VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09-11

AUTHORS

Tuomas Tammela, Georgia Zarkada, Harri Nurmi, Lars Jakobsson, Krista Heinolainen, Denis Tvorogov, Wei Zheng, Claudio A. Franco, Aino Murtomäki, Evelyn Aranda, Naoyuki Miura, Seppo Ylä-Herttuala, Marcus Fruttiger, Taija Mäkinen, Anne Eichmann, Jeffrey W. Pollard, Holger Gerhardt, Kari Alitalo

ABSTRACT

Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2+/−;Vegfr3+/− compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts. More... »

PAGES

1202-1213

References to SciGraph publications

  • 2008-04-07. A brief introduction to FOXOlogy in ONCOGENE
  • 1996-04. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene in NATURE
  • 2003-11-23. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins in NATURE IMMUNOLOGY
  • 2010-05-05. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis in NATURE
  • 2003-05-12. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells in NATURE MEDICINE
  • 2007-01-28. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis in NATURE
  • 1995-07. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice in NATURE
  • 2007-01-28. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries in NATURE
  • 2008-06-25. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation in NATURE
  • 2010-08-10. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis in CELL RESEARCH
  • 1999-01. Generalized lacZ expression with the ROSA26 Cre reporter strain in NATURE GENETICS
  • 2010-05-27. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis in NATURE
  • 1996-04. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele in NATURE
  • 2006-06-21. Endothelial tubes assemble from intracellular vacuoles in vivo in NATURE
  • 2004-08-22. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis in NATURE MEDICINE
  • 2010-09-26. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting in NATURE CELL BIOLOGY
  • 2006-02-05. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain in NATURE NEUROSCIENCE
  • Journal

