase and is excluded from the nucleus later in the cell cycle by cyclin dependent kinases (cdks). Cdt1p interacts with the Mcm2--7p complex, and the nuclear accumulation of these proteins during G1 is interdependent. This coregulation of Cdt1p and Mcm2-7p represents a novel level of pre-RC control.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree false
76 schema:isPartOf N7df31af6603747f885f40b15debdc6c3
77 Nc8a24c8ae7e84badbf72f1de2c996090
78 sg:journal.1021344
79 schema:name Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase
80 schema:pagination 198-207
81 schema:productId N01b3618a47e14eae90c3ad5a6d0c6d60
82 N48172580f5914069a1d73d9364bacc77
83 N77cfbf8b2af2438993771f9af6d6aae2
84 N9caaedaa25814cce8002f16f745ec0ae
85 Na0a7ac475f904ed68a6f3ad6656d6cf4
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035848481
87 https://doi.org/10.1038/ncb757
88 schema:sdDatePublished 2019-04-11T12:03
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N87436a97bf3e4dbc8a311e8796072905
91 schema:url http://www.nature.com/articles/ncb757
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N01b3618a47e14eae90c3ad5a6d0c6d60 schema:name nlm_unique_id
96 schema:value 100890575
97 rdf:type schema:PropertyValue
98 N2f2bbd49a3894f14b73b6c6d7855c4a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Amino Acid Sequence
100 rdf:type schema:DefinedTerm
101 N37e36f55f52e43ad92ac80fdce2968d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Hydroxyurea
103 rdf:type schema:DefinedTerm
104 N441de8a886aa4a93a84193b88f7d93f3 rdf:first sg:person.0654321475.75
105 rdf:rest N9fba5878e90c401dbeff82f525aa0e88
106 N458fec4cb05b4c628e8a5f339e2ba14d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Chromosomal Proteins, Non-Histone
108 rdf:type schema:DefinedTerm
109 N48172580f5914069a1d73d9364bacc77 schema:name doi
110 schema:value 10.1038/ncb757
111 rdf:type schema:PropertyValue
112 N593a8e1c60a245d686f317190b514dcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Saccharomyces cerevisiae
114 rdf:type schema:DefinedTerm
115 N5cf47a19627d40d982dbd16a3dc26073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name DNA-Binding Proteins
117 rdf:type schema:DefinedTerm
118 N6631edbe7c2f461797b41d545f69ce23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name G1 Phase
120 rdf:type schema:DefinedTerm
121 N67cf790ce5db44cea6ca8c4fe72a38b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Recombinant Fusion Proteins
123 rdf:type schema:DefinedTerm
124 N6ca1a04249704fb186b07614d863a164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Minichromosome Maintenance Complex Component 7
126 rdf:type schema:DefinedTerm
127 N6e3579c5dc074d1395112ef09e30f236 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Macromolecular Substances
129 rdf:type schema:DefinedTerm
130 N77cfbf8b2af2438993771f9af6d6aae2 schema:name dimensions_id
131 schema:value pub.1035848481
132 rdf:type schema:PropertyValue
133 N78e896906627475fac0bb8e209563dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cyclin-Dependent Kinases
135 rdf:type schema:DefinedTerm
136 N7df31af6603747f885f40b15debdc6c3 schema:volumeNumber 4
137 rdf:type schema:PublicationVolume
138 N84fb267e933f49408a8b0c8f6260d9c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Nucleus
140 rdf:type schema:DefinedTerm
141 N87436a97bf3e4dbc8a311e8796072905 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N9caaedaa25814cce8002f16f745ec0ae schema:name readcube_id
144 schema:value aac538b73da753e62b34954ed062bba5e398ed86d6b178dcca2ab80362b0a2a5
145 rdf:type schema:PropertyValue
146 N9fba5878e90c401dbeff82f525aa0e88 rdf:first sg:person.01070163466.42
147 rdf:rest rdf:nil
148 Na0a7ac475f904ed68a6f3ad6656d6cf4 schema:name pubmed_id
149 schema:value 11836525
150 rdf:type schema:PropertyValue
151 Na43ab430bbcd472c938c77a213382152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Fungal Proteins
153 rdf:type schema:DefinedTerm
154 Nab30fc69587f40a2a8ebe2b6d064b5a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nc808c3a3da6940758f249a54f19b58b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Nuclear Proteins
159 rdf:type schema:DefinedTerm
160 Nc8a24c8ae7e84badbf72f1de2c996090 schema:issueNumber 3
161 rdf:type schema:PublicationIssue
162 Nd3358fec7e35427cbbc16e5ed4c17b75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name DNA Replication
164 rdf:type schema:DefinedTerm
165 Nd6a9a2c0b2ad406ca32a8e95b3082125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Saccharomyces cerevisiae Proteins
167 rdf:type schema:DefinedTerm
168 Ne074b3892f8c4a73999b024b6d2bf91b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Sequence Homology, Amino Acid
170 rdf:type schema:DefinedTerm
171 Ne12a963f5b0e47ea90af8b7d38c103e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Animals
173 rdf:type schema:DefinedTerm
174 Nec23ec2b3d0e40728771914bcd933849 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cell Cycle Proteins
176 rdf:type schema:DefinedTerm
177 Nfa23c4fa66ea4fb4a1148ee8bebf5d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Molecular Sequence Data
179 rdf:type schema:DefinedTerm
180 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
181 schema:name Biological Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
184 schema:name Biochemistry and Cell Biology
185 rdf:type schema:DefinedTerm
186 sg:journal.1021344 schema:issn 1465-7392
187 1476-4679
188 schema:name Nature Cell Biology
189 rdf:type schema:Periodical
190 sg:person.01070163466.42 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
191 schema:familyName Diffley
192 schema:givenName John F.X.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070163466.42
194 rdf:type schema:Person
195 sg:person.0654321475.75 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
196 schema:familyName Tanaka
197 schema:givenName Seiji
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654321475.75
199 rdf:type schema:Person
200 sg:pub.10.1038/15649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039277346
201 https://doi.org/10.1038/15649
