Tethering by lamin A stabilizes and targets the ING1 tumour suppressor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

Xijing Han, Xiaolan Feng, Jerome B Rattner, Heather Smith, Pinaki Bose, Keiko Suzuki, Mohamed A Soliman, Michelle S Scott, Brian E Burke, Karl Riabowol

ABSTRACT

ING proteins interact with core histones through their plant homeodomains (PHDs) and with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to alter chromatin structure. Here we identify a lamin interaction domain (LID) found only in ING proteins, through which they bind to and colocalize with lamin A. Lamin knockout (LMNA(-/-)) cells show reduced levels of ING1 that mislocalize. Ectopic lamin A expression increases ING1 levels and re-targets it to the nucleus to act as an epigenetic regulator. ING1 lacking the LID does not interact with lamin A or affect apoptosis. In LMNA(-/-) cells, apoptosis is not affected by ING1. Mutation of lamin A results in several laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), a severe premature ageing disorder. HGPS cells have reduced ING1 levels that mislocalize. Expression of LID peptides to block lamin A-ING1 interaction induces phenotypes reminiscent of laminopathies including HGPS. These data show that targeting of ING1 to the nucleus by lamin A maintains ING1 levels and biological function. Known roles for ING proteins in regulating apoptosis and chromatin structure indicate that loss of lamin A-ING interaction may be an effector of lamin A loss, contributing to the HGPS phenotype. More... »

PAGES

1333-1340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1792

DOI

http://dx.doi.org/10.1038/ncb1792

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032211996

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18836436


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibitor of Growth Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lamin Type A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Progeria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Departments of Biochemistry & Molecular Biology and Oncology, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Xijing", 
        "id": "sg:person.01340701133.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340701133.98"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Feng", 
        "givenName": "Xiaolan", 
        "id": "sg:person.01240423151.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240423151.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Rattner", 
        "givenName": "Jerome B", 
        "id": "sg:person.01145732353.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145732353.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Smith", 
        "givenName": "Heather", 
        "id": "sg:person.01114065233.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114065233.37"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bose", 
        "givenName": "Pinaki", 
        "id": "sg:person.0634763317.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634763317.49"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Suzuki", 
        "givenName": "Keiko", 
        "id": "sg:person.0735145555.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735145555.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Soliman", 
        "givenName": "Mohamed A", 
        "id": "sg:person.01054513463.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054513463.85"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Scott", 
        "givenName": "Michelle S", 
        "id": "sg:person.0720557054.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720557054.76"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Burke", 
        "givenName": "Brian E", 
        "id": "sg:person.0607572136.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607572136.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Riabowol", 
        "givenName": "Karl", 
        "id": "sg:person.0626555326.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626555326.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000386876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.131.1.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001020478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402943101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003021148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.56.7.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004289649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.8.2918-2932.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005142700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genom.7.080505.115732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008214167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2007.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008959937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00573-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010450745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.147.5.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012213633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012227594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200600682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014593973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00401-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018706213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.11.3807-3816.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021541738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00047.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022291790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200197200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025619597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602569103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026721109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0403250101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026766865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.15.6639-6648.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028433379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.151.6.1155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029411876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.4.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033055864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036643627", 
          "https://doi.org/10.1038/nature04835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036643627", 
          "https://doi.org/10.1038/nature04835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036643627", 
          "https://doi.org/10.1038/nature04835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036760289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2007.07.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040594426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2006.11.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043260261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044644198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2008.00393.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048607646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051533206", 
          "https://doi.org/10.1038/nature01629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051533206", 
          "https://doi.org/10.1038/nature01629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051757694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.3.835-848.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052032823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msh256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053566230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074527852", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074946766", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075097673", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082630920", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "ING proteins interact with core histones through their plant homeodomains (PHDs) and with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to alter chromatin structure. Here we identify a lamin interaction domain (LID) found only in ING proteins, through which they bind to and colocalize with lamin A. Lamin knockout (LMNA(-/-)) cells show reduced levels of ING1 that mislocalize. Ectopic lamin A expression increases ING1 levels and re-targets it to the nucleus to act as an epigenetic regulator. ING1 lacking the LID does not interact with lamin A or affect apoptosis. In LMNA(-/-) cells, apoptosis is not affected by ING1. Mutation of lamin A results in several laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), a severe premature ageing disorder. HGPS cells have reduced ING1 levels that mislocalize. Expression of LID peptides to block lamin A-ING1 interaction induces phenotypes reminiscent of laminopathies including HGPS. These data show that targeting of ING1 to the nucleus by lamin A maintains ING1 levels and biological function. Known roles for ING proteins in regulating apoptosis and chromatin structure indicate that loss of lamin A-ING interaction may be an effector of lamin A loss, contributing to the HGPS phenotype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb1792", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Tethering by lamin A stabilizes and targets the ING1 tumour suppressor", 
    "pagination": "1333-1340", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "99736d8c98f6bee8dad9092d5e0361ae1480d5529e6dc73c018e82b80a589906"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18836436"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1792"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032211996"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1792", 
      "https://app.dimensions.ai/details/publication/pub.1032211996"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncb/journal/v10/n11/full/ncb1792.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1792'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1792'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1792'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1792'