    TITLE

    Nature Cell Biology

    ISSUE

    10

    VOLUME

    13

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2331

    DOI

    http://dx.doi.org/10.1038/ncb2331

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035381331

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21909098


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Forkhead Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Human Umbilical Vein Endothelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrophages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Physiologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylinositol 3-Kinase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Interference", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Notch", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinal Vessels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rhombencephalon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transduction, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transfection", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor D", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor Receptor-3", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tammela", 
            "givenName": "Tuomas", 
            "id": "sg:person.0776201022.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776201022.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zarkada", 
            "givenName": "Georgia", 
            "id": "sg:person.01100325041.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100325041.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nurmi", 
            "givenName": "Harri", 
            "id": "sg:person.01164561424.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164561424.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles V\u00e4g 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK (T.M.)", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Vascular Biology Laboratory, London Research Institute\u2014Cancer Research UK, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK", 
                "Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles V\u00e4g 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK (T.M.)"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jakobsson", 
            "givenName": "Lars", 
            "id": "sg:person.01241764637.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241764637.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heinolainen", 
            "givenName": "Krista", 
            "id": "sg:person.01301010024.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301010024.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tvorogov", 
            "givenName": "Denis", 
            "id": "sg:person.0703432401.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703432401.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Wei", 
            "id": "sg:person.01101404354.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101404354.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vascular Biology Laboratory, London Research Institute\u2014Cancer Research UK, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK", 
              "id": "http://www.grid.ac/institutes/grid.11485.39", 
              "name": [
                "Vascular Biology Laboratory, London Research Institute\u2014Cancer Research UK, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franco", 
            "givenName": "Claudio A.", 
            "id": "sg:person.01151176565.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151176565.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murtom\u00e4ki", 
            "givenName": "Aino", 
            "id": "sg:person.01337363273.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337363273.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA", 
              "id": "http://www.grid.ac/institutes/grid.251993.5", 
              "name": [
                "Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aranda", 
            "givenName": "Evelyn", 
            "id": "sg:person.01304650072.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304650072.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, Hamamatsu University School of Medicine, 431-3192 Hamamatsu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.505613.4", 
              "name": [
                "Department of Biochemistry, Hamamatsu University School of Medicine, 431-3192 Hamamatsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miura", 
            "givenName": "Naoyuki", 
            "id": "sg:person.013736402411.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013736402411.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "A. I. Virtanen Institute and Department of Medicine, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland", 
              "id": "http://www.grid.ac/institutes/grid.9668.1", 
              "name": [
                "A. I. Virtanen Institute and Department of Medicine, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yl\u00e4-Herttuala", 
            "givenName": "Seppo", 
            "id": "sg:person.0657164060.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657164060.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Ophthalmology, University College London, London EC1V 9EL, UK", 
              "id": "http://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Institute of Ophthalmology, University College London, London EC1V 9EL, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fruttiger", 
            "givenName": "Marcus", 
            "id": "sg:person.011133171147.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011133171147.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles V\u00e4g 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK (T.M.)", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
                "Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles V\u00e4g 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK (T.M.)"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e4kinen", 
            "givenName": "Taija", 
            "id": "sg:person.01122760613.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122760613.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U833, Coll\u00e8ge de France, 11 Place Marcelin Berthelot, 75005 Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.410533.0", 
              "name": [
                "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U833, Coll\u00e8ge de France, 11 Place Marcelin Berthelot, 75005 Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eichmann", 
            "givenName": "Anne", 
