Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Masafumi Muratani, Daniel Gerlich, Susan M. Janicki, Matthias Gebhard, Roland Eils, David L. Spector

ABSTRACT

Promyelocytic leukaemia (PML) nuclear bodies are present in most mammalian cell nuclei. PML bodies are disrupted by PML retinoic acid receptor alpha (RAR alpha) oncoproteins in acute promyelocytic leukaemia. These bodies contain numerous proteins, including Sp100, SUMO-1, HAUSP(USP7), CBP and BLM, and they have been implicated in aspects of transcriptional regulation or as nuclear storage depots. Here, we show that three classes of PML nuclear bodies can be distinguished, on the basis of their dynamic properties in living cells. One class of PML bodies is particularly noteworthy in that it moves by a metabolic-energy-dependent mechanism. This represents the first example of metabolic-energy-dependent transport of a nuclear body within the mammalian cell nucleus. More... »

PAGES

106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb740

DOI

http://dx.doi.org/10.1038/ncb740

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017972022

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11753375


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb740'

RDF/XML is a standard XML format for linked data.

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