Dll1+ secretory progenitor cells revert to stem cells upon crypt damage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Johan H. van Es, Toshiro Sato, Marc van de Wetering, Anna Lyubimova, Annie Ng Yee Nee, Alex Gregorieff, Nobuo Sasaki, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Anton C. M. Martens, Nick Barker, Alexander van Oudenaarden, Hans Clevers

ABSTRACT

Lgr5+ intestinal stem cells generate enterocytes and secretory cells. Secretory lineage commitment requires Notch silencing. The Notch ligand Dll1 is expressed by a subset of immediate stem cell daughters. Lineage tracing in Dll1(GFP-ires-CreERT2) knock-in mice reveals that single Dll1(high) cells generate small, short-lived clones containing all four secretory cell types. Lineage specification thus occurs in immediate stem cell daughters through Notch lateral inhibition. Cultured Dll1(high) cells form long-lived organoids (mini-guts) on brief Wnt3A exposure. When Dll1(high) cells are genetically marked before tissue damage, stem cell tracing events occur. Thus, secretory progenitors exhibit plasticity by regaining stemness on damage. More... »

PAGES

1099

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb2581

DOI

http://dx.doi.org/10.1038/ncb2581

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011110264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23000963


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