miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04-25

AUTHORS

Dimitrios Lagos, Gabriel Pollara, Stephen Henderson, Fiona Gratrix, Martin Fabani, Richard S.B. Milne, Frances Gotch, Chris Boshoff

ABSTRACT

Viral infection is shown to trigger CREB-mediated upregulation of miR-132. The interferon response is then downregulated by miR-132 through direct targeting of p300, a transcriptional co-activator, thereby facilitating viral replication.

PAGES

513-519

References to SciGraph publications

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  • 2007-11-11. Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA in NATURE NEUROSCIENCE
  • 2008-07-21. MicroRNAs: new regulators of immune cell development and function in NATURE IMMUNOLOGY
  • 2006-09-26. Comparative sequence analysis reveals an intricate network among REST, CREBand miRNA in mediating neuronal gene expression in GENOME BIOLOGY
  • 2005-02-16. Identification of microRNAs of the herpesvirus family in NATURE METHODS
  • 2001-02-15. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators in ONCOGENE
  • 2008-08-29. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients in ARTHRITIS RESEARCH & THERAPY
  • 2002-05-01. Aids-related malignancies in NATURE REVIEWS CANCER
  • 2004-05-24. p300/CBP and cancer in ONCOGENE
  • 2001-08. Transcriptional regulation by the phosphorylation-dependent factor CREB in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-02. Micromanagement of the immune system by microRNAs in NATURE REVIEWS IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb2054

    DOI

    http://dx.doi.org/10.1038/ncb2054

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040711177

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20418869


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