Ontology type: schema:ScholarlyArticle Open Access: True
2015-09
AUTHORSAntonis Kourtidis, Siu P Ngok, Pamela Pulimeno, Ryan W Feathers, Lomeli R Carpio, Tiffany R Baker, Jennifer M Carr, Irene K Yan, Sahra Borges, Edith A Perez, Peter Storz, John A Copland, Tushar Patel, E Aubrey Thompson, Sandra Citi, Panos Z Anastasiadis
ABSTRACTE-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src. Recruitment of DROSHA and DGCR8 to the ZA is PLEKHA7 dependent. The PLEKHA7-microprocessor complex co-precipitates with primary microRNAs (pri-miRNAs) and possesses pri-miRNA processing activity. PLEKHA7 regulates the levels of select miRNAs, in particular processing of miR-30b, to suppress expression of cell transforming markers promoted by the basolateral complex, including SNAI1, MYC and CCND1. Our work identifies a mechanism through which adhesion complexes regulate cellular behaviour and reveals their surprising association with the microprocessor. More... »
PAGES1145-1157
http://scigraph.springernature.com/pub.10.1038/ncb3227
DOIhttp://dx.doi.org/10.1038/ncb3227
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011165680
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26302406
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adherens Junctions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caco-2 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cadherins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carrier Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Catenins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dogs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Madin Darby Canine Kidney Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "MicroRNAs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Transport",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA Interference",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA Processing, Post-Transcriptional",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA-Binding Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ribonuclease III",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "src-Family Kinases",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Kourtidis",
"givenName": "Antonis",
"id": "sg:person.01214653621.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214653621.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Ngok",
"givenName": "Siu P",
"id": "sg:person.01140244004.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140244004.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Geneva",
"id": "https://www.grid.ac/institutes/grid.8591.5",
"name": [
"Department of Molecular Biology, University of Geneva, 30\u00a0quai Ernest-Ansermet, CH-1211, Geneva\u00a04, Switzerland."
],
"type": "Organization"
},
"familyName": "Pulimeno",
"givenName": "Pamela",
"id": "sg:person.0665212105.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665212105.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Feathers",
"givenName": "Ryan W",
"id": "sg:person.01371120673.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371120673.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Carpio",
"givenName": "Lomeli R",
"id": "sg:person.01213161410.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213161410.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Baker",
"givenName": "Tiffany R",
"id": "sg:person.01003320667.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003320667.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Carr",
"givenName": "Jennifer M",
"id": "sg:person.01254667441.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254667441.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Yan",
"givenName": "Irene K",
"id": "sg:person.01364300506.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364300506.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Borges",
"givenName": "Sahra",
"id": "sg:person.01017564246.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017564246.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Division of Hematology/Oncology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Perez",
"givenName": "Edith A",
"id": "sg:person.01151215137.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151215137.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Storz",
"givenName": "Peter",
"id": "sg:person.01143254101.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143254101.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Copland",
"givenName": "John A",
"id": "sg:person.01037001241.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037001241.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Patel",
"givenName": "Tushar",
"id": "sg:person.0710356531.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710356531.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Thompson",
"givenName": "E Aubrey",
"id": "sg:person.012362237257.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012362237257.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Geneva",
"id": "https://www.grid.ac/institutes/grid.8591.5",
"name": [
"Department of Cell Biology and Institute of Genetics and Genomics of Geneva, University of Geneva, 30\u00a0quai Ernest-Ansermet, CH-1211, Geneva\u00a04, Switzerland."
],
"type": "Organization"
},
"familyName": "Citi",
"givenName": "Sandra",
"id": "sg:person.0723666214.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723666214.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.417467.7",
"name": [
"Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500\u00a0San Pablo Road, Jacksonville, Florida\u00a032224, USA."
