Molecular control of animal cell cytokinesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-02

AUTHORS

Juan Pablo Fededa, Daniel W. Gerlich

ABSTRACT

Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells. More... »

PAGES

440-447

References to SciGraph publications

  • 2004-07-28. Cell cycle regulation of central spindle assembly in NATURE
  • 2007-05-09. Experimental and theoretical study of mitotic spindle orientation in NATURE
  • 2007-12. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin in NATURE
  • 2011-09-11. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity in NATURE CELL BIOLOGY
  • 2010-06-30. Membrane budding and scission by the ESCRT machinery: it's all in the neck in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-06-07. A mechanism linking extra centrosomes to chromosomal instability in NATURE
  • 2010-03-07. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody in NATURE CELL BIOLOGY
  • 2003-08-06. Determining the position of the cell division plane in NATURE
  • 2009-03-08. A mechanism for chromosome segregation sensing by the NoCut checkpoint in NATURE CELL BIOLOGY
  • 2011-07-13. Phosphatases: providing safe passage through mitotic exit in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-12-14. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis in NATURE CELL BIOLOGY
  • 2005-10. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells in NATURE
  • 2008-07-06. The regulated assembly of a PKCɛ complex controls the completion of cytokinesis in NATURE CELL BIOLOGY
  • 2008-12-07. Regulation of cytokinesis by Rho GTPase flux in NATURE CELL BIOLOGY
  • 2011-08-07. Polar actomyosin contractility destabilizes the position of the cytokinetic furrow in NATURE
  • 2011-06-26. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis in NATURE CELL BIOLOGY
  • 2008-05-07. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient in NATURE
  • 2009-02-22. Membrane scission by the ESCRT-III complex in NATURE
  • 2009-01. The 3Ms of central spindle assembly: microtubules, motors and MAPs in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-08. A cytokinesis furrow is positioned by two consecutive signals in NATURE
  • 2011-06-12. External forces control mitotic spindle positioning in NATURE CELL BIOLOGY
  • 2011-09. Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour in NATURE COMMUNICATIONS
  • 2008-11-09. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-03-11. Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1 in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2482

    DOI

    http://dx.doi.org/10.1038/ncb2482

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013610460

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22552143


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokinesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spindle Apparatus", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.417521.4", 
              "name": [
                "Juan Pablo Fededa and Daniel W. Gerlich: Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, CH-8093 Zurich, Switzerland", 
                "Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fededa", 
            "givenName": "Juan Pablo", 
            "id": "sg:person.0665450470.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665450470.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.417521.4", 
              "name": [
                "Juan Pablo Fededa and Daniel W. Gerlich: Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, CH-8093 Zurich, Switzerland", 
                "Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerlich", 
            "givenName": "Daniel W.", 
            "id": "sg:person.0747122405.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747122405.80"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ncb2332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025118706", 
              "https://doi.org/10.1038/ncb2332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052404555", 
              "https://doi.org/10.1038/nrm2937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004624308", 
              "https://doi.org/10.1038/nrm2609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025185317", 
              "https://doi.org/10.1038/ncb1855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046208104", 
              "https://doi.org/10.1038/ncb2279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052225982", 
              "https://doi.org/10.1038/ncb1813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029433563", 
              "https://doi.org/10.1038/nature05786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043751695", 
              "https://doi.org/10.1038/ncb1749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031420354", 
              "https://doi.org/10.1038/nrm3149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026140008", 
              "https://doi.org/10.1038/nature07836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021697546", 
              "https://doi.org/10.1038/ncb1814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593377", 
              "https://doi.org/10.1038/nature10286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014371423", 
              "https://doi.org/10.1038/nature03823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015077580", 
              "https://doi.org/10.1038/ncb2036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019534278", 
              "https://doi.org/10.1038/ncomms1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014745794", 
              "https://doi.org/10.1038/nature08136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004978167", 
              "https://doi.org/10.1038/ncb2269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010033854", 
              "https://doi.org/10.1038/nature06923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043261736", 
              "https://doi.org/10.1038/nature04217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007513084", 
              "https://doi.org/10.1038/nsmb.1512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020951056", 
              "https://doi.org/10.1038/nature01860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034515712", 
              "https://doi.org/10.1038/ncb1557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036207255", 
              "https://doi.org/10.1038/nature06388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028674311", 
              "https://doi.org/10.1038/nature02767"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-05-02", 
        "datePublishedReg": "2012-05-02", 
        "description": "Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ncb2482", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3783981", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3788136", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021344", 
            "issn": [
              "1465-7392", 
              "1476-4679"
            ], 
            "name": "Nature Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "keywords": [
          "animal cell cytokinesis", 
          "cell cytokinesis", 
          "actomyosin ring assembly", 
          "division plane specification", 
          "underlying molecular mechanisms", 
          "molecular signaling pathways", 
          "biochemical reconstitution", 
          "chromosome segregation", 
          "faithful partitioning", 
          "chemical genetics", 
          "daughter cells", 
          "animal cells", 
          "molecular control", 
          "cytokinetic furrow", 
          "plasma membrane", 
          "cytokinesis", 
          "ring assembly", 
          "mitotic cells", 
          "molecular mechanisms", 
          "biophysical methodologies", 
          "signaling pathways", 
          "cytological events", 
          "plane specification", 
          "recent insights", 
          "molecular factors", 
          "distinct steps", 
          "abscission", 
          "cells", 
          "genome", 
          "recent progress", 
          "genetics", 
          "pathway", 
          "membrane", 
          "assembly", 
          "reconstitution", 
          "furrow", 
          "refined model", 
          "segregation", 
          "reorganization", 
          "insights", 
          "events", 
          "mechanism", 
          "partitioning", 
          "understanding", 
          "microscopy", 
          "factors", 
          "step", 
          "progress", 
          "process", 
          "control", 
          "individual events", 
          "contraction", 
          "specification", 
          "years", 
          "model", 
          "methodology"
        ], 
        "name": "Molecular control of animal cell cytokinesis", 
        "pagination": "440-447", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1013610460"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncb2482"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22552143"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncb2482", 
          "https://app.dimensions.ai/details/publication/pub.1013610460"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_583.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ncb2482"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb2482'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb2482'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb2482'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb2482'


