DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05

AUTHORS

Christian G. Riedel, Robert H. Dowen, Guinevere F. Lourenco, Natalia V. Kirienko, Thomas Heimbucher, Jason A. West, Sarah K. Bowman, Robert E. Kingston, Andrew Dillin, John M. Asara, Gary Ruvkun

ABSTRACT

Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses, but despite its importance little is known about how it regulates its target genes. Proteomic identification of DAF-16/FOXO-binding partners in Caenorhabditis elegans and their subsequent functional evaluation by RNA interference revealed several candidate DAF-16/FOXO cofactors, most notably the chromatin remodeller SWI/SNF. DAF-16/FOXO and SWI/SNF form a complex and globally co-localize at DAF-16/FOXO target promoters. We show that specifically for gene activation, DAF-16/FOXO depends on SWI/SNF, facilitating SWI/SNF recruitment to target promoters, to activate transcription by presumed remodelling of local chromatin. For the animal, this translates into an essential role for SWI/SNF in DAF-16/FOXO-mediated processes, in particular dauer formation, stress resistance and the promotion of longevity. Thus, we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation. More... »

PAGES

491

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2720

    DOI

    http://dx.doi.org/10.1038/ncb2720

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008428712

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23604319


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