            "id": "sg:person.01132655726.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132655726.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA", 
              "id": "http://www.grid.ac/institutes/grid.251993.5", 
              "name": [
                "Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pollard", 
            "givenName": "Jeffrey W.", 
            "id": "sg:person.01175573000.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175573000.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vascular Patterning Laboratory, Vesalius Research Center, VIB, Campus Gasthuisberg, B-3000 Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.11486.3a", 
              "name": [
                "Vascular Biology Laboratory, London Research Institute\u2014Cancer Research UK, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK", 
                "Vascular Patterning Laboratory, Vesalius Research Center, VIB, Campus Gasthuisberg, B-3000 Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerhardt", 
            "givenName": "Holger", 
            "id": "sg:person.0754535466.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754535466.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alitalo", 
            "givenName": "Kari", 
            "id": "sg:person.01334454760.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334454760.06"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nn1646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016299404", 
              "https://doi.org/10.1038/nn1646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044226303", 
              "https://doi.org/10.1038/nm871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839891", 
              "https://doi.org/10.1038/5007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007540186", 
              "https://doi.org/10.1038/nature07083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041374258", 
              "https://doi.org/10.1038/nature08995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020804427", 
              "https://doi.org/10.1038/nature04923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046436876", 
              "https://doi.org/10.1038/cr.2010.116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380439a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004384986", 
              "https://doi.org/10.1038/380439a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380435a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034005847", 
              "https://doi.org/10.1038/380435a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002905521", 
              "https://doi.org/10.1038/nm1094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045720229", 
              "https://doi.org/10.1038/nature05577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017225679", 
              "https://doi.org/10.1038/ncb2103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009360999", 
              "https://doi.org/10.1038/nature05571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016199935", 
              "https://doi.org/10.1038/ni1013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376062a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021421211", 
              "https://doi.org/10.1038/376062a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028883419", 
              "https://doi.org/10.1038/nature09002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010862860", 
              "https://doi.org/10.1038/onc.2008.29"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-09-11", 
        "datePublishedReg": "2011-09-11", 
        "description": "Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2+/\u2212;Vegfr3+/\u2212 compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ncb2331", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2479665", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2770832", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3790126", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5145164", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2752130", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021344", 
            "issn": [
              "1465-7392", 
              "1476-4679"
            ], 
            "name": "Nature Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "keywords": [
          "tip cells", 
          "Notch signaling", 
          "angiogenic sprouting", 
          "VEGFR-3", 
          "target gene expression", 
          "levels of Notch", 
          "stalk cells", 
          "growth factor receptor", 
          "endothelial cells", 
          "gene expression", 
          "Notch ligands", 
          "ligand VEGF", 
          "vessel sprouts", 
          "new blood vessels", 
          "phenotypic conversion", 
          "macrophage-derived VEGF", 
          "homozygous loss", 
          "factor receptor", 
          "vascular branching", 
          "endothelial deletion", 
          "fusion site", 
          "vascular endothelial growth factor receptor", 
          "fusion point", 
          "endothelial growth factor receptor", 
          "signaling", 
          "heterozygous mice", 
          "VEGFR3", 
          "cells", 
          "compound heterozygosity", 
          "branch points", 
          "angiogenesis", 
          "inefficient angiogenesis", 
          "vessel branch points", 
          "Notch", 
          "FOXC2", 
          "sprouting", 
          "heterozygosity", 
          "branching", 
          "regulator", 
          "deletion", 
          "VEGF", 
          "expression", 
          "receptors", 
          "sprouts", 
          "blood vessels", 
          "growth", 
          "macrophages", 
          "sites", 
          "mice", 
          "ligands", 
          "conversion", 
          "antibodies", 
          "loss", 
          "levels", 
          "tip", 
          "results", 
          "vessels", 
          "specification", 
          "point", 
          "modalities"
        ], 
        "name": "VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling", 
        "pagination": "1202-1213", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035381331"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncb2331"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21909098"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncb2331", 
          "https://app.dimensions.ai/details/publication/pub.1035381331"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_549.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ncb2331"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb2331'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb2331'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb2331'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb2331'


