Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

R. Wollman, T. Meyer

ABSTRACT

The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(2) lipid levels that in turn drive cyclic recruitment of N-WASP and cortical actin level oscillations. Experimental and computational analysis argues that vesicle fusion correlates with the observed actin and Ca(2+) level oscillations. A vesicle secretion cycle starts with the capture of vesicles by actin when cortical F-actin levels are high, followed by vesicle passage through the cortex when F-actin levels are low, and vesicle fusion with the plasma membrane when Ca(2+) levels subsequently increase. Thus, cells employ oscillating levels of Ca(2+), PtdIns(4,5)P(2) and cortical F-actin to increase secretion efficiency, explaining how the actin cortex can function as a carrier as well as barrier for vesicle secretion. More... »

PAGES

1261

References to SciGraph publications

  • 2000-05. Tracking chromaffin granules on their way through the actin cortex in EUROPEAN BIOPHYSICS JOURNAL
  • 2002-07. Synaptotagmin: A Ca2+ sensor that triggers exocytosis? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-08. Cytoskeletal regulation: rich in lipids in NATURE REVIEWS MOLECULAR CELL BIOLOGY
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    http://scigraph.springernature.com/pub.10.1038/ncb2614

    DOI

    http://dx.doi.org/10.1038/ncb2614

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016668494

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23143397


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