Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

Allison L. Boyd, Jennifer C. Reid, Kyle R. Salci, Lili Aslostovar, Yannick D. Benoit, Zoya Shapovalova, Mio Nakanishi, Deanna P. Porras, Mohammed Almakadi, Clinton J. V. Campbell, Michael F. Jackson, Catherine A. Ross, Ronan Foley, Brian Leber, David S. Allan, Mitchell Sabloff, Anargyros Xenocostas, Tony J. Collins, Mickie Bhatia

ABSTRACT

Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of bone marrow (BM) by accumulating leukaemic cells does not fully account for this haematopoietic failure. Here, analyses from AML patients were applied to both in vitro co-culture platforms and in vivo xenograft modelling, revealing that human AML disease specifically disrupts the adipocytic niche in BM. Leukaemic suppression of BM adipocytes led to imbalanced regulation of endogenous haematopoietic stem and progenitor cells, resulting in impaired myelo-erythroid maturation. In vivo administration of PPARγ agonists induced BM adipogenesis, which rescued healthy haematopoietic maturation while repressing leukaemic growth. Our study identifies a previously unappreciated axis between BM adipogenesis and normal myelo-erythroid maturation that is therapeutically accessible to improve symptoms of BM failure in AML via non-cell autonomous targeting of the niche. More... »

PAGES

1336-1347

References to SciGraph publications

  • 2013-12. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells in NATURE CHEMICAL BIOLOGY
  • 1997-07. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell in NATURE MEDICINE
  • 2013-09. Regulation of adipocyte differentiation and gene expression-crosstalk between TGFβ and wnt signaling pathways in MOLECULAR BIOLOGY REPORTS
  • 2016-09. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway in SCIENTIFIC REPORTS
  • 2014-01. The bone marrow niche for haematopoietic stem cells in NATURE
  • 2010-08. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche in NATURE
  • 2017-08. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF in NATURE CELL BIOLOGY
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • 2013-03. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches in NATURE
  • 2016-07. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? in CELL DEATH & DIFFERENTIATION
  • 2008-06-05. Dynamics of fat cell turnover in humans in NATURE
  • 2003-10. Osteoblastic cells regulate the haematopoietic stem cell niche in NATURE
  • 2003-10. Identification of the haematopoietic stem cell niche and control of the niche size in NATURE
  • 2016-12. Acute Myeloid Leukemia: How Do We Measure Success? in CURRENT HEMATOLOGIC MALIGNANCY REPORTS
  • 2014-02. Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts in NATURE
  • 2013-09. Interactions Between B Lymphocytes and the Osteoblast Lineage in Bone Marrow in CALCIFIED TISSUE INTERNATIONAL
  • 2009-01. Detection of functional haematopoietic stem cell niche using real-time imaging in NATURE
  • 2009-07. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment in NATURE
  • 2015-12. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb3625