 

This table displays all metadata directly associated to this object as RDF triples.

327 TRIPLES      21 PREDICATES      89 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1792 schema:about N0b0f324e411c4e3c9c03226b256ee813
2 N29cc8b2beb544049be1cb2a13c445651
3 N332b9e566f7f4d8c9e511564ca834d74
4 N37498f6d57584c13b75290e1e5793cd2
5 N46bcd32dbb494a2f8dbdd25d24ae96ee
6 N4d664647c61e49559388e3fa465e1e42
7 N507c9e1e44b44c8ba85883b6fa746d87
8 N5c7e3dbf39e54a22997bc80dd945ff23
9 N6ed37390c13443b5a10910a53e526d05
10 N6f29852e706d417f8cc150dffcb321cc
11 N7d5c31a7ee544321aa8d2f38ac924dd5
12 N829286a83ba7412f9b8ecbb0ac490ec0
13 Na3f75563c0fc4f4f9a3aadc38ae555f8
14 Na82c88ec6c7d450aa5768fee17ce3ac5
15 Nabc8611a63a0423e84dbe83dc41b4c0f
16 Nabf1bdc9d1c248d99f85942a55298715
17 Naf8f14e8dfc64156ad95e7939f59da35
18 Nafca2e0d27144030ba514ff1984ab533
19 Nba470fd7698f418cb6529871355bca34
20 Nbb019b8f0ed547149cd584ed7f678881
21 Nc4f111f6f5124160bc084ad7d1dba689
22 Ndb565cc003524e77aabe9789ed3e6a51
23 Ne0cdcc9540f84c7181e7fe9f7f92cc87
24 Ne13bc2da5681458587dd97dbfafc9044
25 Nf4748713fcb947ea99d31d5055730880
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author Nb227157d0b844d2ca57aa7c62a11335c
29 schema:citation sg:pub.10.1038/nature01629
30 sg:pub.10.1038/nature04814
31 sg:pub.10.1038/nature04835
32 https://app.dimensions.ai/details/publication/pub.1074527852
33 https://app.dimensions.ai/details/publication/pub.1074946766
34 https://app.dimensions.ai/details/publication/pub.1075097673
35 https://app.dimensions.ai/details/publication/pub.1082630920
36 https://doi.org/10.1002/pmic.200600682
37 https://doi.org/10.1016/j.febslet.2006.11.055
38 https://doi.org/10.1016/j.molcel.2005.12.007
39 https://doi.org/10.1016/j.molcel.2006.10.026
40 https://doi.org/10.1016/j.tibs.2007.08.006
41 https://doi.org/10.1016/j.yexcr.2007.07.029
42 https://doi.org/10.1016/s0092-8674(03)00401-x
43 https://doi.org/10.1073/pnas.0402943101
44 https://doi.org/10.1073/pnas.0403250101
45 https://doi.org/10.1073/pnas.0602569103
46 https://doi.org/10.1074/jbc.m200197200
47 https://doi.org/10.1083/jcb.131.1.33
48 https://doi.org/10.1083/jcb.147.5.913
49 https://doi.org/10.1083/jcb.151.6.1155
50 https://doi.org/10.1093/molbev/msh256
51 https://doi.org/10.1111/j.1474-9726.2008.00393.x
52 https://doi.org/10.1128/mcb.00573-06
53 https://doi.org/10.1128/mcb.17.4.2014
54 https://doi.org/10.1128/mcb.20.11.3807-3816.2000
55 https://doi.org/10.1128/mcb.21.8.2918-2932.2001
56 https://doi.org/10.1128/mcb.22.3.835-848.2002
57 https://doi.org/10.1128/mcb.25.15.6639-6648.2005
58 https://doi.org/10.1136/jcp.56.7.507
59 https://doi.org/10.1146/annurev.genom.7.080505.115732
60 https://doi.org/10.1152/physrev.00047.2005
61 https://doi.org/10.1158/0008-5472.can-05-3444
62 https://doi.org/10.1158/0008-5472.can-06-3558
63 https://doi.org/10.1242/jcs.01102
64 schema:datePublished 2008-11
65 schema:datePublishedReg 2008-11-01
66 schema:description ING proteins interact with core histones through their plant homeodomains (PHDs) and with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to alter chromatin structure. Here we identify a lamin interaction domain (LID) found only in ING proteins, through which they bind to and colocalize with lamin A. Lamin knockout (LMNA(-/-)) cells show reduced levels of ING1 that mislocalize. Ectopic lamin A expression increases ING1 levels and re-targets it to the nucleus to act as an epigenetic regulator. ING1 lacking the LID does not interact with lamin A or affect apoptosis. In LMNA(-/-) cells, apoptosis is not affected by ING1. Mutation of lamin A results in several laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), a severe premature ageing disorder. HGPS cells have reduced ING1 levels that mislocalize. Expression of LID peptides to block lamin A-ING1 interaction induces phenotypes reminiscent of laminopathies including HGPS. These data show that targeting of ING1 to the nucleus by lamin A maintains ING1 levels and biological function. Known roles for ING proteins in regulating apoptosis and chromatin structure indicate that loss of lamin A-ING interaction may be an effector of lamin A loss, contributing to the HGPS phenotype.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N7111d5a1a18d4bb8be0cfa08390c3ab3
71 Nfb3179b0f9ec422c8061e29a86024016
72 sg:journal.1021344
