Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07-11

AUTHORS

Paula Martinez, Maria Thanasoula, Ana R. Carlos, Gonzalo Gómez-López, Agueda M. Tejera, Stefan Schoeftner, Orlando Dominguez, David G. Pisano, Madalena Tarsounas, Maria A. Blasco

ABSTRACT

The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.

PAGES

768-780

References to SciGraph publications

  • 2002-04. Obesity therapy: altering the energy intake-and-expenditure balance sheet in NATURE REVIEWS DRUG DISCOVERY
  • 2008-11-02. An integrated system CisGenome for analyzing ChIP-chip and ChIP-seq data in NATURE BIOTECHNOLOGY
  • 2009-07. Telomerase modulates Wnt signalling by association with target gene chromatin in NATURE
  • 2007-01-21. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres in NATURE GENETICS
  • 2005-09-04. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer in NATURE GENETICS
  • 2007-12-23. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II in NATURE CELL BIOLOGY
  • 2005-01-23. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage in NATURE GENETICS
  • 2002-02. A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2003-11-05. A DNA damage checkpoint response in telomere-initiated senescence in NATURE
  • 2000-06. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP in NATURE GENETICS
  • 2008-11-25. A large genome center's improvements to the Illumina sequencing system in NATURE METHODS
  • 2000-02. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase in NATURE
  • 2001-09-27. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita in NATURE
  • 1999-12. A telomerase component is defective in the human disease dyskeratosis congenita in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2081

    DOI

    http://dx.doi.org/10.1038/ncb2081

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026329449

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20622869


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding Sites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Weight", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoblotting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reverse Transcriptase Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Telomere", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Telomere-Binding Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martinez", 
            "givenName": "Paula", 
            "id": "sg:person.01033775050.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033775050.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415084.c", 
              "name": [
                "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thanasoula", 
            "givenName": "Maria", 
            "id": "sg:person.01010061327.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010061327.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415084.c", 
              "name": [
                "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carlos", 
            "givenName": "Ana R.", 
            "id": "sg:person.0615426551.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615426551.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "G\u00f3mez-L\u00f3pez", 
            "givenName": "Gonzalo", 
            "id": "sg:person.0700636421.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tejera", 
            "givenName": "Agueda M.", 
            "id": "sg:person.01334437645.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334437645.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schoeftner", 
            "givenName": "Stefan", 
            "id": "sg:person.0613324250.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613324250.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dominguez", 
            "givenName": "Orlando", 
            "id": "sg:person.0710025320.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710025320.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pisano", 
            "givenName": "David G.", 
            "id": "sg:person.01361770421.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361770421.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.415084.c", 
              "name": [
                "Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tarsounas", 
            "givenName": "Madalena", 
            "id": "sg:person.01056471112.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056471112.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, E-28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blasco", 
            "givenName": "Maria A.", 
            "id": "sg:person.01145522156.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145522156.31"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature08137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049743007", 
              "https://doi.org/10.1038/nature08137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051483764", 
              "https://doi.org/10.1038/nbt.1505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/990141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047096543", 
              "https://doi.org/10.1038/990141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025071082", 
              "https://doi.org/10.1038/nrd770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029960866", 
              "https://doi.org/10.1038/ng1633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026732028", 
              "https://doi.org/10.1038/75973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5200775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050834720", 
              "https://doi.org/10.1038/sj.ejhg.5200775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35096585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037399358", 
              "https://doi.org/10.1038/35096585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019839382", 
              "https://doi.org/10.1038/35001622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021189255", 
              "https://doi.org/10.1038/nmeth.1270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018651818", 
              "https://doi.org/10.1038/ng1506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014616827", 
              "https://doi.org/10.1038/nature02118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007082336", 
              "https://doi.org/10.1038/ng1952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040616432", 
              "https://doi.org/10.1038/ncb1685"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-07-11", 
        "datePublishedReg": "2010-07-11", 
        "description": "The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ncb2081", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3774075", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021344", 
            "issn": [
              "1465-7392", 
              "1476-4679"
            ], 
            "name": "Nature Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "non-telomeric regions", 
          "transcriptional gene regulation", 
          "extra-telomeric functions", 
          "mammalian telomeres", 
          "shelterin components", 
          "gene regulation", 
          "gene expression", 
          "complex binds", 
          "binds", 
          "Rap1", 
          "telomeres", 
          "regulation", 
          "expression", 
          "function", 
          "sites", 
          "region", 
          "components", 
          "control", 
          "shelterin complex binds", 
          "Mammalian Rap1 controls", 
          "Rap1 controls", 
          "extratelomeric sites"
        ], 
        "name": "Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites", 
        "pagination": "768-780", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026329449"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncb2081"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20622869"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncb2081", 
          "https://app.dimensions.ai/details/publication/pub.1026329449"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_502.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ncb2081"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb2081'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb2081'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb2081'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb2081'


     

    This table displays all metadata directly associated to this object as RDF triples.

