A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08

AUTHORS

Agnieszka Rybak, Heiko Fuchs, Lena Smirnova, Christine Brandt, Elena E Pohl, Robert Nitsch, F Gregory Wulczyn

ABSTRACT

miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7, undergo a marked transition during stem-cell differentiation. Originally identified on the basis of their mutational phenotypes in stem-cell maturation, mir-125 and let-7 are strongly induced during neural differentiation of embryonic stem (ES) cells and embryocarcinoma (EC) cells. We report that embryonic neural stem (NS) cells express let-7 and mir-125, and investigate post-transcriptional mechanisms contributing to the induction of let-7. We demonstrate that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells. In NS cells, Lin-28 is downregulated by mir-125 and let-7, allowing processing of pre-let-7 to proceed. Suppression of let-7 or mir-125 activity in NS cells led to upregulation of Lin-28 and loss of pre-let-7 processing activity, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment. More... »

PAGES

987-993

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1759

DOI

http://dx.doi.org/10.1038/ncb1759

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028865043

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18604195


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feedback, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Processing, Post-Transcriptional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Cell and Neurobiology, Center for Anatomy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rybak", 
        "givenName": "Agnieszka", 
        "id": "sg:person.01067762404.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067762404.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fuchs", 
        "givenName": "Heiko", 
        "id": "sg:person.01056052565.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056052565.14"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Smirnova", 
        "givenName": "Lena", 
        "id": "sg:person.01114510012.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114510012.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Brandt", 
        "givenName": "Christine", 
        "id": "sg:person.0671732636.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671732636.63"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pohl", 
        "givenName": "Elena E", 
        "id": "sg:person.0646223746.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646223746.47"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nitsch", 
        "givenName": "Robert", 
        "id": "sg:person.012764377204.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012764377204.95"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wulczyn", 
        "givenName": "F Gregory", 
        "id": "sg:person.01224722373.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224722373.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1096/fj.06-6130com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002180404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010338150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00809-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012534253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2005.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012643063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.03978.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013567118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.5.10.1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015090693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1554707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015551509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.2006.71.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018814067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018927559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.21.9198-9208.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020519633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1444406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025405827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.5181104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026178540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth1079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028333288", 
          "https://doi.org/10.1038/nmeth1079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029296398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032566675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1616307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034372619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.07.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034464351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m412247200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.2322506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036696023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2007.10.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036919620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90530-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039515219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041493395", 
          "https://doi.org/10.1038/35040556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041493395", 
          "https://doi.org/10.1038/35040556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041702518", 
          "https://doi.org/10.1038/nprot.2006.371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041702518", 
          "https://doi.org/10.1038/nprot.2006.371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042196381", 
          "https://doi.org/10.1038/nature03868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042196381", 
          "https://doi.org/10.1038/nature03868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045076866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045076866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(03)00227-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047428252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35002607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047689840", 
          "https://doi.org/10.1038/35002607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35002607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047689840", 
          "https://doi.org/10.1038/35002607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1151526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048905674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90529-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051619915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(00)00108-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052029364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1154040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.4.1.4364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310356"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08", 
    "datePublishedReg": "2008-08-01", 