73 schema:name Tethering by lamin A stabilizes and targets the ING1 tumour suppressor
74 schema:pagination 1333-1340
75 schema:productId N52b0585c734f4ec6bff41f218bb4ca63
76 N74531c8cf13048c6b69014be4ccc20c2
77 Nab29509374b042bd8d96648a77e83b03
78 Nac6a02dba8d94b19a2382569ac158aa6
79 Nd1255722234f4cf49ab4230c1e3dedce
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032211996
81 https://doi.org/10.1038/ncb1792
82 schema:sdDatePublished 2019-04-10T23:12
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N302df7a57fda4706b3828f50891f36e0
85 schema:url http://www.nature.com/ncb/journal/v10/n11/full/ncb1792.html
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0b0f324e411c4e3c9c03226b256ee813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Protein Structure, Tertiary
91 rdf:type schema:DefinedTerm
92 N29cc8b2beb544049be1cb2a13c445651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Amino Acid Sequence
94 rdf:type schema:DefinedTerm
95 N302df7a57fda4706b3828f50891f36e0 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N332b9e566f7f4d8c9e511564ca834d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Chromosome Mapping
99 rdf:type schema:DefinedTerm
100 N37498f6d57584c13b75290e1e5793cd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Lamin Type A
102 rdf:type schema:DefinedTerm
103 N43a893bac9254140a4e4582e0087b576 rdf:first sg:person.01145732353.17
104 rdf:rest Nd781e225867d4805bb7e4d688b543b53
105 N46bcd32dbb494a2f8dbdd25d24ae96ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N4d664647c61e49559388e3fa465e1e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Embryonic Stem Cells
110 rdf:type schema:DefinedTerm
111 N507c9e1e44b44c8ba85883b6fa746d87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Inhibitor of Growth Protein 1
113 rdf:type schema:DefinedTerm
114 N52b0585c734f4ec6bff41f218bb4ca63 schema:name pubmed_id
115 schema:value 18836436
116 rdf:type schema:PropertyValue
117 N5c7e3dbf39e54a22997bc80dd945ff23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Nuclear Proteins
119 rdf:type schema:DefinedTerm
120 N68ece4906d94481bbcd46146bf8a4847 rdf:first sg:person.0634763317.49
121 rdf:rest Nfcfcf52ace6149419872029da82463ba
122 N6ed37390c13443b5a10910a53e526d05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Fibroblasts
124 rdf:type schema:DefinedTerm
125 N6f29852e706d417f8cc150dffcb321cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Molecular Sequence Data
127 rdf:type schema:DefinedTerm
128 N7111d5a1a18d4bb8be0cfa08390c3ab3 schema:volumeNumber 10
129 rdf:type schema:PublicationVolume
130 N73e217add6e24fc5ad685b02854f2d13 rdf:first sg:person.0626555326.43
131 rdf:rest rdf:nil
132 N74531c8cf13048c6b69014be4ccc20c2 schema:name dimensions_id
133 schema:value pub.1032211996
134 rdf:type schema:PropertyValue
135 N7d5c31a7ee544321aa8d2f38ac924dd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Transfection
137 rdf:type schema:DefinedTerm
138 N829286a83ba7412f9b8ecbb0ac490ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Amino Acid Motifs
140 rdf:type schema:DefinedTerm
141 N93c248a73e6f46a9b56665b120b8fa58 rdf:first sg:person.0720557054.76
142 rdf:rest Ndd4539f63bc3416b82208a7414f7b03c
143 Na3f75563c0fc4f4f9a3aadc38ae555f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 Na82c88ec6c7d450aa5768fee17ce3ac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Chromatin
148 rdf:type schema:DefinedTerm
149 Naa39cf8b02d3406988cc9692243956fc rdf:first sg:person.01054513463.85
150 rdf:rest N93c248a73e6f46a9b56665b120b8fa58
151 Nab29509374b042bd8d96648a77e83b03 schema:name readcube_id
152 schema:value 99736d8c98f6bee8dad9092d5e0361ae1480d5529e6dc73c018e82b80a589906
153 rdf:type schema:PropertyValue
154 Nabc8611a63a0423e84dbe83dc41b4c0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mutation
156 rdf:type schema:DefinedTerm
157 Nabf1bdc9d1c248d99f85942a55298715 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice
159 rdf:type schema:DefinedTerm
160 Nac6a02dba8d94b19a2382569ac158aa6 schema:name nlm_unique_id
161 schema:value 100890575
162 rdf:type schema:PropertyValue
163 Naf8f14e8dfc64156ad95e7939f59da35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cells, Cultured
165 rdf:type schema:DefinedTerm
166 Nafca2e0d27144030ba514ff1984ab533 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Intracellular Signaling Peptides and Proteins