    292 TRIPLES      22 PREDICATES      82 URIs      59 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncb2081 schema:about N183631b8a3604dc395d93fc6b250b875
    2 N1de0f0fd47674fec972c428845f85d41
    3 N2e45eb3933da4e248a8be89e67edaa1a
    4 N39d977f3c34e4045b3de0a354d5415d1
    5 N5e91f589538c45fb85a2f8d5b5ef1095
    6 N6477ff68fab24c01b91cdb4da75b10e7
    7 N7a2e433aac8c49e581ad362891005184
    8 N820b3fcf0feb471ba3da58f040fa478c
    9 N87b95865a99c46388399d08d91e6f58d
    10 N8bb458760ff84499988d8f05788b855a
    11 N8e08ccf72a3e4cbfa56cd801469a7ee7
    12 Na7f6b9e925724a288b6613feb9f55d75
    13 Nab2327089679462ca2b16d5999240245
    14 Nbbfcf2f9e6cd4c95978d54486ce762b8
    15 Nbcbf8c9ce7294fa6983b0256bae62235
    16 Nd32a6ce8bfdd4afa95cf0aa67c07f0da
    17 Ndb965e9756804d80aa5b40e3b5177906
    18 Nf5a1af4ff6ee45508f7462eec528f987
    19 Nfc6d45fb8ce94e11a8b8b78bcc812fef
    20 anzsrc-for:06
    21 anzsrc-for:0601
    22 anzsrc-for:0604
    23 schema:author N185b13bec2e146f296fc973fab7bce68
    24 schema:citation sg:pub.10.1038/35001622
    25 sg:pub.10.1038/35096585
    26 sg:pub.10.1038/75973
    27 sg:pub.10.1038/990141
    28 sg:pub.10.1038/nature02118
    29 sg:pub.10.1038/nature08137
    30 sg:pub.10.1038/nbt.1505
    31 sg:pub.10.1038/ncb1685
    32 sg:pub.10.1038/ng1506
    33 sg:pub.10.1038/ng1633
    34 sg:pub.10.1038/ng1952
    35 sg:pub.10.1038/nmeth.1270
    36 sg:pub.10.1038/nrd770
    37 sg:pub.10.1038/sj.ejhg.5200775
    38 schema:datePublished 2010-07-11
    39 schema:datePublishedReg 2010-07-11
    40 schema:description The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.
    41 schema:genre article
    42 schema:inLanguage en
    43 schema:isAccessibleForFree true
    44 schema:isPartOf Nd53208cceb44449ca5119410ba506d92
    45 Ndc5d4f7a1a454ee1b7640b69f0e1cae9
    46 sg:journal.1021344
    47 schema:keywords Mammalian Rap1 controls
    48 Rap1
    49 Rap1 controls
    50 binds
    51 complex binds
    52 components
    53 control
    54 expression
    55 extra-telomeric functions
    56 extratelomeric sites
    57 function
    58 gene expression
    59 gene regulation
    60 mammalian telomeres
    61 non-telomeric regions
    62 region
    63 regulation
    64 shelterin complex binds
    65 shelterin components
    66 sites
    67 telomeres
    68 transcriptional gene regulation
    69 schema:name Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
    70 schema:pagination 768-780
    71 schema:productId N74bf601acc664c7fa95283d5cb714a86
    72 Nab6d94dafee14bd8a68e5d6d7d869b10
    73 Nebf6f9aa64ea4e7394fc38ba0a7f1486
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026329449
    75 https://doi.org/10.1038/ncb2081
    76 schema:sdDatePublished 2022-01-01T18:22
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher Nb377e2a2544e46c6ad491d0ad72ce444
    79 schema:url https://doi.org/10.1038/ncb2081
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N0638ab27e6b548909f9e3239818531f9 rdf:first sg:person.01010061327.53
    84 rdf:rest N12e9831ab0a04bbfb4fb0312e8a60cdc
    85 N12e9831ab0a04bbfb4fb0312e8a60cdc rdf:first sg:person.0615426551.06
    86 rdf:rest N869905a4c46e4e1aba2242b4dde290eb
    87 N183631b8a3604dc395d93fc6b250b875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Mice
    89 rdf:type schema:DefinedTerm
    90 N185b13bec2e146f296fc973fab7bce68 rdf:first sg:person.01033775050.53
    91 rdf:rest N0638ab27e6b548909f9e3239818531f9
    92 N1de0f0fd47674fec972c428845f85d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Mice, Knockout
    94 rdf:type schema:DefinedTerm
    95 N2e45eb3933da4e248a8be89e67edaa1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Immunoblotting
    97 rdf:type schema:DefinedTerm
    98 N39d977f3c34e4045b3de0a354d5415d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Chromatin Immunoprecipitation
    100 rdf:type schema:DefinedTerm
    101 N42e2cfc1dfc646cab716bbf97d4b907c rdf:first sg:person.01145522156.31
    102 rdf:rest rdf:nil
    103 N47245416c7b344dd89ae7772eb0bd2e3 rdf:first sg:person.01334437645.93
    104 rdf:rest N498ac3cf5ca54fdfb75e26bf1782b3ee
    105 N498ac3cf5ca54fdfb75e26bf1782b3ee rdf:first sg:person.0613324250.30
    106 rdf:rest Nf46fbf2b63e84fd083452d60a209cc74
    107 N5e91f589538c45fb85a2f8d5b5ef1095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name DNA Methylation
    109 rdf:type schema:DefinedTerm
    110 N6477ff68fab24c01b91cdb4da75b10e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Flow Cytometry
    112 rdf:type schema:DefinedTerm
    113 N74bf601acc664c7fa95283d5cb714a86 schema:name doi
