In vivo reprogramming for tissue repair View Full Text


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Article Info

DATE

2015-02-27

AUTHORS

Christophe Heinrich, Francesca M. Spagnoli, Benedikt Berninger

ABSTRACT

Berninger and colleagues define milestones for in vivo reprogramming and discuss recent developments in reprogramming into pancreatic b-cells and neurons.

PAGES

204-211

References to SciGraph publications

  • 2012-12-16. Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18 in NATURE BIOTECHNOLOGY
  • 2014-04-03. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h−/− mouse in GENE THERAPY
  • 2013-01-20. Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo in NATURE CELL BIOLOGY
  • 2012-05-13. Heart repair by reprogramming non-myocytes with cardiac transcription factors in NATURE
  • 2010-10-17. Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo in NATURE NEUROSCIENCE
  • 2001-08. Hepatitis C virus replication in mice with chimeric human livers in NATURE MEDICINE
  • 2011-03-09. Turning straw into gold: directing cell fate for regenerative medicine in NATURE REVIEWS GENETICS
  • 2011-07-13. MicroRNA-mediated conversion of human fibroblasts to neurons in NATURE
  • 2011-02-03. Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex in NATURE PROTOCOLS
  • 2013-03-31. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation in NATURE NEUROSCIENCE
  • 2002-03-18. Glial cells generate neurons: the role of the transcription factor Pax6 in NATURE NEUROSCIENCE
  • 2014-11-24. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts in NATURE NEUROSCIENCE
  • 2010-01-27. Direct conversion of fibroblasts to functional neurons by defined factors in NATURE
  • 2006-10-19. Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2014-09-11. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells in NATURE BIOTECHNOLOGY
  • 2008-08-27. In vivo reprogramming of adult pancreatic exocrine cells to β-cells in NATURE
  • 2013-01-06. In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons in NATURE NEUROSCIENCE
  • 2013-04-28. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain in NATURE NEUROSCIENCE
  • 2004-03-14. Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain in NATURE NEUROSCIENCE
  • 2012-04-18. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes in NATURE
  • 2011-07-03. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts in NATURE
  • 2000-05. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia in NATURE MEDICINE
  • 2013-11-17. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice in NATURE BIOTECHNOLOGY
  • 2014-08-20. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers in NATURE
  • 2008-12-21. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes in NATURE BIOTECHNOLOGY
  • 2010-04-04. Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss in NATURE
  • 2003-04-21. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice in NATURE MEDICINE
  • 2011-01-20. The stem cell potential of glia: lessons from reactive gliosis in NATURE REVIEWS NEUROSCIENCE
  • 2014-02-25. In vivo conversion of astrocytes to neurons in the injured adult spinal cord in NATURE COMMUNICATIONS
  • 2013-08-23. Environmental impact on direct neuronal reprogramming in vivo in the adult brain in NATURE COMMUNICATIONS
  • 2011-10-12. Direct lineage conversions: unnatural but useful? in NATURE BIOTECHNOLOGY
  • 2012-03-11. Generation of functional insulin-producing cells in the gut by Foxo1 ablation in NATURE GENETICS
  • 2012-12-05. Functional screening identifies miRNAs inducing cardiac regeneration in NATURE
  • 2013-09-22. In vivo reprogramming of astrocytes to neuroblasts in the adult brain in NATURE CELL BIOLOGY
  • 2014-07-06. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons in NATURE NEUROSCIENCE
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