    DOI

    http://dx.doi.org/10.1038/ncb3625

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092237073

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29035359


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coculture Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Erythropoiesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred NOD", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "PPAR gamma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boyd", 
            "givenName": "Allison L.", 
            "id": "sg:person.0613106413.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613106413.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reid", 
            "givenName": "Jennifer C.", 
            "id": "sg:person.010035672317.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010035672317.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salci", 
            "givenName": "Kyle R.", 
            "id": "sg:person.0732602775.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732602775.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aslostovar", 
            "givenName": "Lili", 
            "id": "sg:person.01020324730.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020324730.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benoit", 
            "givenName": "Yannick D.", 
            "id": "sg:person.01045256371.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045256371.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shapovalova", 
            "givenName": "Zoya", 
            "id": "sg:person.01007176771.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007176771.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakanishi", 
            "givenName": "Mio", 
            "id": "sg:person.011526062323.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011526062323.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Porras", 
            "givenName": "Deanna P.", 
            "id": "sg:person.01175600300.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175600300.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Almakadi", 
            "givenName": "Mohammed", 
            "id": "sg:person.01275006705.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275006705.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campbell", 
            "givenName": "Clinton J. V.", 
            "id": "sg:person.01214636131.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214636131.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manitoba", 
              "id": "https://www.grid.ac/institutes/grid.21613.37", 
              "name": [
                "Central Animal Core Imaging and Transgenic Facilities, Central Animal Care Services, Rady Faculty of Health Sciences, University of Manitoba, 710 William Avenue, SR426 Winnipeg, Manitoba R3E 0Z3, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jackson", 
            "givenName": "Michael F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ross", 
            "givenName": "Catherine A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Foley", 
            "givenName": "Ronan", 
            "id": "sg:person.01223240534.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223240534.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leber", 
            "givenName": "Brian", 
            "id": "sg:person.01014244717.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014244717.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ottawa Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Medicine, Division of Hematology, Ottawa Hospital Research Institute, Ottawa, Ontario\u00a0K1H\u00a08L6, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allan", 
            "givenName": "David S.", 
            "id": "sg:person.010471603052.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010471603052.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ottawa Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Medicine, Division of Hematology, Ottawa Hospital Research Institute, Ottawa, Ontario\u00a0K1H\u00a08L6, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sabloff", 
            "givenName": "Mitchell", 
            "id": "sg:person.01034312621.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034312621.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western University", 
              "id": "https://www.grid.ac/institutes/grid.39381.30", 
              "name": [
                "Department of Medicine, Division of Hematology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xenocostas", 
            "givenName": "Anargyros", 
            "id": "sg:person.01241456532.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241456532.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Collins", 
            "givenName": "Tony J.", 
            "id": "sg:person.0634337371.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634337371.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhatia", 
            "givenName": "Mickie", 
            "id": "sg:person.01160110173.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160110173.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1152/ajpgi.00265.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000958132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0000000000000133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001965004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0000000000000133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001965004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509222", 
              "https://doi.org/10.1038/nature02040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509222", 
              "https://doi.org/10.1038/nature02040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003648329", 
              "https://doi.org/10.1038/ncomms8808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2184.2009.00661.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003796794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2184.2009.00661.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003796794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db11-1293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003960919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1301891110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004594215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0000000000000055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005096725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/moh.0000000000000055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005096725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.02.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006485513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2443.2009.01281.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007907604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011517403", 
              "https://doi.org/10.1038/nature08099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011517403", 
              "https://doi.org/10.1038/nature08099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20140131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011980281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcla.20001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013939475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014359323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a011668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014404832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0046483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015164984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016677250", 
              "https://doi.org/10.1038/nature12883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2016.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018825035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018866560", 
