RAD18 transmits DNA damage signalling to elicit homologous recombination repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05

AUTHORS

Jun Huang, Michael S. Y. Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu, Junjie Chen

ABSTRACT

To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair. Cell-cycle checkpoint controls should connect with DNA repair processes, however, exactly how such coordination occurs in vivo is largely unknown. Here we describe a new role for the E3 ligase RAD18 as the integral component in translating the damage response signal to orchestrate homologous recombination repair (HRR). We show that RAD18 promotes homologous recombination in a manner strictly dependent on its ability to be recruited to sites of DNA breaks and that this recruitment relies on a well-defined DNA damage signalling pathway mediated by another E3 ligase, RNF8. We further demonstrate that RAD18 functions as an adaptor to facilitate homologous recombination through direct interaction with the recombinase RAD51C. Together, our data uncovers RAD18 as a key factor that orchestrates HRR through surveillance of the DNA damage signal. More... »

PAGES

592-603

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1865

DOI

http://dx.doi.org/10.1038/ncb1865

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046079148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19396164


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Conversion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Domains and Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Conjugating Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc Fingers", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jun", 
        "id": "sg:person.010130104617.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010130104617.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huen", 
        "givenName": "Michael S. Y.", 
        "id": "sg:person.010377533767.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010377533767.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hongtae", 
        "id": "sg:person.010165033327.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010165033327.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leung", 
        "givenName": "Charles Chung Yun", 
        "id": "sg:person.01261776606.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261776606.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Glover", 
        "givenName": "J N Mark", 
        "id": "sg:person.01232110650.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232110650.42"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yu", 
        "givenName": "Xiaochun", 
        "id": "sg:person.0746521555.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746521555.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Junjie", 
        "id": "sg:person.015161500207.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015161500207.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.01291-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001965462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003569111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003668474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003668474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003736309", 
          "https://doi.org/10.1038/nsmb1277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.8.2858-2866.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003825698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01243-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004301752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.2.474-481.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004658001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005294665", 
          "https://doi.org/10.1038/nature03485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005294665", 
          "https://doi.org/10.1038/nature03485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326381", 
          "https://doi.org/10.1038/86920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326381", 
          "https://doi.org/10.1038/86920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.947001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005342722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2006.05.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005859081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.09.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007817477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.09.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007817477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008683677", 
          "https://doi.org/10.1038/nature00991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008683677", 
          "https://doi.org/10.1038/nature00991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2007.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010057936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010164936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012198218", 
          "https://doi.org/10.1038/ncb1212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012198218", 
          "https://doi.org/10.1038/ncb1212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m609066200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012937072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2004.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013468078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.10.2172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014235402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016441336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200608130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016785860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0710061104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017703994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019126921", 
          "https://doi.org/10.1038/nrm1127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019126921", 