168 rdf:type schema:DefinedTerm
169 Nb227157d0b844d2ca57aa7c62a11335c rdf:first sg:person.01340701133.98
170 rdf:rest Ne2ffce123a574e4db1dc8365ef528c2f
171 Nba470fd7698f418cb6529871355bca34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Progeria
173 rdf:type schema:DefinedTerm
174 Nbb019b8f0ed547149cd584ed7f678881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cell Nucleus
176 rdf:type schema:DefinedTerm
177 Nc4f111f6f5124160bc084ad7d1dba689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Genes, Tumor Suppressor
179 rdf:type schema:DefinedTerm
180 Nd1255722234f4cf49ab4230c1e3dedce schema:name doi
181 schema:value 10.1038/ncb1792
182 rdf:type schema:PropertyValue
183 Nd781e225867d4805bb7e4d688b543b53 rdf:first sg:person.01114065233.37
184 rdf:rest N68ece4906d94481bbcd46146bf8a4847
185 Ndb565cc003524e77aabe9789ed3e6a51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Sequence Homology, Amino Acid
187 rdf:type schema:DefinedTerm
188 Ndd4539f63bc3416b82208a7414f7b03c rdf:first sg:person.0607572136.09
189 rdf:rest N73e217add6e24fc5ad685b02854f2d13
190 Ne0cdcc9540f84c7181e7fe9f7f92cc87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Kidney
192 rdf:type schema:DefinedTerm
193 Ne13bc2da5681458587dd97dbfafc9044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Tumor Suppressor Proteins
195 rdf:type schema:DefinedTerm
196 Ne2ffce123a574e4db1dc8365ef528c2f rdf:first sg:person.01240423151.11
197 rdf:rest N43a893bac9254140a4e4582e0087b576
198 Nf4748713fcb947ea99d31d5055730880 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Cell Line
200 rdf:type schema:DefinedTerm
201 Nfb3179b0f9ec422c8061e29a86024016 schema:issueNumber 11
202 rdf:type schema:PublicationIssue
203 Nfcfcf52ace6149419872029da82463ba rdf:first sg:person.0735145555.75
204 rdf:rest Naa39cf8b02d3406988cc9692243956fc
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biochemistry and Cell Biology
210 rdf:type schema:DefinedTerm
211 sg:journal.1021344 schema:issn 1465-7392
212 1476-4679
213 schema:name Nature Cell Biology
214 rdf:type schema:Periodical
215 sg:person.01054513463.85 schema:familyName Soliman
216 schema:givenName Mohamed A
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054513463.85
218 rdf:type schema:Person
219 sg:person.01114065233.37 schema:familyName Smith
220 schema:givenName Heather
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114065233.37
222 rdf:type schema:Person
223 sg:person.01145732353.17 schema:familyName Rattner
224 schema:givenName Jerome B
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145732353.17
226 rdf:type schema:Person
227 sg:person.01240423151.11 schema:familyName Feng
228 schema:givenName Xiaolan
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240423151.11
230 rdf:type schema:Person
231 sg:person.01340701133.98 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
232 schema:familyName Han
233 schema:givenName Xijing
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340701133.98
235 rdf:type schema:Person
236 sg:person.0607572136.09 schema:familyName Burke
237 schema:givenName Brian E
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607572136.09
239 rdf:type schema:Person
240 sg:person.0626555326.43 schema:familyName Riabowol
241 schema:givenName Karl
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626555326.43
243 rdf:type schema:Person
244 sg:person.0634763317.49 schema:familyName Bose
245 schema:givenName Pinaki
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634763317.49
247 rdf:type schema:Person
248 sg:person.0720557054.76 schema:familyName Scott
249 schema:givenName Michelle S
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720557054.76
251 rdf:type schema:Person
252 sg:person.0735145555.75 schema:familyName Suzuki
253 schema:givenName Keiko
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735145555.75
255 rdf:type schema:Person
256 sg:pub.10.1038/nature01629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533206
257 https://doi.org/10.1038/nature01629
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature04814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023378568
260 https://doi.org/10.1038/nature04814
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature04835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036643627
