Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10-10

AUTHORS

Rajesh Ramachandran, Blake V. Fausett, Daniel Goldman

ABSTRACT

Fish retinal regeneration starts with the dedifferentiation of glia cells into progenitors. Following injury, the proneural transcription factor, Ascl1a, upregulates the pluripotency factor Lin-28, which in turn prevents let-7 microRNA-mediated inhibition of regeneration-associated genes.

PAGES

1101-1107

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb2115

DOI

http://dx.doi.org/10.1038/ncb2115

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022628488

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20935637


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