NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-14

AUTHORS

Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P. White, Yu-Hua Tseng, Aaron M. Cypess, Therese J. Larsen, Naja Z. Jespersen, Camilla Scheele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi, Takashi Kadowaki

ABSTRACT

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions. NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific enhancers. Moreover, the binding of NFIA precedes and facilitates the binding of PPARγ, leading to increased chromatin accessibility and active transcription. Introduction of NFIA into myoblasts results in brown adipocyte differentiation. Conversely, the brown fat of NFIA-knockout mice displays impaired expression of the brown-fat-specific genes and reciprocal elevation of muscle genes. Finally, expression of NFIA and the brown-fat-specific genes is positively correlated in human brown fat. These results indicate that NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARγ to control the brown fat gene program. More... »

PAGES

1081-1092

References to SciGraph publications

  • 2013-11-06. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex in NATURE
  • 2008-09-17. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2008-12-18. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2009-07-29. Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex in NATURE
  • 2015-07-06. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus in NATURE MEDICINE
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2013-04-21. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat in NATURE MEDICINE
  • 2016-12-21. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity in NATURE
  • 2015-10-26. Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo in NATURE GENETICS
  • 2011-08-22. Cistrome: an integrative platform for transcriptional regulation studies in GENOME BIOLOGY
  • 2013-09-29. Brown and beige fat: development, function and therapeutic potential in NATURE MEDICINE
  • 2006-05. GenePattern 2.0 in NATURE GENETICS
  • 2013-10-06. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position in NATURE METHODS
  • 2008-08. PRDM16 controls a brown fat/skeletal muscle switch in NATURE
  • 2017-02-09. Dissecting the brown adipogenic regulatory network using integrative genomics in SCIENTIFIC REPORTS
  • Journal

    TITLE

    Nature Cell Biology

    ISSUE

    9

    VOLUME

    19

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb3590

    DOI

    http://dx.doi.org/10.1038/ncb3590

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091211272

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28812581


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