     

    This table displays all metadata directly associated to this object as RDF triples.

    457 TRIPLES      21 PREDICATES      130 URIs      105 LITERALS      35 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncb2331 schema:about N016dbe2991d149599597211c6e00773b
    2 N09ab1d3c41fc4feb92295b3aded93e9c
    3 N0ff0fb6237884ef9bfd4a57b8b88c12b
    4 N160c10197db74bbcaf9c4938bfe71f8f
    5 N1b2b075e46314dcf8ce51ee2827c7c80
    6 N25a6973ade524d019435ed057ef585ef
    7 N2d0750fbcd01414f8a9e5e05c93e764b
    8 N31afa4c01f624adda5ea4f8006c6689b
    9 N36ab3dc11817465ca716854816b32238
    10 N61064cea01e74a4da7dfc1e4aed0086d
    11 N61991a57956949e0a10bb793a9375f53
    12 N66e73a245a7b4eb0a4dcc5555f17916a
    13 N70571d3ae3b44a64b0bfbaf050f3a9bf
    14 N74313af562294deebaafd4cd58fbbefb
    15 N825e42a4d2cf4988b56c3b51491ba382
    16 N8311a43dee0442208fda1eef7a4759a9
    17 N968e5ef32cb34ca3a557273394a2b43f
    18 N9a49e519056947f7ae3c8c3c356db56f
    19 Na038ffb591df479188de1abe296fbfe5
    20 Na0837157f46e4951bfc75f6fe238fc6a
    21 Na374c9036fdb43bcb514de90e70817e7
    22 Nb5ad2e64b87f41959620cf3fb24060a7
    23 Nb5eda1480386401f8f260dbe057d3cff
    24 Nd43c09b36bf347b9a7cf8f975537ce18
    25 Ne8961e7880494535af480967a26a458c
    26 Ne983fd13b0394d42bdb3ac3599f439bc
    27 Nff27331d358e4cfda90d2dd053f55a5b
    28 Nff532208873c4f00be7161eefd25134c
    29 anzsrc-for:06
    30 anzsrc-for:0601
    31 schema:author Na206c1e13261471c87f1e2a8661703be
    32 schema:citation sg:pub.10.1038/376062a0
    33 sg:pub.10.1038/380435a0
    34 sg:pub.10.1038/380439a0
    35 sg:pub.10.1038/5007
    36 sg:pub.10.1038/cr.2010.116
    37 sg:pub.10.1038/nature04923
    38 sg:pub.10.1038/nature05571
    39 sg:pub.10.1038/nature05577
    40 sg:pub.10.1038/nature07083
    41 sg:pub.10.1038/nature08995
    42 sg:pub.10.1038/nature09002
    43 sg:pub.10.1038/ncb2103
    44 sg:pub.10.1038/ni1013
    45 sg:pub.10.1038/nm1094
    46 sg:pub.10.1038/nm871
    47 sg:pub.10.1038/nn1646
    48 sg:pub.10.1038/onc.2008.29
    49 schema:datePublished 2011-09-11
    50 schema:datePublishedReg 2011-09-11
    51 schema:description Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2+/−;Vegfr3+/− compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.
    52 schema:genre article
    53 schema:isAccessibleForFree true
    54 schema:isPartOf N1e3a12de49bd42b1bf4ea65145e981c1
    55 Nf1ea6f13049d4e57850972f715d64c66
    56 sg:journal.1021344
    57 schema:keywords FOXC2
    58 Notch
    59 Notch ligands
    60 Notch signaling
    61 VEGF
    62 VEGFR-3
    63 VEGFR3
    64 angiogenesis
    65 angiogenic sprouting
    66 antibodies
    67 blood vessels
    68 branch points
    69 branching
    70 cells
    71 compound heterozygosity
    72 conversion
    73 deletion
    74 endothelial cells
    75 endothelial deletion
    76 endothelial growth factor receptor
    77 expression
    78 factor receptor
    79 fusion point
    80 fusion site
    81 gene expression
    82 growth
    83 growth factor receptor
    84 heterozygosity
    85 heterozygous mice
    86 homozygous loss
    87 inefficient angiogenesis
    88 levels
    89 levels of Notch
    90 ligand VEGF
    91 ligands
    92 loss
    93 macrophage-derived VEGF
    94 macrophages
    95 mice
    96 modalities
    97 new blood vessels
    98 phenotypic conversion
    99 point
    100 receptors
    101 regulator
    102 results
    103 signaling
    104 sites
    105 specification
    106 sprouting
    107 sprouts
    108 stalk cells
    109 target gene expression
    110 tip
    111 tip cells
    112 vascular branching
    113 vascular endothelial growth factor receptor
    114 vessel branch points
    115 vessel sprouts
    116 vessels
    117 schema:name VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
    118 schema:pagination 1202-1213
    119 schema:productId N0ecd901c33334caebc4b4dd3c0ce8c44
    120 N5986e7938dc644ee956dbc4857474cfa
    121 Ne19fe979d2aa481b95cd96f7b6405da6
    122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035381331
    123 https://doi.org/10.1038/ncb2331
    124 schema:sdDatePublished 2022-10-01T06:37
    125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    126 schema:sdPublisher N73a90862f9e14e9e91e59cf790dc7c04
    127 schema:url https://doi.org/10.1038/ncb2331
    128 sgo:license sg:explorer/license/
    129 sgo:sdDataset articles
    130 rdf:type schema:ScholarlyArticle
    131 N016dbe2991d149599597211c6e00773b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Cell Line, Tumor
    133 rdf:type schema:DefinedTerm
