Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Elaine M. Pinheiro, Zhigang Xie, Amy L. Norovich, Marina Vidaki, Li-Huei Tsai, Frank B. Gertler

ABSTRACT

During corticogenesis, pyramidal neurons (∼80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia, and then migrate to their proper position within the cortex. As pyramidal neurons migrate radially, they remain attached to their glial substrate as they pass through the subventricular and intermediate zones, regions rich in tangentially migrating interneurons and axon fibre tracts. We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode. More... »

PAGES

989

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb2292

DOI

http://dx.doi.org/10.1038/ncb2292

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045207330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21785421


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Neurological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyramidal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Response Factor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinheiro", 
        "givenName": "Elaine M.", 
        "id": "sg:person.01053005332.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053005332.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University School of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.475010.7", 
          "name": [
            "Department of Neurosurgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Zhigang", 
        "id": "sg:person.01212411675.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212411675.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Norovich", 
        "givenName": "Amy L.", 
        "id": "sg:person.0754507066.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754507066.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidaki", 
        "givenName": "Marina", 
        "id": "sg:person.01060244434.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060244434.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA", 
            "Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "Li-Huei", 
        "id": "sg:person.01120762357.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120762357.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gertler", 
        "givenName": "Frank B.", 
        "id": "sg:person.0755724733.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755724733.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.devcel.2004.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007480468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200203126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007644247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010462166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2010.03.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011908896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013644611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.02-05-0068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016610873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.08.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018043521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.08.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018043521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(80)90352-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021332533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(80)90352-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021332533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00278-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021812734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/13.6.541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025889677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2006.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027458396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2007.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028925735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028972265", 
          "https://doi.org/10.1038/nature06063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5728-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029011925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030395434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2004.07.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033151314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.26.041002.131058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036505655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2008.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038022426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2004.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038710329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040341833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040667470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.1020110107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041719712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.1020110107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041719712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047393206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.8.4640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047966811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049460705", 
          "https://doi.org/10.1038/nn1666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.03.083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051983127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00267823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052611363", 
          "https://doi.org/10.1007/bf00267823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00267823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052611363", 
          "https://doi.org/10.1007/bf00267823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1141084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062455931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074578271", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-08", 
    "datePublishedReg": "2011-08-01", 
    "description": "During corticogenesis, pyramidal neurons (\u223c80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia, and then migrate to their proper position within the cortex. As pyramidal neurons migrate radially, they remain attached to their glial substrate as they pass through the subventricular and intermediate zones, regions rich in tangentially migrating interneurons and axon fibre tracts. We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb2292", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2382287", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2518039", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons", 
    "pagination": "989", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d7565af90cfe88c9e07362e820f6e06131028bfdacf9c39fd3c3fa4a2c446164"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21785421"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb2292"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045207330"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb2292", 
      "https://app.dimensions.ai/details/publication/pub.1045207330"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncb2292"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb2292'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb2292'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb2292'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb2292'


 

This table displays all metadata directly associated to this object as RDF triples.

