Ontology type: schema:ScholarlyArticle
2002-02
AUTHORSMaximilian Fürthauer, Wei Lin, Siew-Lan Ang, Bernard Thisse, Christine Thisse
ABSTRACTFibroblast growth factors (FGFs) are pleiotrophic growth factors that control cell proliferation, migration, differentiation and embryonic patterning. During early zebrafish embryonic development, FGFs regulate dorsoventral patterning by controlling ventral bone morphogenetic protein (BMP) expression. FGFs function by binding and activating high-affinity tyrosine kinase receptors. FGF activity is negatively regulated by members of the Sprouty family, which antagonize Ras signalling induced by receptor tyrosine kinases. On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes). Sef encodes a conserved putative transmembrane protein that shares sequence similarities with the intracellular domain of the interleukin 17 receptor. Here we show that in zebrafish, Sef functions as a feedback-induced antagonist of Ras/Raf/MEK/MAPK-mediated FGF signalling. More... »
PAGES170-174
http://scigraph.springernature.com/pub.10.1038/ncb750
DOIhttp://dx.doi.org/10.1038/ncb750
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1033117382
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11802165
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Embryo, Nonmammalian",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fibroblast Growth Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Developmental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "In Situ Hybridization",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "MAP Kinase Signaling System",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-raf",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Alignment",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Zebrafish",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Zebrafish Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ras Proteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch cedex, CU de Strasbourg, France."
],
"type": "Organization"
},
"familyName": "F\u00fcrthauer",
"givenName": "Maximilian",
"id": "sg:person.016417065547.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016417065547.14"
],
"type": "Person"
},
{
"familyName": "Lin",
"givenName": "Wei",
"id": "sg:person.01150537057.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150537057.41"
],
"type": "Person"
},
{
"familyName": "Ang",
"givenName": "Siew-Lan",
"id": "sg:person.01040151557.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040151557.13"
],
"type": "Person"
},
{
"familyName": "Thisse",
"givenName": "Bernard",
"id": "sg:person.01026473264.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026473264.42"
],
"type": "Person"
},
{
"familyName": "Thisse",
"givenName": "Christine",
"id": "sg:person.01074114420.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074114420.95"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1093/nar/27.1.215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000828658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3510289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001160045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj3510289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001160045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1998.9280",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001382404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1074-7613(95)90070-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002009097"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/79951",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007182261",
"https://doi.org/10.1038/79951"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/79951",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007182261",
"https://doi.org/10.1038/79951"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/376058a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007829605",
"https://doi.org/10.1038/376058a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(00)00431-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008993460"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(95)00017-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012264720"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0076-6879(93)25026-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017070581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)80576-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017102233"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)80919-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017981095"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/357252a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023099265",
"https://doi.org/10.1038/357252a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1359-6101(96)00039-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025433593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(01)00143-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029931335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(01)00143-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029931335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0925-4773(01)00456-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030580059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0925-4773(01)00456-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030580059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(99)80094-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035316167"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.122.3.645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039357768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/dbio.1994.1212",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042776613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/0264-6021:3510289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056715041"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1829549",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062508809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.276.5314.955",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062556653"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.277.5329.1103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062557758"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074525939",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074673625",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074860840",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083036725",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083160575",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083270762",
"type": "CreativeWork"
}
],
"datePublished": "2002-02",
"datePublishedReg": "2002-02-01",
"description": "Fibroblast growth factors (FGFs) are pleiotrophic growth factors that control cell proliferation, migration, differentiation and embryonic patterning. During early zebrafish embryonic development, FGFs regulate dorsoventral patterning by controlling ventral bone morphogenetic protein (BMP) expression. FGFs function by binding and activating high-affinity tyrosine kinase receptors. FGF activity is negatively regulated by members of the Sprouty family, which antagonize Ras signalling induced by receptor tyrosine kinases. On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes). Sef encodes a conserved putative transmembrane protein that shares sequence similarities with the intracellular domain of the interleukin 17 receptor. Here we show that in zebrafish, Sef functions as a feedback-induced antagonist of Ras/Raf/MEK/MAPK-mediated FGF signalling.",
"genre": "research_article",
"id": "sg:pub.10.1038/ncb750",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2778670",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2564599",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1021344",
"issn": [
"1465-7392",
"1476-4679"
],
"name": "Nature Cell Biology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "4"
}
],
"name": "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling",
"pagination": "170-174",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9dc40c3452931dc0bf1e599ebe24e9a4f3af1f2aebebfa8898418e42fc8266b2"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11802165"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100890575"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ncb750"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1033117382"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ncb750",
"https://app.dimensions.ai/details/publication/pub.1033117382"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:05",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118324_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/ncb/journal/v4/n2/full/ncb750.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb750'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb750'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb750'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb750'
This table displays all metadata directly associated to this object as RDF triples.
237 TRIPLES
21 PREDICATES
72 URIs
36 LITERALS
24 BLANK NODES