Ontology type: schema:ScholarlyArticle Open Access: True
2014-08
AUTHORSNorman Ertych, Ailine Stolz, Albrecht Stenzinger, Wilko Weichert, Silke Kaulfuß, Peter Burfeind, Achim Aigner, Linda Wordeman, Holger Bastians
ABSTRACTChromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer. However, the mechanisms influencing CIN and its consequences on tumour growth are largely unknown. We identified an increase in microtubule plus-end assembly rates as a mechanism influencing CIN in colorectal cancer cells. This phenotype is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in 73% of human colorectal cancers. Increased microtubule assembly rates are associated with transient abnormalities in mitotic spindle geometry promoting the generation of lagging chromosomes and influencing CIN. Reconstitution of proper microtubule assembly rates by chemical or genetic means suppresses CIN and thereby, unexpectedly, accelerates tumour growth in vitro and in vivo. Thus, we identify a fundamental mechanism influencing CIN in cancer cells and reveal its adverse consequence on tumour growth. More... »
PAGES779-791
http://scigraph.springernature.com/pub.10.1038/ncb2994
DOIhttp://dx.doi.org/10.1038/ncb2994
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1039772886
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24976383
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aurora Kinase A",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "BRCA1 Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caco-2 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Checkpoint Kinase 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosomal Instability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosome Segregation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, Tumor Suppressor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HCT116 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HT29 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microtubules",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Biological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogenes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spindle Apparatus",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of G\u00f6ttingen",
"id": "https://www.grid.ac/institutes/grid.7450.6",
"name": [
"Institute of Molecular Oncology, Section for Cellular Oncology, Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center, Georg-August University, D-37077 Goettingen, Germany"
],
"type": "Organization"
},
"familyName": "Ertych",
"givenName": "Norman",
"id": "sg:person.01347144660.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347144660.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of G\u00f6ttingen",
"id": "https://www.grid.ac/institutes/grid.7450.6",
"name": [
"Institute of Molecular Oncology, Section for Cellular Oncology, Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center, Georg-August University, D-37077 Goettingen, Germany"
],
"type": "Organization"
},
"familyName": "Stolz",
"givenName": "Ailine",
"id": "sg:person.01164603060.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164603060.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Institute for Pathology, University Medical Center, Ruprecht-Karls-University, D-69120 Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Stenzinger",
"givenName": "Albrecht",
"id": "sg:person.0642700650.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Institute for Pathology, University Medical Center, Ruprecht-Karls-University, D-69120 Heidelberg, Germany",
"German Consortium for Translational Cancer Research, D-69120 Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Weichert",
"givenName": "Wilko",
"id": "sg:person.0657434205.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Institute for Human Genetics, University Medical Center, Georg-August University, D-37073 Goettingen, Germany"
],
"type": "Organization"
},
"familyName": "Kaulfu\u00df",
"givenName": "Silke",
"id": "sg:person.01117623135.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117623135.15"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Institute for Human Genetics, University Medical Center, Georg-August University, D-37073 Goettingen, Germany"
],
"type": "Organization"
},
"familyName": "Burfeind",
"givenName": "Peter",
"id": "sg:person.0725155715.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725155715.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Leipzig University",
"id": "https://www.grid.ac/institutes/grid.9647.c",
"name": [
"Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, D-04107 Leipzig, Germany"
],
"type": "Organization"
},
"familyName": "Aigner",
"givenName": "Achim",
"id": "sg:person.01342103654.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342103654.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Physiology and Biophysics, University of Washington, School of Medicine, Seattle, Washington 98195, USA"
],
"type": "Organization"
},
"familyName": "Wordeman",
"givenName": "Linda",
"id": "sg:person.01030776750.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030776750.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of G\u00f6ttingen",
"id": "https://www.grid.ac/institutes/grid.7450.6",
"name": [
"Institute of Molecular Oncology, Section for Cellular Oncology, Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center, Georg-August University, D-37077 Goettingen, Germany"
],
"type": "Organization"
},
"familyName": "Bastians",
"givenName": "Holger",
"id": "sg:person.015033462305.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015033462305.44"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.tcb.2011.01.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000496669"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-1215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000573421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.286.5441.971",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001488189"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-2264(200002)27:2<183::aid-gcc10>3.0.co;2-p",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002252628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/embor.2012.65",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003493613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2007.11.043",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004479753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.245603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005344723"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0608798104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007885692"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008762596",
"https://doi.org/10.1038/ncb1809"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11935",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009189689",
"https://doi.org/10.1038/nature11935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2004.01.055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011823078"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2006.07.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012083071"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1534-5807(04)00025-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013747011"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014080321",
"https://doi.org/10.1038/nrc1165"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014080321",
"https://doi.org/10.1038/nrc1165"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014745794",
"https://doi.org/10.1038/nature08136"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014745794",
"https://doi.org/10.1038/nature08136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0308205100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015053551"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/2496",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016917923",
"https://doi.org/10.1038/2496"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/2496",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016917923",
"https://doi.org/10.1038/2496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cm.20510",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017507818"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1142210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018543968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.202606599",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018741894"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019371971",