    134 N05f02f5cbc5d461782ee304ba284b03d rdf:first sg:person.01151176565.13
    135 rdf:rest N3a8bdaf011dc4999b6b73323803aca73
    136 N06bb886629c44bbe83a5ed2e1ebcd1a1 rdf:first sg:person.01304650072.25
    137 rdf:rest Nc551cc2ae0904462aa639b6e582e6218
    138 N09ab1d3c41fc4feb92295b3aded93e9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Vascular Endothelial Growth Factor C
    140 rdf:type schema:DefinedTerm
    141 N0ecd901c33334caebc4b4dd3c0ce8c44 schema:name dimensions_id
    142 schema:value pub.1035381331
    143 rdf:type schema:PropertyValue
    144 N0ff0fb6237884ef9bfd4a57b8b88c12b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Protein Kinase Inhibitors
    146 rdf:type schema:DefinedTerm
    147 N160c10197db74bbcaf9c4938bfe71f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Signal Transduction
    149 rdf:type schema:DefinedTerm
    150 N1b2b075e46314dcf8ce51ee2827c7c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Humans
    152 rdf:type schema:DefinedTerm
    153 N1e3a12de49bd42b1bf4ea65145e981c1 schema:volumeNumber 13
    154 rdf:type schema:PublicationVolume
    155 N25a6973ade524d019435ed057ef585ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Neovascularization, Physiologic
    157 rdf:type schema:DefinedTerm
    158 N2d0750fbcd01414f8a9e5e05c93e764b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Phosphatidylinositol 3-Kinase
    160 rdf:type schema:DefinedTerm
    161 N31afa4c01f624adda5ea4f8006c6689b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Vascular Endothelial Growth Factor A
    163 rdf:type schema:DefinedTerm
    164 N36ab3dc11817465ca716854816b32238 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Antibodies
    166 rdf:type schema:DefinedTerm
    167 N3a8bdaf011dc4999b6b73323803aca73 rdf:first sg:person.01337363273.47
    168 rdf:rest N06bb886629c44bbe83a5ed2e1ebcd1a1
    169 N3e8ffeb4a647415c8556988fd4ae4add rdf:first sg:person.01100325041.21
    170 rdf:rest Nd8742319bfe54559ae90b76ee96fcd89
    171 N4ed9ce6fb9884b228f86516a65c4d7ba rdf:first sg:person.0754535466.06
    172 rdf:rest N6c7fcf93344a4abbb2a9f1c648b84dbb
    173 N57488a01a30844589fb0635b794bb9e4 rdf:first sg:person.0657164060.26
    174 rdf:rest Ndb812bc5435040a19379cb91e3f31b20
    175 N5986e7938dc644ee956dbc4857474cfa schema:name doi
    176 schema:value 10.1038/ncb2331
    177 rdf:type schema:PropertyValue
    178 N61064cea01e74a4da7dfc1e4aed0086d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Animals
    180 rdf:type schema:DefinedTerm
    181 N61991a57956949e0a10bb793a9375f53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Forkhead Transcription Factors
    183 rdf:type schema:DefinedTerm
    184 N62a92a913c6744a1ad736f051a0a0e5c rdf:first sg:person.01241764637.35
    185 rdf:rest Ne6c89fc4eb7e4b22910a5e3159f21818
    186 N66e73a245a7b4eb0a4dcc5555f17916a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Neovascularization, Pathologic
    188 rdf:type schema:DefinedTerm
    189 N6c68df1c5ff942dd9bc8ed131acacc31 rdf:first sg:person.01101404354.05
    190 rdf:rest N05f02f5cbc5d461782ee304ba284b03d
    191 N6c7fcf93344a4abbb2a9f1c648b84dbb rdf:first sg:person.01334454760.06
    192 rdf:rest rdf:nil
    193 N70571d3ae3b44a64b0bfbaf050f3a9bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Endothelial Cells
    195 rdf:type schema:DefinedTerm
    196 N73a90862f9e14e9e91e59cf790dc7c04 schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 N74313af562294deebaafd4cd58fbbefb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Vascular Endothelial Growth Factor Receptor-3
    200 rdf:type schema:DefinedTerm
    201 N825e42a4d2cf4988b56c3b51491ba382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Receptors, Notch
    203 rdf:type schema:DefinedTerm
    204 N8311a43dee0442208fda1eef7a4759a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Mice
    206 rdf:type schema:DefinedTerm
    207 N968e5ef32cb34ca3a557273394a2b43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Vascular Endothelial Growth Factor B
    209 rdf:type schema:DefinedTerm
    210 N9a49e519056947f7ae3c8c3c356db56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Time Factors
    212 rdf:type schema:DefinedTerm
    213 Na038ffb591df479188de1abe296fbfe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Macrophages
    215 rdf:type schema:DefinedTerm
    216 Na0837157f46e4951bfc75f6fe238fc6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Transduction, Genetic
    218 rdf:type schema:DefinedTerm
    219 Na206c1e13261471c87f1e2a8661703be rdf:first sg:person.0776201022.54
    220 rdf:rest N3e8ffeb4a647415c8556988fd4ae4add