263 https://doi.org/10.1038/nature04835
264 rdf:type schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1074527852 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1074946766 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1075097673 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1082630920 schema:CreativeWork
269 https://doi.org/10.1002/pmic.200600682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014593973
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.febslet.2006.11.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043260261
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.molcel.2005.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000386876
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.molcel.2006.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012227594
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.tibs.2007.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008959937
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.yexcr.2007.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040594426
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0092-8674(03)00401-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018706213
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.0402943101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003021148
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.0403250101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026766865
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.0602569103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026721109
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.m200197200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025619597
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1083/jcb.131.1.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001020478
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1083/jcb.147.5.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012213633
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1083/jcb.151.6.1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029411876
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/molbev/msh256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053566230
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/j.1474-9726.2008.00393.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048607646
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1128/mcb.00573-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010450745
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/mcb.17.4.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033055864
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/mcb.20.11.3807-3816.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021541738
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1128/mcb.21.8.2918-2932.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005142700
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/mcb.22.3.835-848.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052032823
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1128/mcb.25.15.6639-6648.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028433379
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1136/jcp.56.7.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004289649
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1146/annurev.genom.7.080505.115732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008214167
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1152/physrev.00047.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022291790
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1158/0008-5472.can-05-3444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051757694
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/0008-5472.can-06-3558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044644198
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1242/jcs.01102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036760289
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.22072.35 schema:alternateName University of Calgary
326 schema:name Departments of Biochemistry & Molecular Biology and Oncology, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada.
327 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...