Causes and consequences of replication stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01

AUTHORS

Michelle K Zeman, Karlene A Cimprich

ABSTRACT

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress. More... »

PAGES

2-9

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    http://scigraph.springernature.com/pub.10.1038/ncb2897

    DOI

    http://dx.doi.org/10.1038/ncb2897

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049104507

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24366029


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