    221 Na374c9036fdb43bcb514de90e70817e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Gene Expression Regulation
    223 rdf:type schema:DefinedTerm
    224 Nb5ad2e64b87f41959620cf3fb24060a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Human Umbilical Vein Endothelial Cells
    226 rdf:type schema:DefinedTerm
    227 Nb5eda1480386401f8f260dbe057d3cff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Mice, Knockout
    229 rdf:type schema:DefinedTerm
    230 Nc551cc2ae0904462aa639b6e582e6218 rdf:first sg:person.013736402411.13
    231 rdf:rest N57488a01a30844589fb0635b794bb9e4
    232 Nc91a2f186e2f49e2a33e1e8537b26768 rdf:first sg:person.0703432401.32
    233 rdf:rest N6c68df1c5ff942dd9bc8ed131acacc31
    234 Nd43c09b36bf347b9a7cf8f975537ce18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Vascular Endothelial Growth Factor D
    236 rdf:type schema:DefinedTerm
    237 Nd8742319bfe54559ae90b76ee96fcd89 rdf:first sg:person.01164561424.34
    238 rdf:rest N62a92a913c6744a1ad736f051a0a0e5c
    239 Ndb812bc5435040a19379cb91e3f31b20 rdf:first sg:person.011133171147.12
    240 rdf:rest Ne18fb1bb46e94483aed8820a148c7abb
    241 Ndcb60d911ebd4d37983250a033fa8ff8 rdf:first sg:person.01175573000.03
    242 rdf:rest N4ed9ce6fb9884b228f86516a65c4d7ba
    243 Ne18fb1bb46e94483aed8820a148c7abb rdf:first sg:person.01122760613.30
    244 rdf:rest Ne6b3c95fe568410698bd1f4c276bbe10
    245 Ne19fe979d2aa481b95cd96f7b6405da6 schema:name pubmed_id
    246 schema:value 21909098
    247 rdf:type schema:PropertyValue
    248 Ne6b3c95fe568410698bd1f4c276bbe10 rdf:first sg:person.01132655726.95
    249 rdf:rest Ndcb60d911ebd4d37983250a033fa8ff8
    250 Ne6c89fc4eb7e4b22910a5e3159f21818 rdf:first sg:person.01301010024.51
    251 rdf:rest Nc91a2f186e2f49e2a33e1e8537b26768
    252 Ne8961e7880494535af480967a26a458c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name RNA Interference
    254 rdf:type schema:DefinedTerm
    255 Ne983fd13b0394d42bdb3ac3599f439bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Retinal Vessels
    257 rdf:type schema:DefinedTerm
    258 Nf1ea6f13049d4e57850972f715d64c66 schema:issueNumber 10
    259 rdf:type schema:PublicationIssue
    260 Nff27331d358e4cfda90d2dd053f55a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Rhombencephalon
    262 rdf:type schema:DefinedTerm
    263 Nff532208873c4f00be7161eefd25134c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Transfection
    265 rdf:type schema:DefinedTerm
    266 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    267 schema:name Biological Sciences
    268 rdf:type schema:DefinedTerm
    269 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    270 schema:name Biochemistry and Cell Biology
    271 rdf:type schema:DefinedTerm
    272 sg:grant.2479665 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2331
    273 rdf:type schema:MonetaryGrant
    274 sg:grant.2752130 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2331
    275 rdf:type schema:MonetaryGrant
    276 sg:grant.2770832 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2331
    277 rdf:type schema:MonetaryGrant
    278 sg:grant.3790126 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2331
    279 rdf:type schema:MonetaryGrant
    280 sg:grant.5145164 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2331
    281 rdf:type schema:MonetaryGrant
    282 sg:journal.1021344 schema:issn 1465-7392
    283 1476-4679
    284 schema:name Nature Cell Biology
    285 schema:publisher Springer Nature
    286 rdf:type schema:Periodical
    287 sg:person.01100325041.21 schema:affiliation grid-institutes:grid.15485.3d
    288 schema:familyName Zarkada
    289 schema:givenName Georgia
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100325041.21
    291 rdf:type schema:Person
    292 sg:person.01101404354.05 schema:affiliation grid-institutes:grid.15485.3d
    293 schema:familyName Zheng
    294 schema:givenName Wei
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101404354.05
    296 rdf:type schema:Person
    297 sg:person.011133171147.12 schema:affiliation grid-institutes:grid.83440.3b
    298 schema:familyName Fruttiger
    299 schema:givenName Marcus
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011133171147.12
    301 rdf:type schema:Person
    302 sg:person.01122760613.30 schema:affiliation grid-institutes:grid.4714.6
    303 schema:familyName Mäkinen
    304 schema:givenName Taija
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122760613.30
    306 rdf:type schema:Person
    307 sg:person.01132655726.95 schema:affiliation grid-institutes:grid.410533.0