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/35007104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037380965
204 https://doi.org/10.1038/35007104
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/35007110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016420881
207 https://doi.org/10.1038/35007110
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/35055000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021402428
210 https://doi.org/10.1038/35055000
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/35082600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036007845
213 https://doi.org/10.1038/35082600
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1074669259 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1078540264 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1082643441 schema:CreativeWork
218 https://doi.org/10.1002/(sici)1097-0061(19970930)13:12<1181::aid-yea169>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1034345775
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1026465198
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1127::aid-yea300>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1017398845
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/j.1460-2075.1994.tb06277.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082752632
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/j.1460-2075.1995.tb00048.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082446276
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/j.1460-2075.1995.tb07261.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082504755
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1006/jmbi.2001.4637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049259729
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0092-8674(93)90427-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1036192395
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0092-8674(94)90299-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032809788
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0092-8674(00)81209-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004885582
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0167-4781(98)00033-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015548047
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0959-437x(00)00158-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006492153
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0960-9822(00)00337-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002462108
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0960-9822(00)00355-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003508210
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0960-9822(01)00196-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021068477
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s1097-2765(00)80405-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053410629
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1046/j.1365-2443.1996.840284.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052130013
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1073/pnas.92.7.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030974633
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.94.11.5611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025587960
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.96.20.11440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040751355
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.r000018200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011109849
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1091/mbc.10.12.4043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051571946
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1091/mbc.12.11.3658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051530011
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1091/mbc.9.12.3273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014767256
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/emboj/16.19.5966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028776607
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1093/emboj/19.9.2082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048442592
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/emboj/20.13.3293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015933627
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/nar/26.4.942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016196397
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1101/gad.11.10.1277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028084447
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1101/gad.12.4.480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026696714
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1101/gad.4.12b.2252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395546
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1101/gad.7.11.2149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016496276
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1126/science.288.5471.1643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043954418
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.290.5500.2309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572560
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.8122109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652845
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1128/mcb.20.1.242-248.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024343539
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1128/mcb.5.12.3610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047737361
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1146/annurev.biochem.69.1.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045424909
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.11485.39 schema:alternateName Cancer Research UK
295 schema:name Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, UK
296 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...