],
"type": "Organization"
},
"familyName": "Anastasiadis",
"givenName": "Panos Z",
"id": "sg:person.012060160257.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012060160257.70"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1083/jcb.130.2.355",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000884879"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbamem.2007.12.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001151934"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2353/ajpath.2009.080523",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002085134"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1861409",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002343246"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.abb.2011.10.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003616954"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.25336",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004080358"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.25336",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004080358"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci41695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005097459"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2011.02.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006658606"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m112.370999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006943657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m113.453464",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007796352"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01957",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007929702",
"https://doi.org/10.1038/nature01957"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01957",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007929702",
"https://doi.org/10.1038/nature01957"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009764769",
"https://doi.org/10.1038/ncb2072"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009764769",
"https://doi.org/10.1038/ncb2072"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0022102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010360555"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.148.1.189",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013321235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.148.1.189",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013321235"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm3838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014084316",
"https://doi.org/10.1038/nrm3838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.09.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014313145"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015411207",
"https://doi.org/10.1038/nature03120"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015411207",
"https://doi.org/10.1038/nature03120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/jcs.01001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015596538"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200205115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019918691"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020586906",
"https://doi.org/10.1038/ncb1173"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020586906",
"https://doi.org/10.1038/ncb1173"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03552",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020637207",
"https://doi.org/10.1038/nature03552"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03552",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020637207",
"https://doi.org/10.1038/nature03552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-4000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021171147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jclinpath-2011-200516",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023565195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbcan.2012.03.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023643486"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2014.06.043",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024757065"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m110.136770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025282107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0013665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025475794"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-biochem-060308-103103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027450088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.141.3.779",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027890571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200807096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028518950"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2843",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028796698",
"https://doi.org/10.1038/nrg2843"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.09.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029127895"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m102443200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030959564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200805113",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031060983"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2011.12.121",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032665005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0012207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032891722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1231197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033853301"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1231197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033853301"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2009.08.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034955298"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1115079",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037353410"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200605022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039362027"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2634",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040605557",
"https://doi.org/10.1038/nrg2634"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2634",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040605557",
"https://doi.org/10.1038/nrg2634"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041303476",
"https://doi.org/10.1038/ncb1900"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1900",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041303476",
"https://doi.org/10.1038/ncb1900"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2011.220",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041437160",
"https://doi.org/10.1038/bjc.2011.220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btq675",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041937331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1262504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042334541"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.9.2.629",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044901376"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200510087",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045480162"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0016206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046052611"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m111.230862",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047594006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2010.01.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048907513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2010.01.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048907513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbamcr.2006.08.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049525250"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-12-394311-8.00018-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049546455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e11-06-0497",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050781465"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200307111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051403043"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051617993",
"https://doi.org/10.1038/ncb1508"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051617993",
"https://doi.org/10.1038/ncb1508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/isl.1.2.9578",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072305025"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/tisb.28755",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072311095"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074752656",
"type": "CreativeWork"
}
],
"datePublished": "2015-09",
"datePublishedReg": "2015-09-01",
"description": "E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src. Recruitment of DROSHA and DGCR8 to the ZA is PLEKHA7\u00a0dependent. The PLEKHA7-microprocessor complex co-precipitates with primary microRNAs (pri-miRNAs) and possesses pri-miRNA processing activity. PLEKHA7 regulates the levels of select miRNAs, in particular processing of miR-30b, to suppress expression of cell transforming markers promoted by the basolateral complex, including SNAI1, MYC and CCND1. Our work identifies a mechanism through which adhesion complexes regulate cellular behaviour and reveals their surprising association with the microprocessor. ",
"genre": "research_article",
"id": "sg:pub.10.1038/ncb3227",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2476673",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2520265",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2477079",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2562733",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2440217",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2480131",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1021344",
"issn": [
"1465-7392",
"1476-4679"
],
"name": "Nature Cell Biology",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "17"
}
],
"name": "Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity",
"pagination": "1145-1157",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"35327dbf961b664b5224f9f74e76935c803aa941a9df20779dad78c6fbd16db8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26302406"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100890575"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ncb3227"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1011165680"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ncb3227",
"https://app.dimensions.ai/details/publication/pub.1011165680"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000422.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/ncb/journal/v17/n9/full/ncb3227.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb3227'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb3227'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb3227'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb3227'
This table displays all metadata directly associated to this object as RDF triples.
439 TRIPLES
21 PREDICATES
103 URIs
37 LITERALS
25 BLANK NODES