              "https://doi.org/10.1038/nature07639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-07-517219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020671091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020874829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-06-2325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022303201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0797-730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022333282", 
              "https://doi.org/10.1038/nm0797-730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022343554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2016.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022752029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022774714", 
              "https://doi.org/10.1038/nature09262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022774714", 
              "https://doi.org/10.1038/nature09262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-1962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023177633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-013-2623-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023959755", 
              "https://doi.org/10.1007/s11033-013-2623-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.2208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/toxsci/kfr140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026304424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367645a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028822583", 
              "https://doi.org/10.1038/367645a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00223-013-9753-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029084340", 
              "https://doi.org/10.1007/s00223-013-9753-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0090639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029760820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033616640", 
              "https://doi.org/10.1038/nature02041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033616640", 
              "https://doi.org/10.1038/nature02041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2015.168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033921991", 
              "https://doi.org/10.1038/cdd.2015.168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2016.00085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033926636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2014.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034784444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-04-348151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034822951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/ijms.4476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034885001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci64745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037650489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038795491", 
              "https://doi.org/10.1038/nature11885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2013.05.287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040593693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-07-235358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042177075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-11-570218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042684547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.22793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043286678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2016.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044003649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11899-016-0346-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045125078", 
              "https://doi.org/10.1007/s11899-016-0346-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11899-016-0346-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045125078", 
              "https://doi.org/10.1007/s11899-016-0346-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045199334", 
              "https://doi.org/10.1038/nature12984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045763666", 
              "https://doi.org/10.1038/nchembio.1367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(06)69780-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046790794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep23479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047157417", 
              "https://doi.org/10.1038/srep23479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047374084", 
              "https://doi.org/10.1038/nature06902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.24954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049703137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.06.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049754164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2016.03.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050438049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.22289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053551159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.22289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053551159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2016-08-734798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.48.7.1415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070744225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076951317", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082600667", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2016-11-696070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083534677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2017.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084109665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747965", 
              "https://doi.org/10.1038/ncb3570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747965", 
              "https://doi.org/10.1038/ncb3570"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-11", 
        "datePublishedReg": "2017-11-01", 
        "description": "Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of bone marrow (BM) by accumulating leukaemic cells does not fully account for this haematopoietic failure. Here, analyses from AML patients were applied to both in vitro co-culture platforms and in vivo xenograft modelling, revealing that human AML disease specifically disrupts the adipocytic niche in BM. Leukaemic suppression of BM adipocytes led to imbalanced regulation of endogenous haematopoietic stem and progenitor cells, resulting in impaired myelo-erythroid maturation. In vivo administration of PPAR\u03b3 agonists induced BM adipogenesis, which rescued healthy haematopoietic maturation while repressing leukaemic growth. Our study identifies a previously unappreciated axis between BM adipogenesis and normal myelo-erythroid maturation that is therapeutically accessible to improve symptoms of BM failure in AML via non-cell autonomous targeting of the niche.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ncb3625", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1021344", 
            "issn": [
              "1465-7392", 
              "1476-4679"
            ], 
            "name": "Nature Cell Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche", 
        "pagination": "1336-1347", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "da736358506e915d8ffe7678d7471c398fe2db70bf603af83181bf6e8f6bfb3c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29035359"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100890575"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncb3625"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092237073"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncb3625", 
          "https://app.dimensions.ai/details/publication/pub.1092237073"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29215_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ncb3625"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb3625'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb3625'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb3625'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb3625'