    "description": "miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7, undergo a marked transition during stem-cell differentiation. Originally identified on the basis of their mutational phenotypes in stem-cell maturation, mir-125 and let-7 are strongly induced during neural differentiation of embryonic stem (ES) cells and embryocarcinoma (EC) cells. We report that embryonic neural stem (NS) cells express let-7 and mir-125, and investigate post-transcriptional mechanisms contributing to the induction of let-7. We demonstrate that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells. In NS cells, Lin-28 is downregulated by mir-125 and let-7, allowing processing of pre-let-7 to proceed. Suppression of let-7 or mir-125 activity in NS cells led to upregulation of Lin-28 and loss of pre-let-7 processing activity, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb1759", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment", 
    "pagination": "987-993", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8981b381931fea1b99c6083097c0d6325a769609e4c8370353d1acfdf6c7d1b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18604195"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1759"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028865043"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1759", 
      "https://app.dimensions.ai/details/publication/pub.1028865043"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncb/journal/v10/n8/full/ncb1759.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1759'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1759'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1759'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1759'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      72 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1759 schema:about N1105da67bcba426baab483345ec654ce
2 N45e9699e60ad4e8196882b1e725e0f7c
3 N71f2911777194e94a0fcbd8c37a1583e
4 N8732dd3e575e41409bc565d99feb7433
5 N97bf963aa7e946f59e4be374ade92adc
6 Na5439701dc414511832c7ced492126a6
7 Nb01ea070caf542169c2e90d3b9f39f74
8 Nc633d85446ef499db5467810ceead9cf
9 Nd6f3afc9b8f8483b9688b8af395d117e
10 Nde598938f7cf4dd793cf876beef47846
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N1c45f13e0bdf4ecca2688f9c46e06c32
14 schema:citation sg:pub.10.1038/35002607
15 sg:pub.10.1038/35040556
16 sg:pub.10.1038/nature03868
17 sg:pub.10.1038/nmeth1079
18 sg:pub.10.1038/nprot.2006.371
19 https://doi.org/10.1002/dvdy.20712
20 https://doi.org/10.1016/0092-8674(93)90529-y
21 https://doi.org/10.1016/0092-8674(93)90530-4
22 https://doi.org/10.1016/j.cell.2005.01.014
23 https://doi.org/10.1016/j.cell.2005.11.036
24 https://doi.org/10.1016/j.cub.2007.10.058
25 https://doi.org/10.1016/j.gde.2005.12.005
26 https://doi.org/10.1016/j.molcel.2007.07.015
27 https://doi.org/10.1016/j.sbi.2005.05.006
28 https://doi.org/10.1016/s0959-437x(00)00108-8
29 https://doi.org/10.1016/s0960-9822(02)00809-6
30 https://doi.org/10.1016/s1534-5807(03)00227-2
31 https://doi.org/10.1074/jbc.m412247200
32 https://doi.org/10.1096/fj.06-6130com
33 https://doi.org/10.1101/gad.1444406
34 https://doi.org/10.1101/gad.1554707
35 https://doi.org/10.1101/gad.1616307
36 https://doi.org/10.1101/gad.5.10.1825
37 https://doi.org/10.1101/sqb.2006.71.041
38 https://doi.org/10.1111/j.1460-9568.2005.03978.x
39 https://doi.org/10.1126/science.1151526
40 https://doi.org/10.1126/science.1154040
41 https://doi.org/10.1128/mcb.25.21.9198-9208.2005
42 https://doi.org/10.1158/0008-5472.can-07-1083
43 https://doi.org/10.1261/rna.2322506
44 https://doi.org/10.1261/rna.5181104
45 https://doi.org/10.1371/journal.pbio.0030283
46 https://doi.org/10.4161/rna.4.1.4364
47 schema:datePublished 2008-08
48 schema:datePublishedReg 2008-08-01
49 schema:description miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7, undergo a marked transition during stem-cell differentiation. Originally identified on the basis of their mutational phenotypes in stem-cell maturation, mir-125 and let-7 are strongly induced during neural differentiation of embryonic stem (ES) cells and embryocarcinoma (EC) cells. We report that embryonic neural stem (NS) cells express let-7 and mir-125, and investigate post-transcriptional mechanisms contributing to the induction of let-7. We demonstrate that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells. In NS cells, Lin-28 is downregulated by mir-125 and let-7, allowing processing of pre-let-7 to proceed. Suppression of let-7 or mir-125 activity in NS cells led to upregulation of Lin-28 and loss of pre-let-7 processing activity, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N1c68e74e4ae949758ec34d6b1f2c435e
54 N3c59b9ff074f4432972cb3e8894ee84b
55 sg:journal.1021344
56 schema:name A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
57 schema:pagination 987-993
58 schema:productId N00d4afadca554811a642341c9e827c5f
59 N5e94eb26a0584d9c897db1a853b5c658
60 N6193841743fa4b01b40a50188404c001
61 N907703e38b8b4f0f81d9dcbee2e02975
62 Nfbfe114a7bd44904801d2cb31dfa42c5
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028865043
64 https://doi.org/10.1038/ncb1759
65 schema:sdDatePublished 2019-04-10T16:29
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N620d5cc2b26e4095901cb7304efa04f1
68 schema:url http://www.nature.com/ncb/journal/v10/n8/full/ncb1759.html
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N00d4afadca554811a642341c9e827c5f schema:name readcube_id
73 schema:value 8981b381931fea1b99c6083097c0d6325a769609e4c8370353d1acfdf6c7d1b0
74 rdf:type schema:PropertyValue
75 N1105da67bcba426baab483345ec654ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cell Differentiation
77 rdf:type schema:DefinedTerm
78 N1c45f13e0bdf4ecca2688f9c46e06c32 rdf:first sg:person.01067762404.35
79 rdf:rest N455884bda96f48c59035d6589aaff93c
80 N1c68e74e4ae949758ec34d6b1f2c435e schema:volumeNumber 10
81 rdf:type schema:PublicationVolume
82 N3c59b9ff074f4432972cb3e8894ee84b schema:issueNumber 8
83 rdf:type schema:PublicationIssue
84 N455884bda96f48c59035d6589aaff93c rdf:first sg:person.01056052565.14
85 rdf:rest N817433f171854ceea5e05af40ce4e8ff
86 N45e9699e60ad4e8196882b1e725e0f7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Embryonic Stem Cells
88 rdf:type schema:DefinedTerm
89 N5a136ace539b4276805859b47ce13658 rdf:first sg:person.012764377204.95
90 rdf:rest Nde7d4827dd9b4ac99e88cf5b94027d6a
91 N5b793464c762462293b68688db24bfdd rdf:first sg:person.0646223746.47
92 rdf:rest N5a136ace539b4276805859b47ce13658
93 N5e94eb26a0584d9c897db1a853b5c658 schema:name pubmed_id
94 schema:value 18604195
95 rdf:type schema:PropertyValue
96 N6193841743fa4b01b40a50188404c001 schema:name dimensions_id
97 schema:value pub.1028865043
98 rdf:type schema:PropertyValue
99 N620d5cc2b26e4095901cb7304efa04f1 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N71f2911777194e94a0fcbd8c37a1583e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Gene Expression Regulation
103 rdf:type schema:DefinedTerm
104 N817433f171854ceea5e05af40ce4e8ff rdf:first sg:person.01114510012.20
105 rdf:rest N91ee74cf6efe46b0b209aa8aa7122a72
106 N8732dd3e575e41409bc565d99feb7433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Mice
108 rdf:type schema:DefinedTerm
109 N907703e38b8b4f0f81d9dcbee2e02975 schema:name doi
110 schema:value 10.1038/ncb1759
