53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Claudia Lukas, Velibor Savic, Simon Bekker-Jensen, Carsten Doil, Beate Neumann, Ronni Sølvhøj Pedersen, Merete Grøfte, Kok Lung Chan, Ian David Hickson, Jiri Bartek, Jiri Lukas

ABSTRACT

Completion of genome duplication is challenged by structural and topological barriers that impede progression of replication forks. Although this can seriously undermine genome integrity, the fate of DNA with unresolved replication intermediates is not known. Here, we show that mild replication stress increases the frequency of chromosomal lesions that are transmitted to daughter cells. Throughout G1, these lesions are sequestered in nuclear compartments marked by p53-binding protein 1 (53BP1) and other chromatin-associated genome caretakers. We show that the number of such 53BP1 nuclear bodies increases after genetic ablation of BLM, a DNA helicase associated with dissolution of entangled DNA. Conversely, 53BP1 nuclear bodies are partially suppressed by knocking down SMC2, a condensin subunit required for mechanical stability of mitotic chromosomes. Finally, we provide evidence that 53BP1 nuclear bodies shield chromosomal fragile sites sequestered in these compartments against erosion. Together, these data indicate that restoration of DNA or chromatin integrity at loci prone to replication problems requires mitotic transmission to the next cell generations. More... »

PAGES

243

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2201

    DOI

    http://dx.doi.org/10.1038/ncb2201

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041212899

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21317883


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