    308 schema:familyName Eichmann
    309 schema:givenName Anne
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132655726.95
    311 rdf:type schema:Person
    312 sg:person.01151176565.13 schema:affiliation grid-institutes:grid.11485.39
    313 schema:familyName Franco
    314 schema:givenName Claudio A.
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151176565.13
    316 rdf:type schema:Person
    317 sg:person.01164561424.34 schema:affiliation grid-institutes:grid.15485.3d
    318 schema:familyName Nurmi
    319 schema:givenName Harri
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164561424.34
    321 rdf:type schema:Person
    322 sg:person.01175573000.03 schema:affiliation grid-institutes:grid.251993.5
    323 schema:familyName Pollard
    324 schema:givenName Jeffrey W.
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175573000.03
    326 rdf:type schema:Person
    327 sg:person.01241764637.35 schema:affiliation grid-institutes:grid.4714.6
    328 schema:familyName Jakobsson
    329 schema:givenName Lars
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241764637.35
    331 rdf:type schema:Person
    332 sg:person.01301010024.51 schema:affiliation grid-institutes:grid.15485.3d
    333 schema:familyName Heinolainen
    334 schema:givenName Krista
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301010024.51
    336 rdf:type schema:Person
    337 sg:person.01304650072.25 schema:affiliation grid-institutes:grid.251993.5
    338 schema:familyName Aranda
    339 schema:givenName Evelyn
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304650072.25
    341 rdf:type schema:Person
    342 sg:person.01334454760.06 schema:affiliation grid-institutes:grid.15485.3d
    343 schema:familyName Alitalo
    344 schema:givenName Kari
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334454760.06
    346 rdf:type schema:Person
    347 sg:person.01337363273.47 schema:affiliation grid-institutes:grid.15485.3d
    348 schema:familyName Murtomäki
    349 schema:givenName Aino
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337363273.47
    351 rdf:type schema:Person
    352 sg:person.013736402411.13 schema:affiliation grid-institutes:grid.505613.4
    353 schema:familyName Miura
    354 schema:givenName Naoyuki
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013736402411.13
    356 rdf:type schema:Person
    357 sg:person.0657164060.26 schema:affiliation grid-institutes:grid.9668.1
    358 schema:familyName Ylä-Herttuala
    359 schema:givenName Seppo
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657164060.26
    361 rdf:type schema:Person
    362 sg:person.0703432401.32 schema:affiliation grid-institutes:grid.15485.3d
    363 schema:familyName Tvorogov
    364 schema:givenName Denis
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703432401.32
    366 rdf:type schema:Person
    367 sg:person.0754535466.06 schema:affiliation grid-institutes:grid.11486.3a
    368 schema:familyName Gerhardt
    369 schema:givenName Holger
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754535466.06
    371 rdf:type schema:Person
    372 sg:person.0776201022.54 schema:affiliation grid-institutes:grid.15485.3d
    373 schema:familyName Tammela
    374 schema:givenName Tuomas
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776201022.54
    376 rdf:type schema:Person
    377 sg:pub.10.1038/376062a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021421211
    378 https://doi.org/10.1038/376062a0
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/380435a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034005847
    381 https://doi.org/10.1038/380435a0
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/380439a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004384986
    384 https://doi.org/10.1038/380439a0
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839891
    387 https://doi.org/10.1038/5007
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/cr.2010.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046436876
    390 https://doi.org/10.1038/cr.2010.116
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nature04923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020804427
    393 https://doi.org/10.1038/nature04923
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nature05571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009360999
    396 https://doi.org/10.1038/nature05571
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nature05577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045720229
