Actin-driven chromosomal motility leads to symmetry breaking in mammalian meiotic oocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

Hongbin Li, Fengli Guo, Boris Rubinstein, Rong Li

ABSTRACT

Movement of meiosis I (MI) chromosomes from the oocyte centre to a subcortical location is the first step in the establishment of cortical polarity. This is required for two consecutive rounds of asymmetric meiotic cell divisions, which generate a mature egg and two polar bodies. Here we use live-cell imaging and genetic and pharmacological manipulations to determine the force-generating mechanism underlying this chromosome movement. Chromosomes were observed to move toward the cortex in a pulsatile manner along a meandering path. This movement is not propelled by myosin-II-driven cortical flow but is associated with a cloud of dynamic actin filaments trailing behind the chromosomes/spindle. Formation of these filaments depends on the actin nucleation activity of Fmn2, a formin-family protein that concentrates around chromosomes through its amino-terminal region. Symmetry breaking of the actin cloud relative to chromosomes, and net chromosome translocation toward the cortex require actin turnover. More... »

PAGES

1301-1308

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1788

DOI

http://dx.doi.org/10.1038/ncb1788

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039463836

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18836438


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