Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10

AUTHORS

Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick, Elizabeth A. Jonas

ABSTRACT

Anti-apoptotic Bcl2 family proteins such as Bcl-x(L) protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal function. We find in hippocampal neurons that Bcl-x(L) enhances the efficiency of energy metabolism. Our evidence indicates that Bcl-x(L)interacts directly with the β-subunit of the F(1)F(O) ATP synthase, decreasing an ion leak within the F(1)F(O) ATPase complex and thereby increasing net transport of H(+) by F(1)F(O) during F(1)F(O) ATPase activity. By patch clamping submitochondrial vesicles enriched in F(1)F(O) ATP synthase complexes, we find that, in the presence of ATP, pharmacological or genetic inhibition of Bcl-x(L) activity increases the membrane leak conductance. In addition, recombinant Bcl-x(L) protein directly increases the level of ATPase activity of purified synthase complexes, and inhibition of endogenous Bcl-x(L) decreases the level of F(1)F(O) enzymatic activity. Our findings indicate that increased mitochondrial efficiency contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons. More... »

PAGES

1224

References to SciGraph publications

  • 2005-06. An inhibitor of Bcl-2 family proteins induces regression of solid tumours in NATURE
  • 2008-12. Mimicking the BH3 domain to kill cancer cells in ONCOGENE
  • 1996-02. Bax-independent inhibition of apoptosis by Bcl-XL in NATURE
  • 2005-11. Mitochondrial uncoupling proteins in the cns: in support of function and survival in NATURE REVIEWS NEUROSCIENCE
  • 2002-11. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis in ONCOGENE
  • 2006-09. Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development in NATURE NEUROSCIENCE
  • 2009-04. Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2006-12. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies in NATURE CELL BIOLOGY
  • 2004-08. Mitochondrial Uncoupling as a Therapeutic Target Following Neuronal Injury in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2009-04. MitoKATP activity in healthy and ischemic hearts in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2006-12. Upgrading the BCL-2 Network in NATURE CELL BIOLOGY
  • 1997-08. Hexokinase Binding to Mitochondria: A Basis for Proliferative Energy Metabolism in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2008-10. Uncoupling protein 1: a short-circuit in the chemiosmotic process in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2008-01. The BCL-2 protein family: opposing activities that mediate cell death in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1990-11. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death in NATURE
  • 2002-02. Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system in CELL DEATH & DIFFERENTIATION
  • 2007-12. Efficient transfection of DNA or shRNA vectors into neurons using magnetofection in NATURE PROTOCOLS
  • 2000-07. Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2330

    DOI

    http://dx.doi.org/10.1038/ncb2330

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042317501

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21926988


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