          "https://doi.org/10.1038/nrm1127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019335990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019335990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.09.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021885296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0304-184a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023180731", 
          "https://doi.org/10.1038/ncb0304-184a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0304-184a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023180731", 
          "https://doi.org/10.1038/ncb0304-184a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308621200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023287038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80276-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023606878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1431006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025912102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026406086", 
          "https://doi.org/10.1038/nature01408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026406086", 
          "https://doi.org/10.1038/nature01408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2006.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026998772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027480321", 
          "https://doi.org/10.1038/35077232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027480321", 
          "https://doi.org/10.1038/35077232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030114642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033224102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/24.2.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035241659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m201402200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035563385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037091000", 
          "https://doi.org/10.1038/nature03482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037091000", 
          "https://doi.org/10.1038/nature03482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.14.7927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039511320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.935501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042143015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00567-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043198083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1150034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044949826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045481140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(94)90196-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046819487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(94)90196-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046819487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00566-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047569593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049576974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049639917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051713472", 
          "https://doi.org/10.1038/nature06337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052028223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(05)09031-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053393700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1093037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1143700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.4171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204270"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-05", 
    "datePublishedReg": "2009-05-01", 
    "description": "To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair. Cell-cycle checkpoint controls should connect with DNA repair processes, however, exactly how such coordination occurs in vivo is largely unknown. Here we describe a new role for the E3 ligase RAD18 as the integral component in translating the damage response signal to orchestrate homologous recombination repair (HRR). We show that RAD18 promotes homologous recombination in a manner strictly dependent on its ability to be recruited to sites of DNA breaks and that this recruitment relies on a well-defined DNA damage signalling pathway mediated by another E3 ligase, RNF8. We further demonstrate that RAD18 functions as an adaptor to facilitate homologous recombination through direct interaction with the recombinase RAD51C. Together, our data uncovers RAD18 as a key factor that orchestrates HRR through surveillance of the DNA damage signal.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb1865", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2479594", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479766", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2475671", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7135006", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2475252", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "RAD18 transmits DNA damage signalling to elicit homologous recombination repair", 
    "pagination": "592-603", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1865"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046079148"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "db7f007f7968842a6e895f2e5c2dc82fc1f14d7be287120ea29253c292a0a1ba"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19396164"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1865", 
      "https://app.dimensions.ai/details/publication/pub.1046079148"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106822_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ncb1865"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1865'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1865'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1865'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1865'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      103 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1865 schema:about N127f7e0092ab4515bd2a8da2623879a3
2 N1864e79cf4b9472d90aaaf5ee7780342
3 N25099c9e298a4b0d8c3619da7e9781b8
4 N2bb2ef9382794d078f6807480ba97bfb
5 N2e1aee605440467a80a5bfd72b227f27
6 N51a7b4e93e7144eeafcedac6f68188af
7 N5908f157987c458eb696cba772bac15a
8 N64ab997593e6426493ea0cc4bd3ffcb6
9 N6a8ba586c2ee4a9eaa9c86b3c6cd9d15
