Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Seiji Tanaka, John F.X. Diffley

ABSTRACT

Cdt1 is essential for loading Mcm2-7 proteins into prereplicative complexes (pre-RCs) during replication licensing and has been found in organisms as diverse as fission yeast and humans. We have identified a homologue of Cdt1 in Saccharomyces cerevisiae, which is required for pre-RC assembly. We show that, like Mcm2-7p, Cdt1p accumulates in the nucleus during G1 phase and is excluded from the nucleus later in the cell cycle by cyclin dependent kinases (cdks). Cdt1p interacts with the Mcm2--7p complex, and the nuclear accumulation of these proteins during G1 is interdependent. This coregulation of Cdt1p and Mcm2-7p represents a novel level of pre-RC control. More... »

PAGES

198-207

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb757

DOI

http://dx.doi.org/10.1038/ncb757

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035848481

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11836525


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N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb757'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb757'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb757'


 

This table displays all metadata directly associated to this object as RDF triples.

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