     

    This table displays all metadata directly associated to this object as RDF triples.

    241 TRIPLES      21 PREDICATES      109 URIs      76 LITERALS      10 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncb2482 schema:about N23632096c7724a69a194411b7f683634
    2 Nfc1a3313b7324bc8875488e0a46cc370
    3 Nfc4056c7e553446e9305d9336f9df374
    4 anzsrc-for:06
    5 anzsrc-for:0601
    6 anzsrc-for:0604
    7 schema:author N27df9264b7404a83bc38ab4d87523ba4
    8 schema:citation sg:pub.10.1038/nature01860
    9 sg:pub.10.1038/nature02767
    10 sg:pub.10.1038/nature03823
    11 sg:pub.10.1038/nature04217
    12 sg:pub.10.1038/nature05786
    13 sg:pub.10.1038/nature06388
    14 sg:pub.10.1038/nature06923
    15 sg:pub.10.1038/nature07836
    16 sg:pub.10.1038/nature08136
    17 sg:pub.10.1038/nature10286
    18 sg:pub.10.1038/ncb1557
    19 sg:pub.10.1038/ncb1749
    20 sg:pub.10.1038/ncb1813
    21 sg:pub.10.1038/ncb1814
    22 sg:pub.10.1038/ncb1855
    23 sg:pub.10.1038/ncb2036
    24 sg:pub.10.1038/ncb2269
    25 sg:pub.10.1038/ncb2279
    26 sg:pub.10.1038/ncb2332
    27 sg:pub.10.1038/ncomms1511
    28 sg:pub.10.1038/nrm2609
    29 sg:pub.10.1038/nrm2937
    30 sg:pub.10.1038/nrm3149
    31 sg:pub.10.1038/nsmb.1512
    32 schema:datePublished 2012-05-02
    33 schema:datePublishedReg 2012-05-02
    34 schema:description Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
    35 schema:genre article
    36 schema:isAccessibleForFree false
    37 schema:isPartOf Nb8ef5bcdf8424538843773e4801dbdb1
    38 Ne678b88c0c124e70a1053d45f6380266
    39 sg:journal.1021344
    40 schema:keywords abscission
    41 actomyosin ring assembly
    42 animal cell cytokinesis
    43 animal cells
    44 assembly
    45 biochemical reconstitution
    46 biophysical methodologies
    47 cell cytokinesis
    48 cells
    49 chemical genetics
    50 chromosome segregation
    51 contraction
    52 control
    53 cytokinesis
    54 cytokinetic furrow
    55 cytological events
    56 daughter cells
    57 distinct steps
    58 division plane specification
    59 events
    60 factors
    61 faithful partitioning
    62 furrow
    63 genetics
    64 genome
    65 individual events
    66 insights
    67 mechanism
    68 membrane
    69 methodology
    70 microscopy
    71 mitotic cells
    72 model
    73 molecular control
    74 molecular factors
    75 molecular mechanisms
    76 molecular signaling pathways
    77 partitioning
    78 pathway
    79 plane specification
    80 plasma membrane
    81 process
    82 progress
    83 recent insights
    84 recent progress
    85 reconstitution
    86 refined model
    87 reorganization
    88 ring assembly
    89 segregation
    90 signaling pathways
    91 specification
    92 step
    93 underlying molecular mechanisms
    94 understanding
    95 years
    96 schema:name Molecular control of animal cell cytokinesis
    97 schema:pagination 440-447
    98 schema:productId N28ebc4411b3749abaa76b40be71fb97b
    99 N60e87632c2a6423eb91f18a1bfd220ee
    100 Nb8d0e05788d14692bd46943a921b9ddc
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013610460
    102 https://doi.org/10.1038/ncb2482
    103 schema:sdDatePublished 2022-10-01T06:38
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher N0af1ce02f94c4d7bbb4d9d710589b989
    106 schema:url https://doi.org/10.1038/ncb2482
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N0af1ce02f94c4d7bbb4d9d710589b989 schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N23632096c7724a69a194411b7f683634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Spindle Apparatus
    114 rdf:type schema:DefinedTerm
    115 N27df9264b7404a83bc38ab4d87523ba4 rdf:first sg:person.0665450470.07
    116 rdf:rest N86b37971b1cf4453bc017b9e90c5541a
    117 N28ebc4411b3749abaa76b40be71fb97b schema:name dimensions_id
    118 schema:value pub.1013610460
    119 rdf:type schema:PropertyValue
    120 N60e87632c2a6423eb91f18a1bfd220ee schema:name doi
    121 schema:value 10.1038/ncb2482
    122 rdf:type schema:PropertyValue
    123 N86b37971b1cf4453bc017b9e90c5541a rdf:first sg:person.0747122405.80
    124 rdf:rest rdf:nil
    125 Nb8d0e05788d14692bd46943a921b9ddc schema:name pubmed_id
    126 schema:value 22552143
    127 rdf:type schema:PropertyValue
    128 Nb8ef5bcdf8424538843773e4801dbdb1 schema:issueNumber 5
    129 rdf:type schema:PublicationIssue
    130 Ne678b88c0c124e70a1053d45f6380266 schema:volumeNumber 14
    131 rdf:type schema:PublicationVolume
    132 Nfc1a3313b7324bc8875488e0a46cc370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Animals
    134 rdf:type schema:DefinedTerm
    135 Nfc4056c7e553446e9305d9336f9df374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Cytokinesis
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Biological Sciences
    140 rdf:type schema:DefinedTerm
    141 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    142 schema:name Biochemistry and Cell Biology
    143 rdf:type schema:DefinedTerm
    144 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    145 schema:name Genetics
    146 rdf:type schema:DefinedTerm
    147 sg:grant.3783981 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2482