"https://doi.org/10.1038/nrc2964"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019371971",
"https://doi.org/10.1038/nrc2964"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020709483",
"https://doi.org/10.1038/nrc1317"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020709483",
"https://doi.org/10.1038/nrc1317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200503023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021580862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200503023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021580862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/17.11.3052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022175488"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m213159200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023399987"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg3123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023417946",
"https://doi.org/10.1038/nrg3123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.153.3.517",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023552588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.105.5.2203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025390038"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/hsz-2013-0184",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025864072"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200707120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027031050"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35070123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027104291",
"https://doi.org/10.1038/35070123"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35070123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027104291",
"https://doi.org/10.1038/35070123"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2012.616",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028735655",
"https://doi.org/10.1038/onc.2012.616"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207860",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028786621",
"https://doi.org/10.1038/sj.onc.1207860"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1207860",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028786621",
"https://doi.org/10.1038/sj.onc.1207860"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jsb.2011.07.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029613599"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.08.053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032863149"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-006-0254-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035260011",
"https://doi.org/10.1007/s00280-006-0254-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-006-0254-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035260011",
"https://doi.org/10.1007/s00280-006-0254-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35004614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036352993",
"https://doi.org/10.1038/35004614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35004614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036352993",
"https://doi.org/10.1038/35004614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.200911120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036398464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2010.01.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038205886"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039157951",
"https://doi.org/10.1038/sj.onc.1209707"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039157951",
"https://doi.org/10.1038/sj.onc.1209707"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042708958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fonc.2013.00164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042993685"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/jcs.00716",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046157623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tig.2011.07.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046358332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2009.09.055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046621574"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0006564",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050356255"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1995.406_b.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050404184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.05.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050620955"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(08)70004-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050899832"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb2051",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050909369",
"https://doi.org/10.1038/ncb2051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra0804588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050986835"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/embor.2012.61",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052716727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1145720",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053548183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1160058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062458400"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v11.i36.5644",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071363668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.23-07-02655.2003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075266247"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076820315",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083232625",
"type": "CreativeWork"
}
],
"datePublished": "2014-08",
"datePublishedReg": "2014-08-01",
"description": "Chromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer. However, the mechanisms influencing CIN and its consequences on tumour growth are largely unknown. We identified an increase in microtubule plus-end assembly rates as a mechanism influencing CIN in colorectal cancer cells. This phenotype is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in 73% of human colorectal cancers. Increased microtubule assembly rates are associated with transient abnormalities in mitotic spindle geometry promoting the generation of lagging chromosomes and influencing CIN. Reconstitution of proper microtubule assembly rates by chemical or genetic means suppresses CIN and thereby, unexpectedly, accelerates tumour growth in vitro and in vivo. Thus, we identify a fundamental mechanism influencing CIN in cancer cells and reveal its adverse consequence on tumour growth. ",
"genre": "research_article",
"id": "sg:pub.10.1038/ncb2994",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2518131",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3537446",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1021344",
"issn": [
"1465-7392",
"1476-4679"
],
"name": "Nature Cell Biology",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"name": "Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells",
"pagination": "779-791",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"bd76132adecd8a0c6586eacbe2e8d417aa6a6a1aba6baba7df6e5bd4cb7944e6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24976383"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100890575"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ncb2994"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1039772886"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ncb2994",
"https://app.dimensions.ai/details/publication/pub.1039772886"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000425.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/ncb2994"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb2994'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb2994'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb2994'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb2994'
This table displays all metadata directly associated to this object as RDF triples.
398 TRIPLES
21 PREDICATES
104 URIs
38 LITERALS
26 BLANK NODES