     

    This table displays all metadata directly associated to this object as RDF triples.

    493 TRIPLES      21 PREDICATES      113 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncb3625 schema:about N024b449f0cb942ae9c723c7629c7a12a
    2 N0d5dca5286924f688c88ddd5b5b5ce4e
    3 N0e3d99a6a732432384a6af89122da0e2
    4 N1a77c67e5db64fe48e6e949e45f1ec18
    5 N2ce02d951c114890a0a3fea18a6613d4
    6 N3a5ee83ffad8442ab670d6d3c8691dee
    7 N4c5af0b34f0246d79fb2ab0b4969d37e
    8 N4d8d6bb1e92e4e59bb929cf3d2d885da
    9 N5b1b5d4212d44083849a15390182c349
    10 N72be8ed605a745c29027b17609220c5e
    11 N7763d64ba2e84aff85f30a3cb29d32cc
    12 N7f61282807b94fa28581939f6569ba3e
    13 N84384d653d7f48838364a659a3191035
    14 N934117e2686640db8155211a45ad91be
    15 N9992e411c94e441e93580fbe390910b4
    16 Na41dc7c503684b0cae70676aeef64153
    17 Nc23004fe7330447cadba42d0cecf4be4
    18 Nca82bde1586944208926deb402387469
    19 Ne715e92d95564980a7f1f818cb647386
    20 Nffa2944bc63b4fd9932e93e1b39d087f
    21 anzsrc-for:11
    22 anzsrc-for:1102
    23 schema:author Na7d57868704542d19d39be5b6c15dd17
    24 schema:citation sg:pub.10.1007/s00223-013-9753-3
    25 sg:pub.10.1007/s11033-013-2623-2
    26 sg:pub.10.1007/s11899-016-0346-x
    27 sg:pub.10.1038/367645a0
    28 sg:pub.10.1038/cdd.2015.168
    29 sg:pub.10.1038/nature02040
    30 sg:pub.10.1038/nature02041
    31 sg:pub.10.1038/nature06902
    32 sg:pub.10.1038/nature07639
    33 sg:pub.10.1038/nature08099
    34 sg:pub.10.1038/nature09262
    35 sg:pub.10.1038/nature11885
    36 sg:pub.10.1038/nature12883
    37 sg:pub.10.1038/nature12984
    38 sg:pub.10.1038/ncb3570
    39 sg:pub.10.1038/nchembio.1367
    40 sg:pub.10.1038/ncomms8808
    41 sg:pub.10.1038/nm0797-730
    42 sg:pub.10.1038/srep23479
    43 https://app.dimensions.ai/details/publication/pub.1076951317
    44 https://app.dimensions.ai/details/publication/pub.1082600667
    45 https://doi.org/10.1002/jcb.22289
    46 https://doi.org/10.1002/jcb.22793
    47 https://doi.org/10.1002/jcla.20001
    48 https://doi.org/10.1002/jcp.24954
    49 https://doi.org/10.1002/stem.2208
    50 https://doi.org/10.1016/j.devcel.2014.03.013
    51 https://doi.org/10.1016/j.exphem.2013.05.287
    52 https://doi.org/10.1016/j.stem.2013.06.009
    53 https://doi.org/10.1016/j.stem.2013.06.015
    54 https://doi.org/10.1016/j.stem.2014.02.014
    55 https://doi.org/10.1016/j.stem.2014.06.020
    56 https://doi.org/10.1016/j.stem.2016.06.001
    57 https://doi.org/10.1016/j.stem.2017.02.009
    58 https://doi.org/10.1016/j.stemcr.2016.06.009
    59 https://doi.org/10.1016/j.tem.2016.03.016
    60 https://doi.org/10.1016/j.yexcr.2016.03.007
    61 https://doi.org/10.1016/s0140-6736(06)69780-8
    62 https://doi.org/10.1073/pnas.0506580102
    63 https://doi.org/10.1073/pnas.1301891110
    64 https://doi.org/10.1084/jem.20140131
    65 https://doi.org/10.1093/toxsci/kfr140
    66 https://doi.org/10.1097/moh.0000000000000055
    67 https://doi.org/10.1097/moh.0000000000000133
    68 https://doi.org/10.1101/cshperspect.a011668
    69 https://doi.org/10.1111/j.1365-2184.2009.00661.x
    70 https://doi.org/10.1111/j.1365-2443.2009.01281.x
    71 https://doi.org/10.1152/ajpgi.00265.2009
    72 https://doi.org/10.1158/0008-5472.can-09-1962
    73 https://doi.org/10.1172/jci64745
    74 https://doi.org/10.1182/blood-2005-06-2325
    75 https://doi.org/10.1182/blood-2009-07-235358
    76 https://doi.org/10.1182/blood-2011-04-348151
    77 https://doi.org/10.1182/blood-2013-07-517219
    78 https://doi.org/10.1182/blood-2014-11-570218
    79 https://doi.org/10.1182/blood-2016-08-734798
    80 https://doi.org/10.1182/blood-2016-11-696070
    81 https://doi.org/10.1371/journal.pone.0046483
    82 https://doi.org/10.1371/journal.pone.0090639
    83 https://doi.org/10.18632/oncotarget.7964
    84 https://doi.org/10.2337/db11-1293
    85 https://doi.org/10.2337/diabetes.48.7.1415
    86 https://doi.org/10.3389/fendo.2016.00085
    87 https://doi.org/10.7150/ijms.4476
    88 schema:datePublished 2017-11
    89 schema:datePublishedReg 2017-11-01
    90 schema:description Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of bone marrow (BM) by accumulating leukaemic cells does not fully account for this haematopoietic failure. Here, analyses from AML patients were applied to both in vitro co-culture platforms and in vivo xenograft modelling, revealing that human AML disease specifically disrupts the adipocytic niche in BM. Leukaemic suppression of BM adipocytes led to imbalanced regulation of endogenous haematopoietic stem and progenitor cells, resulting in impaired myelo-erythroid maturation. In vivo administration of PPARγ agonists induced BM adipogenesis, which rescued healthy haematopoietic maturation while repressing leukaemic growth. Our study identifies a previously unappreciated axis between BM adipogenesis and normal myelo-erythroid maturation that is therapeutically accessible to improve symptoms of BM failure in AML via non-cell autonomous targeting of the niche.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree false
    94 schema:isPartOf N127a2206f78342148b4276583112827b
    95 Nc8267d26a0864389960d9783886e67e8
    96 sg:journal.1021344
    97 schema:name Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
    98 schema:pagination 1336-1347
    99 schema:productId N848428d8578b46f98d57f3fceb4e79ef
    100 Nabb62a7402434532a6d43ba7f60e8ce3
    101 Nccbcb5e1b4e84adf93aec247d1b3e039
    102 Nd71e5e08b3dc453ab7600ce745289456