    114 schema:value 10.1038/ncb2081
    115 rdf:type schema:PropertyValue
    116 N7a2e433aac8c49e581ad362891005184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Binding Sites
    118 rdf:type schema:DefinedTerm
    119 N7dcc5d5ddbd14c3980a3d6131be25718 rdf:first sg:person.01056471112.46
    120 rdf:rest N42e2cfc1dfc646cab716bbf97d4b907c
    121 N820b3fcf0feb471ba3da58f040fa478c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Reverse Transcriptase Polymerase Chain Reaction
    123 rdf:type schema:DefinedTerm
    124 N869905a4c46e4e1aba2242b4dde290eb rdf:first sg:person.0700636421.39
    125 rdf:rest N47245416c7b344dd89ae7772eb0bd2e3
    126 N87b95865a99c46388399d08d91e6f58d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Body Weight
    128 rdf:type schema:DefinedTerm
    129 N8bb458760ff84499988d8f05788b855a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Telomere-Binding Proteins
    131 rdf:type schema:DefinedTerm
    132 N8e08ccf72a3e4cbfa56cd801469a7ee7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Cell Line
    134 rdf:type schema:DefinedTerm
    135 Na0e3c579b0bb4d7f97830d502585ea9a rdf:first sg:person.01361770421.50
    136 rdf:rest N7dcc5d5ddbd14c3980a3d6131be25718
    137 Na7f6b9e925724a288b6613feb9f55d75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Immunoprecipitation
    139 rdf:type schema:DefinedTerm
    140 Nab2327089679462ca2b16d5999240245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Gene Expression Regulation
    142 rdf:type schema:DefinedTerm
    143 Nab6d94dafee14bd8a68e5d6d7d869b10 schema:name pubmed_id
    144 schema:value 20622869
    145 rdf:type schema:PropertyValue
    146 Nb377e2a2544e46c6ad491d0ad72ce444 schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 Nbbfcf2f9e6cd4c95978d54486ce762b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Humans
    150 rdf:type schema:DefinedTerm
    151 Nbcbf8c9ce7294fa6983b0256bae62235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Telomere
    153 rdf:type schema:DefinedTerm
    154 Nd32a6ce8bfdd4afa95cf0aa67c07f0da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Cell Proliferation
    156 rdf:type schema:DefinedTerm
    157 Nd53208cceb44449ca5119410ba506d92 schema:volumeNumber 12
    158 rdf:type schema:PublicationVolume
    159 Ndb965e9756804d80aa5b40e3b5177906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Fluorescent Antibody Technique
    161 rdf:type schema:DefinedTerm
    162 Ndc5d4f7a1a454ee1b7640b69f0e1cae9 schema:issueNumber 8
    163 rdf:type schema:PublicationIssue
    164 Nebf6f9aa64ea4e7394fc38ba0a7f1486 schema:name dimensions_id
    165 schema:value pub.1026329449
    166 rdf:type schema:PropertyValue
    167 Nf46fbf2b63e84fd083452d60a209cc74 rdf:first sg:person.0710025320.18
    168 rdf:rest Na0e3c579b0bb4d7f97830d502585ea9a
    169 Nf5a1af4ff6ee45508f7462eec528f987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Protein Binding
    171 rdf:type schema:DefinedTerm
    172 Nfc6d45fb8ce94e11a8b8b78bcc812fef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Animals
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Biological Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Biochemistry and Cell Biology
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Genetics
    183 rdf:type schema:DefinedTerm
    184 sg:grant.3774075 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb2081
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1021344 schema:issn 1465-7392
    187 1476-4679
    188 schema:name Nature Cell Biology
    189 schema:publisher Springer Nature
    190 rdf:type schema:Periodical
    191 sg:person.01010061327.53 schema:affiliation grid-institutes:grid.415084.c
    192 schema:familyName Thanasoula
    193 schema:givenName Maria
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010061327.53
    195 rdf:type schema:Person
    196 sg:person.01033775050.53 schema:affiliation grid-institutes:grid.7719.8
    197 schema:familyName Martinez
    198 schema:givenName Paula
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033775050.53
    200 rdf:type schema:Person
    201 sg:person.01056471112.46 schema:affiliation grid-institutes:grid.415084.c
    202 schema:familyName Tarsounas
    203 schema:givenName Madalena
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056471112.46
    205 rdf:type schema:Person
    206 sg:person.01145522156.31 schema:affiliation grid-institutes:grid.7719.8
    207 schema:familyName Blasco
    208 schema:givenName Maria A.
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145522156.31