256 TRIPLES      21 PREDICATES      71 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb2292 schema:about N0c20f8ed0d454cff8630d4c8b35f2171
2 N122e329b43084504b532319fa1e00cfe
3 N3579b26c16d1418eb498eb796c83495e
4 N3ce999dbf8bc4de0a248014f4b8064a6
5 N3f9709cd8fad4a4dace14ea952fae08f
6 N44624e64e73748b7b556f3d068a5a6d2
7 N6fea67b397d24ae2abbcd5f850b4e50c
8 N8ae3e276a4ab497584a92171efa78336
9 N9a0b8c571efa4dd58a911d431bf6d4df
10 Na8b3cd03897a414caa8853d489cbc13e
11 Nb9f349e37a5c4e7198eb2d384c8444ca
12 Ndc78125432854d208f7e48de7a3296f4
13 Ne1033beadc9a4d7580c8416b36334c45
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author Nf53952073f0549eb8dd5a2576ce68eb7
17 schema:citation sg:pub.10.1007/bf00267823
18 sg:pub.10.1038/nature06063
19 sg:pub.10.1038/nn1666
20 https://app.dimensions.ai/details/publication/pub.1074578271
21 https://doi.org/10.1002/dvg.1020110107
22 https://doi.org/10.1016/0006-8993(80)90352-2
23 https://doi.org/10.1016/j.cell.2006.12.021
24 https://doi.org/10.1016/j.cub.2006.03.025
25 https://doi.org/10.1016/j.cub.2006.03.083
26 https://doi.org/10.1016/j.cub.2006.08.035
27 https://doi.org/10.1016/j.cub.2010.03.048
28 https://doi.org/10.1016/j.devcel.2004.07.021
29 https://doi.org/10.1016/j.devcel.2004.07.024
30 https://doi.org/10.1016/j.devcel.2008.09.020
31 https://doi.org/10.1016/j.neuron.2005.08.032
32 https://doi.org/10.1016/j.neuron.2007.08.026
33 https://doi.org/10.1016/j.neuron.2010.12.005
34 https://doi.org/10.1016/j.neuron.2010.12.006
35 https://doi.org/10.1016/j.tcb.2006.09.008
36 https://doi.org/10.1016/j.tins.2004.05.001
37 https://doi.org/10.1016/s0092-8674(03)00278-2
38 https://doi.org/10.1083/jcb.200203126
39 https://doi.org/10.1091/mbc.02-05-0068
40 https://doi.org/10.1093/cercor/13.6.541
41 https://doi.org/10.1126/science.1141084
42 https://doi.org/10.1128/mcb.13.8.4640
43 https://doi.org/10.1146/annurev.neuro.26.041002.131058
44 https://doi.org/10.1371/journal.pone.0000794
45 https://doi.org/10.1523/jneurosci.5728-09.2010
46 schema:datePublished 2011-08
47 schema:datePublishedReg 2011-08-01
48 schema:description During corticogenesis, pyramidal neurons (∼80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia, and then migrate to their proper position within the cortex. As pyramidal neurons migrate radially, they remain attached to their glial substrate as they pass through the subventricular and intermediate zones, regions rich in tangentially migrating interneurons and axon fibre tracts. We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N42ccb17e9a4d4a619a3c16bda9692c73
53 N663c9aee57684662a0d1bb4e41328e9c
54 sg:journal.1021344
55 schema:name Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons
56 schema:pagination 989
57 schema:productId N6e2b7f6c649049fcba65d458d5f33ec3
58 Na7534b0bbfb14046956626a60bf160e1
59 Nb47ccbe8edf042aca4b66206ee0cf3a7
60 Nbbf335103b3549b9bb64b1485cd851d0
61 Nfcd598f71c9f4ea78fadf5e857b973d9
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045207330
63 https://doi.org/10.1038/ncb2292
64 schema:sdDatePublished 2019-04-10T21:26
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N30dcafdc9cdd402ab594098121c3bb66
67 schema:url https://www.nature.com/articles/ncb2292
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N0c20f8ed0d454cff8630d4c8b35f2171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Pregnancy
73 rdf:type schema:DefinedTerm
74 N122e329b43084504b532319fa1e00cfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Nerve Tissue Proteins
76 rdf:type schema:DefinedTerm
77 N30dcafdc9cdd402ab594098121c3bb66 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N3579b26c16d1418eb498eb796c83495e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Mice
81 rdf:type schema:DefinedTerm
82 N3ce999dbf8bc4de0a248014f4b8064a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Animals
84 rdf:type schema:DefinedTerm
85 N3f9709cd8fad4a4dace14ea952fae08f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name RNA, Small Interfering
87 rdf:type schema:DefinedTerm
88 N42ccb17e9a4d4a619a3c16bda9692c73 schema:volumeNumber 13
89 rdf:type schema:PublicationVolume
90 N44624e64e73748b7b556f3d068a5a6d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Cell Movement
92 rdf:type schema:DefinedTerm
93 N4fd80c6558cd4cc6b3e6b70fe58cad7b rdf:first sg:person.01060244434.95
94 rdf:rest Nafc49bb9dd9240c98938f7558228378e
95 N602c0ac9b30f4a0c91339da564d1768f rdf:first sg:person.0754507066.79
96 rdf:rest N4fd80c6558cd4cc6b3e6b70fe58cad7b
97 N663c9aee57684662a0d1bb4e41328e9c schema:issueNumber 8
98 rdf:type schema:PublicationIssue
99 N6e2b7f6c649049fcba65d458d5f33ec3 schema:name pubmed_id
100 schema:value 21785421
101 rdf:type schema:PropertyValue
102 N6fea67b397d24ae2abbcd5f850b4e50c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Pyramidal Cells
104 rdf:type schema:DefinedTerm
105 N798c358715ae4c039b3a6d15972f3eab rdf:first sg:person.0755724733.10
106 rdf:rest rdf:nil
107 N860fe7f1da88465395f1aae6ad873a0c rdf:first sg:person.01212411675.33
108 rdf:rest N602c0ac9b30f4a0c91339da564d1768f
109 N8ae3e276a4ab497584a92171efa78336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Serum Response Factor
111 rdf:type schema:DefinedTerm
112 N9a0b8c571efa4dd58a911d431bf6d4df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Models, Neurological
114 rdf:type schema:DefinedTerm
115 Na7534b0bbfb14046956626a60bf160e1 schema:name doi
116 schema:value 10.1038/ncb2292
117 rdf:type schema:PropertyValue
118 Na8b3cd03897a414caa8853d489cbc13e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 Nafc49bb9dd9240c98938f7558228378e rdf:first sg:person.01120762357.12
122 rdf:rest N798c358715ae4c039b3a6d15972f3eab
123 Nb47ccbe8edf042aca4b66206ee0cf3a7 schema:name readcube_id
124 schema:value d7565af90cfe88c9e07362e820f6e06131028bfdacf9c39fd3c3fa4a2c446164
125 rdf:type schema:PropertyValue
126 Nb9f349e37a5c4e7198eb2d384c8444ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Neurogenesis
128 rdf:type schema:DefinedTerm
129 Nbbf335103b3549b9bb64b1485cd851d0 schema:name dimensions_id
130 schema:value pub.1045207330
131 rdf:type schema:PropertyValue
132 Ndc78125432854d208f7e48de7a3296f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Gene Knockdown Techniques
134 rdf:type schema:DefinedTerm
135 Ne1033beadc9a4d7580c8416b36334c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Base Sequence
137 rdf:type schema:DefinedTerm