10 N6dd9a56ca15e45bb8f4d6ee3f0aa1f4a
11 N74464e1f835a43918673d979d2f30fdc
12 N8566ac6b767f4ccabe53e7d1631e583f
13 N8ac0e4aea0e6459b952f32f003525fe4
14 N94c0f20d72ee415ba4681b1e2cd4ab43
15 Naa0c214efbe542ee92b0f0bcf9faa5d2
16 Naac802f20fa64bf1845ae54c8a2be3ef
17 Nb7be3cdf8e124ceea2db29190c63962b
18 Nc3abf8de0a3f46f1a99b52ec745ffb4a
19 Nc5f49d7b0bb040d0a9b3ed9093c46f8f
20 Nd00482dac897493695fa21a5faf6faaf
21 Ne0d6d68a759f42b984ee6aca823d0eaf
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author N606dd66dcc924572965aab5efebedf70
25 schema:citation sg:pub.10.1038/35077232
26 sg:pub.10.1038/86920
27 sg:pub.10.1038/nature00991
28 sg:pub.10.1038/nature01408
29 sg:pub.10.1038/nature03482
30 sg:pub.10.1038/nature03485
31 sg:pub.10.1038/nature06337
32 sg:pub.10.1038/ncb0304-184a
33 sg:pub.10.1038/ncb1212
34 sg:pub.10.1038/nrm1127
35 sg:pub.10.1038/nsmb1277
36 https://doi.org/10.1002/jcb.20587
37 https://doi.org/10.1016/0378-1119(94)90196-1
38 https://doi.org/10.1016/j.canlet.2004.08.018
39 https://doi.org/10.1016/j.ceb.2007.02.009
40 https://doi.org/10.1016/j.cell.2004.09.006
41 https://doi.org/10.1016/j.cell.2007.09.040
42 https://doi.org/10.1016/j.cell.2007.09.041
43 https://doi.org/10.1016/j.dnarep.2004.03.024
44 https://doi.org/10.1016/j.dnarep.2006.05.028
45 https://doi.org/10.1016/j.dnarep.2006.05.045
46 https://doi.org/10.1016/j.molcel.2007.01.029
47 https://doi.org/10.1016/s0076-6879(05)09031-2
48 https://doi.org/10.1016/s0092-8674(03)00566-x
49 https://doi.org/10.1016/s0092-8674(03)00567-1
50 https://doi.org/10.1016/s1097-2765(00)80276-2
51 https://doi.org/10.1038/sj.emboj.7600383
52 https://doi.org/10.1038/sj.emboj.7600914
53 https://doi.org/10.1038/sj.emboj.7601102
54 https://doi.org/10.1073/pnas.0710061104
55 https://doi.org/10.1073/pnas.97.14.7927
56 https://doi.org/10.1074/jbc.m201402200
57 https://doi.org/10.1074/jbc.m308621200
58 https://doi.org/10.1074/jbc.m609066200
59 https://doi.org/10.1083/jcb.200608130
60 https://doi.org/10.1093/carcin/24.2.249
61 https://doi.org/10.1093/emboj/cdf534
62 https://doi.org/10.1093/hmg/ddh095
63 https://doi.org/10.1093/nar/30.10.2172
64 https://doi.org/10.1101/gad.1431006
65 https://doi.org/10.1101/gad.935501
66 https://doi.org/10.1101/gad.947001
67 https://doi.org/10.1126/science.1093037
68 https://doi.org/10.1126/science.1139476
69 https://doi.org/10.1126/science.1139516
70 https://doi.org/10.1126/science.1139621
71 https://doi.org/10.1126/science.1143700
72 https://doi.org/10.1126/science.1150034
73 https://doi.org/10.1128/mcb.01243-06
74 https://doi.org/10.1128/mcb.01291-06
75 https://doi.org/10.1128/mcb.21.8.2858-2866.2001
76 https://doi.org/10.1128/mcb.23.2.474-481.2003
77 https://doi.org/10.1200/jco.2005.05.4171
78 schema:datePublished 2009-05
79 schema:datePublishedReg 2009-05-01
80 schema:description To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair. Cell-cycle checkpoint controls should connect with DNA repair processes, however, exactly how such coordination occurs in vivo is largely unknown. Here we describe a new role for the E3 ligase RAD18 as the integral component in translating the damage response signal to orchestrate homologous recombination repair (HRR). We show that RAD18 promotes homologous recombination in a manner strictly dependent on its ability to be recruited to sites of DNA breaks and that this recruitment relies on a well-defined DNA damage signalling pathway mediated by another E3 ligase, RNF8. We further demonstrate that RAD18 functions as an adaptor to facilitate homologous recombination through direct interaction with the recombinase RAD51C. Together, our data uncovers RAD18 as a key factor that orchestrates HRR through surveillance of the DNA damage signal.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N9fa184243a5849aca4e179fc12c1ba44
85 Nc9be86dee9294b31ba6f232d2ec4a478
86 sg:journal.1021344
87 schema:name RAD18 transmits DNA damage signalling to elicit homologous recombination repair
88 schema:pagination 592-603
89 schema:productId N5621163cb90c424c85ca3100ab951ab3
90 N9f3a3f3e52db4e9198b573bbde10dd2b
91 Nb1d2c54448644d298804f7c02b34eaf3
92 Nd083bc1aaa4648c6ad71f6be65f04f17
93 Nd519f0a3b8ab4a7ca09bf5b772bd6878
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046079148
95 https://doi.org/10.1038/ncb1865
96 schema:sdDatePublished 2019-04-16T06:23
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N62fa05f995474d89bf52adcabd677d4c
99 schema:url http://www.nature.com/articles/ncb1865
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N127f7e0092ab4515bd2a8da2623879a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Chromatin
105 rdf:type schema:DefinedTerm
106 N1864e79cf4b9472d90aaaf5ee7780342 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Protein Interaction Domains and Motifs
108 rdf:type schema:DefinedTerm
109 N25099c9e298a4b0d8c3619da7e9781b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Signal Transduction
111 rdf:type schema:DefinedTerm
112 N2bb2ef9382794d078f6807480ba97bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name DNA Breaks, Double-Stranded
114 rdf:type schema:DefinedTerm
115 N2e1aee605440467a80a5bfd72b227f27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Zinc Fingers
117 rdf:type schema:DefinedTerm
118 N42089a030a5748f8802b464ba6b1507e rdf:first sg:person.01261776606.22
119 rdf:rest N45acb43d27db4ece8fba4da1bbffcc24
120 N45acb43d27db4ece8fba4da1bbffcc24 rdf:first sg:person.01232110650.42
121 rdf:rest N4c25f333c1ac49d8961345950774ce1b
122 N4c25f333c1ac49d8961345950774ce1b rdf:first sg:person.0746521555.82
123 rdf:rest N60687239ab28480eae86cb4707d98184
124 N51a7b4e93e7144eeafcedac6f68188af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Ubiquitin-Conjugating Enzymes
126 rdf:type schema:DefinedTerm
127 N5621163cb90c424c85ca3100ab951ab3 schema:name pubmed_id
128 schema:value 19396164
129 rdf:type schema:PropertyValue
130 N5908f157987c458eb696cba772bac15a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Models, Biological
132 rdf:type schema:DefinedTerm
133 N60687239ab28480eae86cb4707d98184 rdf:first sg:person.015161500207.26
134 rdf:rest rdf:nil
135 N606dd66dcc924572965aab5efebedf70 rdf:first sg:person.010130104617.84
136 rdf:rest N919351ef558e4e5283b09090357acad9
137 N62fa05f995474d89bf52adcabd677d4c schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N64ab997593e6426493ea0cc4bd3ffcb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name DNA Damage