    103 Nf232b5a7ce5643d9a84a5afe66625d5c
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092237073
    105 https://doi.org/10.1038/ncb3625
    106 schema:sdDatePublished 2019-04-11T11:56
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher Na6c73024f77f479699e6fde69a73a666
    109 schema:url http://www.nature.com/articles/ncb3625
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N024b449f0cb942ae9c723c7629c7a12a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Bone Marrow Cells
    115 rdf:type schema:DefinedTerm
    116 N08be44457dc245289b1318b050cd525b rdf:first sg:person.010035672317.19
    117 rdf:rest Nc7a5e17408ea4fc7a48148810f39b62a
    118 N0d5dca5286924f688c88ddd5b5b5ce4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Hematopoietic Stem Cells
    120 rdf:type schema:DefinedTerm
    121 N0e3d99a6a732432384a6af89122da0e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Adipogenesis
    123 rdf:type schema:DefinedTerm
    124 N127a2206f78342148b4276583112827b schema:issueNumber 11
    125 rdf:type schema:PublicationIssue
    126 N16c0023e9fad48b38ea6ca0d571622b8 rdf:first sg:person.010471603052.51
    127 rdf:rest N9bb760b724474aa59ea20562ea955640
    128 N1a77c67e5db64fe48e6e949e45f1ec18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Coculture Techniques
    130 rdf:type schema:DefinedTerm
    131 N211509a62f954362a0e18fc172ae2f94 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    132 schema:familyName Ross
    133 schema:givenName Catherine A.
    134 rdf:type schema:Person
    135 N29cb67dd38e44ca1ba4ef0640c4018e0 rdf:first sg:person.01223240534.95
    136 rdf:rest N4dcd158aec5e4c29b5237532cebc4791
    137 N2b7a6493dd644fe28d8976555eac3553 rdf:first N211509a62f954362a0e18fc172ae2f94
    138 rdf:rest N29cb67dd38e44ca1ba4ef0640c4018e0
    139 N2ce02d951c114890a0a3fea18a6613d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Stem Cells
    141 rdf:type schema:DefinedTerm
    142 N3a5ee83ffad8442ab670d6d3c8691dee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name PPAR gamma
    144 rdf:type schema:DefinedTerm
    145 N445ad8a8909a4a74bb1b3d17ad2d95c5 rdf:first sg:person.01275006705.48
    146 rdf:rest Nc3917883c42248bca79a5a554c91f08c
    147 N4b7d18a2966147319d1d8de0194877a1 rdf:first Nd482571a9bb0458a9c98879ce63ce45d
    148 rdf:rest N2b7a6493dd644fe28d8976555eac3553
    149 N4c5af0b34f0246d79fb2ab0b4969d37e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Bone Marrow
    151 rdf:type schema:DefinedTerm
    152 N4d8d6bb1e92e4e59bb929cf3d2d885da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Male
    154 rdf:type schema:DefinedTerm
    155 N4dcd158aec5e4c29b5237532cebc4791 rdf:first sg:person.01014244717.82
    156 rdf:rest N16c0023e9fad48b38ea6ca0d571622b8
    157 N5b1b5d4212d44083849a15390182c349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Adult
    159 rdf:type schema:DefinedTerm
    160 N7193c01fdfda4efe83c03ef8e21d1300 rdf:first sg:person.01160110173.62
    161 rdf:rest rdf:nil
    162 N72be8ed605a745c29027b17609220c5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Mice, Inbred NOD
    164 rdf:type schema:DefinedTerm
    165 N7350c0f0313345f8b0f776cc3a832f90 rdf:first sg:person.0634337371.00
    166 rdf:rest N7193c01fdfda4efe83c03ef8e21d1300
    167 N7763d64ba2e84aff85f30a3cb29d32cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Erythropoiesis
    169 rdf:type schema:DefinedTerm
    170 N7f61282807b94fa28581939f6569ba3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Mice
    172 rdf:type schema:DefinedTerm
    173 N84384d653d7f48838364a659a3191035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Humans
    175 rdf:type schema:DefinedTerm
    176 N848428d8578b46f98d57f3fceb4e79ef schema:name dimensions_id
    177 schema:value pub.1092237073
    178 rdf:type schema:PropertyValue
    179 N848a61c5efff4fa0b985a312a10521d1 rdf:first sg:person.01020324730.23
    180 rdf:rest Nba80c3babf9649a099d199c8876df560
    181 N934117e2686640db8155211a45ad91be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Female
    183 rdf:type schema:DefinedTerm
    184 N9992e411c94e441e93580fbe390910b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Animals
    186 rdf:type schema:DefinedTerm
    187 N9bb760b724474aa59ea20562ea955640 rdf:first sg:person.01034312621.30
    188 rdf:rest Nb3e31efad42443f88b6ed6396641d67b
    189 Na41dc7c503684b0cae70676aeef64153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Young Adult
    191 rdf:type schema:DefinedTerm
    192 Na4faefd57147400cab5fc7ae828741e1 rdf:first sg:person.01175600300.57
    193 rdf:rest N445ad8a8909a4a74bb1b3d17ad2d95c5
    194 Na6c73024f77f479699e6fde69a73a666 schema:name Springer Nature - SN SciGraph project
    195 rdf:type schema:Organization
    196 Na7d57868704542d19d39be5b6c15dd17 rdf:first sg:person.0613106413.41
    197 rdf:rest N08be44457dc245289b1318b050cd525b
    198 Nabb62a7402434532a6d43ba7f60e8ce3 schema:name pubmed_id
    199 schema:value 29035359
    200 rdf:type schema:PropertyValue
    201 Nb3e31efad42443f88b6ed6396641d67b rdf:first sg:person.01241456532.17
    202 rdf:rest N7350c0f0313345f8b0f776cc3a832f90
    203 Nb8200c07804042c28aceb87e40e8c4a1 rdf:first sg:person.01007176771.36
    204 rdf:rest Nf9737c359ff9407f9ffeff20a7bb1156
    205 Nba80c3babf9649a099d199c8876df560 rdf:first sg:person.01045256371.95
    206 rdf:rest Nb8200c07804042c28aceb87e40e8c4a1
    207 Nc23004fe7330447cadba42d0cecf4be4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Adipocytes
    209 rdf:type schema:DefinedTerm