111 rdf:type schema:PropertyValue
112 N91ee74cf6efe46b0b209aa8aa7122a72 rdf:first sg:person.0671732636.63
113 rdf:rest N5b793464c762462293b68688db24bfdd
114 N97bf963aa7e946f59e4be374ade92adc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name RNA-Binding Proteins
116 rdf:type schema:DefinedTerm
117 Na5439701dc414511832c7ced492126a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neurons
119 rdf:type schema:DefinedTerm
120 Nb01ea070caf542169c2e90d3b9f39f74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Feedback, Physiological
122 rdf:type schema:DefinedTerm
123 Nc633d85446ef499db5467810ceead9cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name RNA Processing, Post-Transcriptional
125 rdf:type schema:DefinedTerm
126 Nd6f3afc9b8f8483b9688b8af395d117e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name MicroRNAs
128 rdf:type schema:DefinedTerm
129 Nde598938f7cf4dd793cf876beef47846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 Nde7d4827dd9b4ac99e88cf5b94027d6a rdf:first sg:person.01224722373.43
133 rdf:rest rdf:nil
134 Nfbfe114a7bd44904801d2cb31dfa42c5 schema:name nlm_unique_id
135 schema:value 100890575
136 rdf:type schema:PropertyValue
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biochemistry and Cell Biology
142 rdf:type schema:DefinedTerm
143 sg:journal.1021344 schema:issn 1465-7392
144 1476-4679
145 schema:name Nature Cell Biology
146 rdf:type schema:Periodical
147 sg:person.01056052565.14 schema:familyName Fuchs
148 schema:givenName Heiko
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056052565.14
150 rdf:type schema:Person
151 sg:person.01067762404.35 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
152 schema:familyName Rybak
153 schema:givenName Agnieszka
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067762404.35
155 rdf:type schema:Person
156 sg:person.01114510012.20 schema:familyName Smirnova
157 schema:givenName Lena
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114510012.20
159 rdf:type schema:Person
160 sg:person.01224722373.43 schema:familyName Wulczyn
161 schema:givenName F Gregory
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224722373.43
163 rdf:type schema:Person
164 sg:person.012764377204.95 schema:familyName Nitsch
165 schema:givenName Robert
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012764377204.95
167 rdf:type schema:Person
168 sg:person.0646223746.47 schema:familyName Pohl
169 schema:givenName Elena E
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646223746.47
171 rdf:type schema:Person
172 sg:person.0671732636.63 schema:familyName Brandt
173 schema:givenName Christine
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671732636.63
175 rdf:type schema:Person
176 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
177 https://doi.org/10.1038/35002607
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/35040556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041493395
180 https://doi.org/10.1038/35040556
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/nature03868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042196381
183 https://doi.org/10.1038/nature03868
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nmeth1079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028333288
186 https://doi.org/10.1038/nmeth1079
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/nprot.2006.371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041702518
189 https://doi.org/10.1038/nprot.2006.371
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1002/dvdy.20712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016552497
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0092-8674(93)90529-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619915
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0092-8674(93)90530-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039515219
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.cell.2005.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010338150
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.cell.2005.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032566675
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.cub.2007.10.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036919620
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.gde.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029296398
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.molcel.2007.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034464351
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.sbi.2005.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012643063
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0959-437x(00)00108-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052029364
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0960-9822(02)00809-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012534253
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s1534-5807(03)00227-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047428252
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1074/jbc.m412247200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035780468
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1096/fj.06-6130com schema:sameAs https://app.dimensions.ai/details/publication/pub.1002180404
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1101/gad.1444406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025405827
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1101/gad.1554707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015551509
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1101/gad.1616307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034372619
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1101/gad.5.10.1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015090693
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1101/sqb.2006.71.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018814067
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1460-9568.2005.03978.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013567118
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1126/science.1154040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457451
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1128/mcb.25.21.9198-9208.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020519633
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1158/0008-5472.can-07-1083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018927559
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1261/rna.2322506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036696023
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1261/rna.5181104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026178540
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.pbio.0030283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045076866
244 rdf:type schema:CreativeWork
245 https://doi.org/10.4161/rna.4.1.4364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310356
246 rdf:type schema:CreativeWork
247 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
248 schema:name Institute of Cell and Neurobiology, Center for Anatomy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...