    148 rdf:type schema:MonetaryGrant
    149 sg:grant.3788136 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2482
    150 rdf:type schema:MonetaryGrant
    151 sg:journal.1021344 schema:issn 1465-7392
    152 1476-4679
    153 schema:name Nature Cell Biology
    154 schema:publisher Springer Nature
    155 rdf:type schema:Periodical
    156 sg:person.0665450470.07 schema:affiliation grid-institutes:grid.417521.4
    157 schema:familyName Fededa
    158 schema:givenName Juan Pablo
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665450470.07
    160 rdf:type schema:Person
    161 sg:person.0747122405.80 schema:affiliation grid-institutes:grid.417521.4
    162 schema:familyName Gerlich
    163 schema:givenName Daniel W.
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747122405.80
    165 rdf:type schema:Person
    166 sg:pub.10.1038/nature01860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020951056
    167 https://doi.org/10.1038/nature01860
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nature02767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028674311
    170 https://doi.org/10.1038/nature02767
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nature03823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014371423
    173 https://doi.org/10.1038/nature03823
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nature04217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043261736
    176 https://doi.org/10.1038/nature04217
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nature05786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029433563
    179 https://doi.org/10.1038/nature05786
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nature06388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036207255
    182 https://doi.org/10.1038/nature06388
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nature06923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010033854
    185 https://doi.org/10.1038/nature06923
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nature07836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026140008
    188 https://doi.org/10.1038/nature07836
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature08136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745794
    191 https://doi.org/10.1038/nature08136
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nature10286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047593377
    194 https://doi.org/10.1038/nature10286
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/ncb1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034515712
    197 https://doi.org/10.1038/ncb1557
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/ncb1749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043751695
    200 https://doi.org/10.1038/ncb1749
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ncb1813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052225982
    203 https://doi.org/10.1038/ncb1813
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ncb1814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697546
    206 https://doi.org/10.1038/ncb1814
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/ncb1855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025185317
    209 https://doi.org/10.1038/ncb1855
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/ncb2036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015077580
    212 https://doi.org/10.1038/ncb2036
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/ncb2269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004978167
    215 https://doi.org/10.1038/ncb2269
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/ncb2279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046208104
    218 https://doi.org/10.1038/ncb2279
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/ncb2332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025118706
    221 https://doi.org/10.1038/ncb2332
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/ncomms1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019534278
    224 https://doi.org/10.1038/ncomms1511
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nrm2609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004624308
    227 https://doi.org/10.1038/nrm2609
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nrm2937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052404555
    230 https://doi.org/10.1038/nrm2937
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nrm3149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031420354
    233 https://doi.org/10.1038/nrm3149
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nsmb.1512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007513084
    236 https://doi.org/10.1038/nsmb.1512
    237 rdf:type schema:CreativeWork
    238 grid-institutes:grid.417521.4 schema:alternateName Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    239 schema:name Juan Pablo Fededa and Daniel W. Gerlich: Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, CH-8093 Zurich, Switzerland
    240 Present address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    241 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...