    210 Nc3917883c42248bca79a5a554c91f08c rdf:first sg:person.01214636131.57
    211 rdf:rest N4b7d18a2966147319d1d8de0194877a1
    212 Nc7a5e17408ea4fc7a48148810f39b62a rdf:first sg:person.0732602775.37
    213 rdf:rest N848a61c5efff4fa0b985a312a10521d1
    214 Nc8267d26a0864389960d9783886e67e8 schema:volumeNumber 19
    215 rdf:type schema:PublicationVolume
    216 Nca82bde1586944208926deb402387469 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Leukemia, Myeloid, Acute
    218 rdf:type schema:DefinedTerm
    219 Nccbcb5e1b4e84adf93aec247d1b3e039 schema:name readcube_id
    220 schema:value da736358506e915d8ffe7678d7471c398fe2db70bf603af83181bf6e8f6bfb3c
    221 rdf:type schema:PropertyValue
    222 Nd482571a9bb0458a9c98879ce63ce45d schema:affiliation https://www.grid.ac/institutes/grid.21613.37
    223 schema:familyName Jackson
    224 schema:givenName Michael F.
    225 rdf:type schema:Person
    226 Nd71e5e08b3dc453ab7600ce745289456 schema:name nlm_unique_id
    227 schema:value 100890575
    228 rdf:type schema:PropertyValue
    229 Ne715e92d95564980a7f1f818cb647386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Middle Aged
    231 rdf:type schema:DefinedTerm
    232 Nf232b5a7ce5643d9a84a5afe66625d5c schema:name doi
    233 schema:value 10.1038/ncb3625
    234 rdf:type schema:PropertyValue
    235 Nf9737c359ff9407f9ffeff20a7bb1156 rdf:first sg:person.011526062323.70
    236 rdf:rest Na4faefd57147400cab5fc7ae828741e1
    237 Nffa2944bc63b4fd9932e93e1b39d087f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Aged
    239 rdf:type schema:DefinedTerm
    240 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    241 schema:name Medical and Health Sciences
    242 rdf:type schema:DefinedTerm
    243 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    244 schema:name Cardiorespiratory Medicine and Haematology
    245 rdf:type schema:DefinedTerm
    246 sg:journal.1021344 schema:issn 1465-7392
    247 1476-4679
    248 schema:name Nature Cell Biology
    249 rdf:type schema:Periodical
    250 sg:person.010035672317.19 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    251 schema:familyName Reid
    252 schema:givenName Jennifer C.
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010035672317.19
    254 rdf:type schema:Person
    255 sg:person.01007176771.36 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    256 schema:familyName Shapovalova
    257 schema:givenName Zoya
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007176771.36
    259 rdf:type schema:Person
    260 sg:person.01014244717.82 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    261 schema:familyName Leber
    262 schema:givenName Brian
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014244717.82
    264 rdf:type schema:Person
    265 sg:person.01020324730.23 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    266 schema:familyName Aslostovar
    267 schema:givenName Lili
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020324730.23
    269 rdf:type schema:Person
    270 sg:person.01034312621.30 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
    271 schema:familyName Sabloff
    272 schema:givenName Mitchell
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034312621.30
    274 rdf:type schema:Person
    275 sg:person.01045256371.95 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    276 schema:familyName Benoit
    277 schema:givenName Yannick D.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045256371.95
    279 rdf:type schema:Person
    280 sg:person.010471603052.51 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
    281 schema:familyName Allan
    282 schema:givenName David S.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010471603052.51
    284 rdf:type schema:Person
    285 sg:person.011526062323.70 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    286 schema:familyName Nakanishi
    287 schema:givenName Mio
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011526062323.70
    289 rdf:type schema:Person
    290 sg:person.01160110173.62 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    291 schema:familyName Bhatia
    292 schema:givenName Mickie
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160110173.62
    294 rdf:type schema:Person
    295 sg:person.01175600300.57 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    296 schema:familyName Porras
    297 schema:givenName Deanna P.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175600300.57
    299 rdf:type schema:Person
    300 sg:person.01214636131.57 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    301 schema:familyName Campbell
    302 schema:givenName Clinton J. V.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214636131.57
    304 rdf:type schema:Person
    305 sg:person.01223240534.95 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    306 schema:familyName Foley
    307 schema:givenName Ronan
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223240534.95
    309 rdf:type schema:Person
    310 sg:person.01241456532.17 schema:affiliation https://www.grid.ac/institutes/grid.39381.30
    311 schema:familyName Xenocostas
    312 schema:givenName Anargyros
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241456532.17
    314 rdf:type schema:Person
    315 sg:person.01275006705.48 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    316 schema:familyName Almakadi
    317 schema:givenName Mohammed
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275006705.48