    399 https://doi.org/10.1038/nature05577
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nature07083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007540186
    402 https://doi.org/10.1038/nature07083
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nature08995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041374258
    405 https://doi.org/10.1038/nature08995
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/nature09002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028883419
    408 https://doi.org/10.1038/nature09002
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/ncb2103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017225679
    411 https://doi.org/10.1038/ncb2103
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/ni1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016199935
    414 https://doi.org/10.1038/ni1013
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nm1094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002905521
    417 https://doi.org/10.1038/nm1094
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nm871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044226303
    420 https://doi.org/10.1038/nm871
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nn1646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016299404
    423 https://doi.org/10.1038/nn1646
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/onc.2008.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010862860
    426 https://doi.org/10.1038/onc.2008.29
    427 rdf:type schema:CreativeWork
    428 grid-institutes:grid.11485.39 schema:alternateName Vascular Biology Laboratory, London Research Institute—Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
    429 schema:name Vascular Biology Laboratory, London Research Institute—Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
    430 rdf:type schema:Organization
    431 grid-institutes:grid.11486.3a schema:alternateName Vascular Patterning Laboratory, Vesalius Research Center, VIB, Campus Gasthuisberg, B-3000 Leuven, Belgium
    432 schema:name Vascular Biology Laboratory, London Research Institute—Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
    433 Vascular Patterning Laboratory, Vesalius Research Center, VIB, Campus Gasthuisberg, B-3000 Leuven, Belgium
    434 rdf:type schema:Organization
    435 grid-institutes:grid.15485.3d schema:alternateName Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland
    436 schema:name Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland
    437 rdf:type schema:Organization
    438 grid-institutes:grid.251993.5 schema:alternateName Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    439 schema:name Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    440 rdf:type schema:Organization
    441 grid-institutes:grid.410533.0 schema:alternateName Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France
    442 schema:name Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France
    443 rdf:type schema:Organization
    444 grid-institutes:grid.4714.6 schema:alternateName Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK (T.M.)
    445 schema:name Present addresses: Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, SE171 77 Stockholm, Sweden (L.K.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK (T.M.)
    446 Research Programs Unit and Department of Pathology, Molecular/Cancer Biology Laboratory, Institute for Molecular Medicine Finland, Haartman Institute, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland
    447 Vascular Biology Laboratory, London Research Institute—Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
    448 rdf:type schema:Organization
    449 grid-institutes:grid.505613.4 schema:alternateName Department of Biochemistry, Hamamatsu University School of Medicine, 431-3192 Hamamatsu, Japan
    450 schema:name Department of Biochemistry, Hamamatsu University School of Medicine, 431-3192 Hamamatsu, Japan
    451 rdf:type schema:Organization
    452 grid-institutes:grid.83440.3b schema:alternateName Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    453 schema:name Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    454 rdf:type schema:Organization
    455 grid-institutes:grid.9668.1 schema:alternateName A. I. Virtanen Institute and Department of Medicine, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    456 schema:name A. I. Virtanen Institute and Department of Medicine, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    457 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...