Actin dynamics counteract membrane tension during clathrin-mediated endocytosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

Steeve Boulant, Comert Kural, Jean-Christophe Zeeh, Florent Ubelmann, Tomas Kirchhausen

ABSTRACT

Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of actin polymerization on both dorsal and ventral surfaces of non-polarized mammalian cells, and also on basolateral surfaces of polarized cells. Actin engagement is necessary, however, to complete membrane deformation into a coated pit on apical surfaces of polarized cells and, more generally, on the surface of any cell in which the plasma membrane is under tension from osmotic swelling or mechanical stretching. We use these observations to alter actin dependence experimentally and show that resistance of the membrane to propagation of the clathrin lattice determines the distinction between 'actin dependent and 'actin independent'. We also find that light-chain-bound Hip1R mediates actin engagement. These data thus provide a unifying explanation for the role of actin dynamics in coated-pit budding. More... »

PAGES

1124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb2307

DOI

http://dx.doi.org/10.1038/ncb2307

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046485018

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21841790


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