COPII and the regulation of protein sorting in mammals View Full Text


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Article Info

DATE

2011-12-22

AUTHORS

Giulia Zanetti, Kanika Bajaj Pahuja, Sean Studer, Soomin Shim, Randy Schekman

ABSTRACT

Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout all eukaryotes. Nevertheless, the COPII coat has adapted to the higher complexity of mammalian physiology, achieving more sophisticated levels of secretory regulation. In this review we cover aspects of mammalian COPII-mediated regulation of secretion, in particular related to the function of COPII paralogues, the spatial organization of cargo export and the role of accessory proteins. More... »

PAGES

20-28

References to SciGraph publications

  • 2004-12-05. Coupling of ER exit to microtubules through direct interaction of COPII with dynactin in NATURE CELL BIOLOGY
  • 2009-09-20. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis in NATURE CELL BIOLOGY
  • 2002-09. Structure of the Sec23/24–Sar1 pre-budding complex of the COPII vesicle coat in NATURE
  • 2006-09-17. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation in NATURE GENETICS
  • 2003-04-03. A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21 in HUMAN GENETICS
  • 2007-02-07. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 in NATURE
  • 2001-05-01. Dynamics of the COPII coat with GTP and stable analogues in NATURE CELL BIOLOGY
  • 2005-01-23. Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-05-01. Sequential interactions with Sec23 control the direction of vesicle traffic in NATURE
  • 2009-12-06. Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure in NATURE CELL BIOLOGY
  • 2006-09-17. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking in NATURE GENETICS
  • 2009-06-28. Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II in NATURE GENETICS
  • 2003-04-28. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex in NATURE GENETICS
  • 2003-04-14. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders in NATURE GENETICS
  • 2011-06-17. Multibudded tubules formed by COPII on artificial liposomes in SCIENTIFIC REPORTS
  • 2006-03-12. Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers in NATURE CELL BIOLOGY
  • 2009-02-22. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization in NATURE CELL BIOLOGY
  • 1997-09-04. ER-to-Golgi transport visualized in living cells in NATURE
  • 2011-04-10. TFG-1 function in protein secretion and oncogenesis in NATURE CELL BIOLOGY
  • 2006-01. Structure of the Sec13/31 COPII coat cage in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2390

    DOI

    http://dx.doi.org/10.1038/ncb2390

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042603741

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22193160


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