Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03

AUTHORS

Einav Shoshan, Aaron K. Mobley, Russell R. Braeuer, Takafumi Kamiya, Li Huang, Mayra E. Vasquez, Ahmad Salameh, Ho Jeong Lee, Sun Jin Kim, Cristina Ivan, Guermarie Velazquez-Torres, Ka Ming Nip, Kelsey Zhu, Denise Brooks, Steven J. M. Jones, Inanc Birol, Maribel Mosqueda, Yu-ye Wen, Agda Karina Eterovic, Anil K. Sood, Patrick Hwu, Jeffrey E. Gershenwald, A. Gordon Robertson, George A. Calin, Gal Markel, Isaiah J. Fidler, Menashe Bar-Eli

ABSTRACT

Although recent studies have shown that adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs), its effects on tumour growth and metastasis are not well understood. We present evidence of CREB-mediated low expression of ADAR1 in metastatic melanoma cell lines and tumour specimens. Re-expression of ADAR1 resulted in the suppression of melanoma growth and metastasis in vivo. Consequently, we identified three miRNAs undergoing A-to-I editing in the weakly metastatic melanoma but not in strongly metastatic cell lines. One of these miRNAs, miR-455-5p, has two A-to-I RNA-editing sites. The biological function of edited miR-455-5p is different from that of the unedited form, as it recognizes a different set of genes. Indeed, wild-type miR-455-5p promotes melanoma metastasis through inhibition of the tumour suppressor gene CPEB1. Moreover, wild-type miR-455 enhances melanoma growth and metastasis in vivo, whereas the edited form inhibits these features. These results demonstrate a previously unrecognized role for RNA editing in melanoma progression. More... »

PAGES

311-321

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb3110

DOI

http://dx.doi.org/10.1038/ncb3110

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037204646

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25686251


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