138 Nf53952073f0549eb8dd5a2576ce68eb7 rdf:first sg:person.01053005332.16
139 rdf:rest N860fe7f1da88465395f1aae6ad873a0c
140 Nfcd598f71c9f4ea78fadf5e857b973d9 schema:name nlm_unique_id
141 schema:value 100890575
142 rdf:type schema:PropertyValue
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
147 schema:name Neurosciences
148 rdf:type schema:DefinedTerm
149 sg:grant.2382287 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2292
150 rdf:type schema:MonetaryGrant
151 sg:grant.2518039 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2292
152 rdf:type schema:MonetaryGrant
153 sg:journal.1021344 schema:issn 1465-7392
154 1476-4679
155 schema:name Nature Cell Biology
156 rdf:type schema:Periodical
157 sg:person.01053005332.16 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
158 schema:familyName Pinheiro
159 schema:givenName Elaine M.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053005332.16
161 rdf:type schema:Person
162 sg:person.01060244434.95 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
163 schema:familyName Vidaki
164 schema:givenName Marina
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060244434.95
166 rdf:type schema:Person
167 sg:person.01120762357.12 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
168 schema:familyName Tsai
169 schema:givenName Li-Huei
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120762357.12
171 rdf:type schema:Person
172 sg:person.01212411675.33 schema:affiliation https://www.grid.ac/institutes/grid.475010.7
173 schema:familyName Xie
174 schema:givenName Zhigang
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212411675.33
176 rdf:type schema:Person
177 sg:person.0754507066.79 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
178 schema:familyName Norovich
179 schema:givenName Amy L.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754507066.79
181 rdf:type schema:Person
182 sg:person.0755724733.10 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
183 schema:familyName Gertler
184 schema:givenName Frank B.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755724733.10
186 rdf:type schema:Person
187 sg:pub.10.1007/bf00267823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052611363
188 https://doi.org/10.1007/bf00267823
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nature06063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028972265
191 https://doi.org/10.1038/nature06063
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nn1666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049460705
194 https://doi.org/10.1038/nn1666
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1074578271 schema:CreativeWork
197 https://doi.org/10.1002/dvg.1020110107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041719712
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/0006-8993(80)90352-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021332533
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.cell.2006.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047393206
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.cub.2006.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010462166
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.cub.2006.03.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051983127
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.cub.2006.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030395434
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.cub.2010.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011908896
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.devcel.2004.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033151314
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.devcel.2004.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007480468
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.devcel.2008.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038022426
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.neuron.2005.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018043521
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.neuron.2007.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028925735
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.neuron.2010.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040341833
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.neuron.2010.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040667470
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.tcb.2006.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027458396
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.tins.2004.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038710329
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0092-8674(03)00278-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812734
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1083/jcb.200203126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007644247
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1091/mbc.02-05-0068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016610873
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/cercor/13.6.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025889677
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1126/science.1141084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455931
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1128/mcb.13.8.4640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047966811
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1146/annurev.neuro.26.041002.131058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036505655
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.pone.0000794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013644611
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1523/jneurosci.5728-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029011925
246 rdf:type schema:CreativeWork
247 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
248 schema:name Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
251 schema:name Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, USA
252 Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.475010.7 schema:alternateName Boston University School of Medicine
255 schema:name Department of Neurosurgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
256 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...