    210 rdf:type schema:Person
    211 sg:person.01334437645.93 schema:affiliation grid-institutes:grid.7719.8
    212 schema:familyName Tejera
    213 schema:givenName Agueda M.
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334437645.93
    215 rdf:type schema:Person
    216 sg:person.01361770421.50 schema:affiliation grid-institutes:grid.7719.8
    217 schema:familyName Pisano
    218 schema:givenName David G.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361770421.50
    220 rdf:type schema:Person
    221 sg:person.0613324250.30 schema:affiliation grid-institutes:grid.7719.8
    222 schema:familyName Schoeftner
    223 schema:givenName Stefan
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613324250.30
    225 rdf:type schema:Person
    226 sg:person.0615426551.06 schema:affiliation grid-institutes:grid.415084.c
    227 schema:familyName Carlos
    228 schema:givenName Ana R.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615426551.06
    230 rdf:type schema:Person
    231 sg:person.0700636421.39 schema:affiliation grid-institutes:grid.7719.8
    232 schema:familyName Gómez-López
    233 schema:givenName Gonzalo
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39
    235 rdf:type schema:Person
    236 sg:person.0710025320.18 schema:affiliation grid-institutes:grid.7719.8
    237 schema:familyName Dominguez
    238 schema:givenName Orlando
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710025320.18
    240 rdf:type schema:Person
    241 sg:pub.10.1038/35001622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019839382
    242 https://doi.org/10.1038/35001622
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/35096585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037399358
    245 https://doi.org/10.1038/35096585
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/75973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026732028
    248 https://doi.org/10.1038/75973
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/990141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047096543
    251 https://doi.org/10.1038/990141
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature02118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014616827
    254 https://doi.org/10.1038/nature02118
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nature08137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049743007
    257 https://doi.org/10.1038/nature08137
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nbt.1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483764
    260 https://doi.org/10.1038/nbt.1505
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/ncb1685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040616432
    263 https://doi.org/10.1038/ncb1685
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/ng1506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018651818
    266 https://doi.org/10.1038/ng1506
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/ng1633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029960866
    269 https://doi.org/10.1038/ng1633
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/ng1952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007082336
    272 https://doi.org/10.1038/ng1952
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nmeth.1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021189255
    275 https://doi.org/10.1038/nmeth.1270
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nrd770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025071082
    278 https://doi.org/10.1038/nrd770
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/sj.ejhg.5200775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050834720
    281 https://doi.org/10.1038/sj.ejhg.5200775
    282 rdf:type schema:CreativeWork
    283 grid-institutes:grid.415084.c schema:alternateName Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK
    284 schema:name Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, OX3 7DQ, Oxford, UK
    285 rdf:type schema:Organization
    286 grid-institutes:grid.7719.8 schema:alternateName Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    287 Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    288 Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    289 schema:name Bioinformatics Core Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    290 Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    291 Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain
    292 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...