141 rdf:type schema:DefinedTerm
142 N6a8ba586c2ee4a9eaa9c86b3c6cd9d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N6dd9a56ca15e45bb8f4d6ee3f0aa1f4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name DNA
147 rdf:type schema:DefinedTerm
148 N74464e1f835a43918673d979d2f30fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Camptothecin
150 rdf:type schema:DefinedTerm
151 N8566ac6b767f4ccabe53e7d1631e583f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name DNA Repair
153 rdf:type schema:DefinedTerm
154 N8ac0e4aea0e6459b952f32f003525fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Ubiquitin-Protein Ligases
156 rdf:type schema:DefinedTerm
157 N919351ef558e4e5283b09090357acad9 rdf:first sg:person.010377533767.04
158 rdf:rest Nd36f39748b1244ad82f757b861d9b09f
159 N94c0f20d72ee415ba4681b1e2cd4ab43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Gene Conversion
161 rdf:type schema:DefinedTerm
162 N9f3a3f3e52db4e9198b573bbde10dd2b schema:name dimensions_id
163 schema:value pub.1046079148
164 rdf:type schema:PropertyValue
165 N9fa184243a5849aca4e179fc12c1ba44 schema:volumeNumber 11
166 rdf:type schema:PublicationVolume
167 Naa0c214efbe542ee92b0f0bcf9faa5d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Recombination, Genetic
169 rdf:type schema:DefinedTerm
170 Naac802f20fa64bf1845ae54c8a2be3ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Protein Binding
172 rdf:type schema:DefinedTerm
173 Nb1d2c54448644d298804f7c02b34eaf3 schema:name doi
174 schema:value 10.1038/ncb1865
175 rdf:type schema:PropertyValue
176 Nb7be3cdf8e124ceea2db29190c63962b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Histones
178 rdf:type schema:DefinedTerm
179 Nc3abf8de0a3f46f1a99b52ec745ffb4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name HeLa Cells
181 rdf:type schema:DefinedTerm
182 Nc5f49d7b0bb040d0a9b3ed9093c46f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Ubiquitin
184 rdf:type schema:DefinedTerm
185 Nc9be86dee9294b31ba6f232d2ec4a478 schema:issueNumber 5
186 rdf:type schema:PublicationIssue
187 Nd00482dac897493695fa21a5faf6faaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cell Line
189 rdf:type schema:DefinedTerm
190 Nd083bc1aaa4648c6ad71f6be65f04f17 schema:name nlm_unique_id
191 schema:value 100890575
192 rdf:type schema:PropertyValue
193 Nd36f39748b1244ad82f757b861d9b09f rdf:first sg:person.010165033327.93
194 rdf:rest N42089a030a5748f8802b464ba6b1507e
195 Nd519f0a3b8ab4a7ca09bf5b772bd6878 schema:name readcube_id
196 schema:value db7f007f7968842a6e895f2e5c2dc82fc1f14d7be287120ea29253c292a0a1ba
197 rdf:type schema:PropertyValue
198 Ne0d6d68a759f42b984ee6aca823d0eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name DNA-Binding Proteins
200 rdf:type schema:DefinedTerm
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:grant.2475252 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1865
208 rdf:type schema:MonetaryGrant
209 sg:grant.2475671 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1865
210 rdf:type schema:MonetaryGrant
211 sg:grant.2479594 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1865
212 rdf:type schema:MonetaryGrant
213 sg:grant.2479766 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1865
214 rdf:type schema:MonetaryGrant
215 sg:grant.7135006 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1865
216 rdf:type schema:MonetaryGrant
217 sg:journal.1021344 schema:issn 1465-7392
218 1476-4679
219 schema:name Nature Cell Biology
220 rdf:type schema:Periodical
221 sg:person.010130104617.84 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
222 schema:familyName Huang
223 schema:givenName Jun
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010130104617.84
225 rdf:type schema:Person
226 sg:person.010165033327.93 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
227 schema:familyName Kim
228 schema:givenName Hongtae
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010165033327.93
230 rdf:type schema:Person
231 sg:person.010377533767.04 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
232 schema:familyName Huen
233 schema:givenName Michael S. Y.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010377533767.04
235 rdf:type schema:Person
236 sg:person.01232110650.42 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
237 schema:familyName Glover
238 schema:givenName J N Mark
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232110650.42
240 rdf:type schema:Person
241 sg:person.01261776606.22 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
242 schema:familyName Leung
243 schema:givenName Charles Chung Yun
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261776606.22
245 rdf:type schema:Person
246 sg:person.015161500207.26 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
247 schema:familyName Chen
248 schema:givenName Junjie
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015161500207.26
250 rdf:type schema:Person
251 sg:person.0746521555.82 schema:familyName Yu
252 schema:givenName Xiaochun
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746521555.82
254 rdf:type schema:Person
255 sg:pub.10.1038/35077232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027480321
256 https://doi.org/10.1038/35077232
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/86920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005326381
259 https://doi.org/10.1038/86920
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature00991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008683677
262 https://doi.org/10.1038/nature00991
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nature01408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026406086
265 https://doi.org/10.1038/nature01408
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
268 https://doi.org/10.1038/nature03482
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nature03485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005294665
271 https://doi.org/10.1038/nature03485
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nature06337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051713472
274 https://doi.org/10.1038/nature06337
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ncb0304-184a schema:sameAs https://app.dimensions.ai/details/publication/pub.1023180731