    319 rdf:type schema:Person
    320 sg:person.0613106413.41 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    321 schema:familyName Boyd
    322 schema:givenName Allison L.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613106413.41
    324 rdf:type schema:Person
    325 sg:person.0634337371.00 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    326 schema:familyName Collins
    327 schema:givenName Tony J.
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634337371.00
    329 rdf:type schema:Person
    330 sg:person.0732602775.37 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    331 schema:familyName Salci
    332 schema:givenName Kyle R.
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732602775.37
    334 rdf:type schema:Person
    335 sg:pub.10.1007/s00223-013-9753-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029084340
    336 https://doi.org/10.1007/s00223-013-9753-3
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/s11033-013-2623-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023959755
    339 https://doi.org/10.1007/s11033-013-2623-2
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/s11899-016-0346-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045125078
    342 https://doi.org/10.1007/s11899-016-0346-x
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
    345 https://doi.org/10.1038/367645a0
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/cdd.2015.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033921991
    348 https://doi.org/10.1038/cdd.2015.168
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nature02040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509222
    351 https://doi.org/10.1038/nature02040
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nature02041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033616640
    354 https://doi.org/10.1038/nature02041
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nature06902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047374084
    357 https://doi.org/10.1038/nature06902
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nature07639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018866560
    360 https://doi.org/10.1038/nature07639
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nature08099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011517403
    363 https://doi.org/10.1038/nature08099
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nature09262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022774714
    366 https://doi.org/10.1038/nature09262
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nature11885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038795491
    369 https://doi.org/10.1038/nature11885
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/nature12883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016677250
    372 https://doi.org/10.1038/nature12883
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/nature12984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045199334
    375 https://doi.org/10.1038/nature12984
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ncb3570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090747965
    378 https://doi.org/10.1038/ncb3570
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/nchembio.1367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045763666
    381 https://doi.org/10.1038/nchembio.1367
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/ncomms8808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003648329
    384 https://doi.org/10.1038/ncomms8808
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nm0797-730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022333282
    387 https://doi.org/10.1038/nm0797-730
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/srep23479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047157417
    390 https://doi.org/10.1038/srep23479
    391 rdf:type schema:CreativeWork
    392 https://app.dimensions.ai/details/publication/pub.1076951317 schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1082600667 schema:CreativeWork
    394 https://doi.org/10.1002/jcb.22289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053551159
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1002/jcb.22793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043286678
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1002/jcla.20001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013939475
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1002/jcp.24954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049703137
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1002/stem.2208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942819
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/j.devcel.2014.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034784444
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/j.exphem.2013.05.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040593693
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.stem.2013.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014359323
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.stem.2013.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049754164
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.stem.2014.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006485513
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.stem.2014.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022343554