277 https://doi.org/10.1038/ncb0304-184a
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ncb1212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012198218
280 https://doi.org/10.1038/ncb1212
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nrm1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019126921
283 https://doi.org/10.1038/nrm1127
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nsmb1277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003736309
286 https://doi.org/10.1038/nsmb1277
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/jcb.20587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019335990
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/0378-1119(94)90196-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046819487
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.canlet.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013468078
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.ceb.2007.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010057936
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.cell.2004.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052028223
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.cell.2007.09.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021885296
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.cell.2007.09.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007817477
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.dnarep.2004.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030114642
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.dnarep.2006.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026998772
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.dnarep.2006.05.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005859081
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.molcel.2007.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033224102
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0076-6879(05)09031-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053393700
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0092-8674(03)00566-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047569593
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0092-8674(03)00567-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043198083
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s1097-2765(00)80276-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023606878
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1038/sj.emboj.7600383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016441336
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1038/sj.emboj.7600914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003668474
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1038/sj.emboj.7601102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010164936
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.0710061104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017703994
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.97.14.7927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039511320
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1074/jbc.m201402200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035563385
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.m308621200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023287038
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.m609066200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012937072
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1083/jcb.200608130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016785860
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/carcin/24.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035241659
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/emboj/cdf534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003569111
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/hmg/ddh095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049576974
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/nar/30.10.2172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014235402
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1101/gad.1431006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025912102
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1101/gad.935501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042143015
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.947001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005342722
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.1093037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449247
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1126/science.1139476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010913917
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1126/science.1139516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045481140
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1126/science.1139621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049639917
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1126/science.1143700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456109
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1126/science.1150034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044949826
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1128/mcb.01243-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004301752
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1128/mcb.01291-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965462
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1128/mcb.21.8.2858-2866.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003825698
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1128/mcb.23.2.474-481.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004658001
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1200/jco.2005.05.4171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204270
371 rdf:type schema:CreativeWork
372 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
373 schema:name Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
376 schema:name Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520, USA.
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...