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.stem.2016.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018825035
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.stem.2017.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084109665
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.stemcr.2016.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022752029
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.tem.2016.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050438049
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.yexcr.2016.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044003649
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/s0140-6736(06)69780-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046790794
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1073/pnas.1301891110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004594215
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1084/jem.20140131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011980281
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1093/toxsci/kfr140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026304424
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1097/moh.0000000000000055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005096725
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1097/moh.0000000000000133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965004
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1101/cshperspect.a011668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014404832
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1111/j.1365-2184.2009.00661.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003796794
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1111/j.1365-2443.2009.01281.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007907604
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1152/ajpgi.00265.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000958132
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1158/0008-5472.can-09-1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023177633
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1172/jci64745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037650489
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1182/blood-2005-06-2325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022303201
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1182/blood-2009-07-235358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042177075
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1182/blood-2011-04-348151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034822951
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1182/blood-2013-07-517219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020671091
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1182/blood-2014-11-570218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042684547
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1182/blood-2016-08-734798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123315
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1182/blood-2016-11-696070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083534677
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1371/journal.pone.0046483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015164984
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1371/journal.pone.0090639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029760820
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.18632/oncotarget.7964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020874829
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.2337/db11-1293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003960919
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.2337/diabetes.48.7.1415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070744225
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.3389/fendo.2016.00085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033926636
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.7150/ijms.4476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034885001
    479 rdf:type schema:CreativeWork
    480 https://www.grid.ac/institutes/grid.21613.37 schema:alternateName University of Manitoba
    481 schema:name Central Animal Core Imaging and Transgenic Facilities, Central Animal Care Services, Rady Faculty of Health Sciences, University of Manitoba, 710 William Avenue, SR426 Winnipeg, Manitoba R3E 0Z3, Canada
    482 rdf:type schema:Organization
    483 https://www.grid.ac/institutes/grid.25073.33 schema:alternateName McMaster University
    484 schema:name Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    485 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada
    486 Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    487 rdf:type schema:Organization
    488 https://www.grid.ac/institutes/grid.39381.30 schema:alternateName Western University
    489 schema:name Department of Medicine, Division of Hematology, Schulich School of Medicine, University of Western Ontario, London, Ontario N6A 3K7, Canada
    490 rdf:type schema:Organization
    491 https://www.grid.ac/institutes/grid.412687.e schema:alternateName Ottawa Hospital
    492 schema:name Department of Medicine, Division of Hematology, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada
    493 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...