Genomic stability and tumour suppression by the APC/C cofactor Cdh1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06-15

AUTHORS

Irene García-Higuera, Eusebio Manchado, Pierre Dubus, Marta Cañamero, Juan Méndez, Sergio Moreno, Marcos Malumbres

ABSTRACT

The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 specifically promotes protein degradation in late mitosis and G1. Mutant embryos lacking Cdh1 die at E9.5–E10.5 due to defects in the endoreduplication of trophoblast cells and placental malfunction. This lethality is prevented when Cdh1 is expressed in the placenta. Cdh1-deficient cells proliferate inefficiently and accumulate numeric and structural chromosomal aberrations, indicating that Cdh1 contributes to the maintenance of genomic stability. Cdh1 heterozygous animals show increased susceptibility to spontaneous tumours, suggesting that Cdh1 functions as a haploinsufficient tumour suppressor. These heterozygous mice also show several defects in behaviour associated with increased proliferation of stem cells in the nervous system. These results indicate that Cdh1 is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability. More... »

PAGES

802-811

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1742

DOI

http://dx.doi.org/10.1038/ncb1742

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006184899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18552834


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anaphase-Promoting Complex-Cyclosome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behavior, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cdh1 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placenta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligase Complexes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428472.f", 
          "name": [
            "Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
            "Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Higuera", 
        "givenName": "Irene", 
        "id": "sg:person.01160244236.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160244236.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manchado", 
        "givenName": "Eusebio", 
        "id": "sg:person.0732525343.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732525343.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "EA2406 University of Bordeaux 2, Bordeaux, France", 
          "id": "http://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "EA2406 University of Bordeaux 2, Bordeaux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubus", 
        "givenName": "Pierre", 
        "id": "sg:person.01105017171.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105017171.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Comparative Pathology Unit, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Comparative Pathology Unit, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ca\u00f1amero", 
        "givenName": "Marta", 
        "id": "sg:person.0735371677.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735371677.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DNA Replication Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "DNA Replication Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e9ndez", 
        "givenName": "Juan", 
        "id": "sg:person.01360454500.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360454500.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428472.f", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "Sergio", 
        "id": "sg:person.0751766421.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751766421.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malumbres", 
        "givenName": "Marcos", 
        "id": "sg:person.0716321250.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1210703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031199974", 
          "https://doi.org/10.1038/sj.onc.1210703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019108691", 
          "https://doi.org/10.1038/nrm2276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35041694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043172316", 
          "https://doi.org/10.1038/35041694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000525154", 
          "https://doi.org/10.1038/nrm1471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705055", 
          "https://doi.org/10.1038/nrm1988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026732028", 
          "https://doi.org/10.1038/75973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016534738", 
          "https://doi.org/10.1038/ng1861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016208017", 
          "https://doi.org/10.1038/nature02330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031855645", 
          "https://doi.org/10.1038/nprot.2006.205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004970299", 
          "https://doi.org/10.1038/nrm1246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001553347", 
          "https://doi.org/10.1038/nature02381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010844045", 
          "https://doi.org/10.1038/sj.onc.1210578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030229479", 
          "https://doi.org/10.1038/nrc1881"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-06-15", 
    "datePublishedReg": "2008-06-15", 
    "description": "The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C\u2013Cdh1 specifically promotes protein degradation in late mitosis and G1. Mutant embryos lacking Cdh1 die at E9.5\u2013E10.5 due to defects in the endoreduplication of trophoblast cells and placental malfunction. This lethality is prevented when Cdh1 is expressed in the placenta. Cdh1-deficient cells proliferate inefficiently and accumulate numeric and structural chromosomal aberrations, indicating that Cdh1 contributes to the maintenance of genomic stability. Cdh1 heterozygous animals show increased susceptibility to spontaneous tumours, suggesting that Cdh1 functions as a haploinsufficient tumour suppressor. These heterozygous mice also show several defects in behaviour associated with increased proliferation of stem cells in the nervous system. These results indicate that Cdh1 is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncb1742", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "genomic stability", 
      "APC/C cofactor Cdh1", 
      "APC/C", 
      "cell-cycle proteins", 
      "ubiquitin protein ligase", 
      "haploinsufficient tumor suppressor", 
      "specific progenitor cells", 
      "CDH1 function", 
      "mutant embryos", 
      "late mitosis", 
      "mammalian cells", 
      "protein ligase", 
      "genomic instability", 
      "unscheduled proliferation", 
      "protein degradation", 
      "tumor suppression", 
      "tumor suppressor", 
      "CDH1", 
      "heterozygous animals", 
      "stem cells", 
      "progenitor cells", 
      "structural chromosomal aberrations", 
      "chromosomal aberrations", 
      "heterozygous mice", 
      "trophoblast cells", 
      "cells", 
      "cyclosome", 
      "placental malfunction", 
      "Cdc20", 
      "endoreduplication", 
      "anaphase", 
      "proliferation", 
      "E9.5-E10.5", 
      "ligase", 
      "increased susceptibility", 
      "mitosis", 
      "suppressor", 
      "embryos", 
      "nervous system", 
      "protein", 
      "lethality", 
      "degradation", 
      "spontaneous tumors", 
      "G1", 
      "defects", 
      "maintenance", 
      "aberrations", 
      "animals", 
      "mice", 
      "suppression", 
      "susceptibility", 
      "function", 
      "placenta", 
      "stability", 
      "malfunction", 
      "tumors", 
      "results", 
      "instability", 
      "system", 
      "behavior", 
      "Cdh1-deficient cells", 
      "Cdh1 heterozygous animals", 
      "C cofactor Cdh1", 
      "cofactor Cdh1"
    ], 
    "name": "Genomic stability and tumour suppression by the APC/C cofactor Cdh1", 
    "pagination": "802-811", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006184899"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1742"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18552834"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1742", 
      "https://app.dimensions.ai/details/publication/pub.1006184899"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_474.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncb1742"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1742'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1742'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1742'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1742'


 

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      22 PREDICATES      125 URIs      104 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1742 schema:about N0893dd0adc724b9d9d790c46fc80075a
2 N0f00673c8faa4de8addb9f9015f8ef9f
3 N19f06a4b6ba143f7b046939e3965650b
4 N2b7fc62c701a42bf8de4ac91d6ec404e
5 N2f68de480d6e47e381c2a3d2517c0886
6 N35b8c667d1db40ec916e22bbb73c11dc
7 N633004e28c28416581b44d3c5342d792
8 N6466c1da746d474892c16bcf0c9e2f69
9 N7af9afdeac894950801ed2b73998b686
10 N8c031ec7eeb740eebdd81dbfeb3cc387
11 N90dd464b9f2a4a9fbc7537da9a0804ce
12 N9884cd4eb3f34336a020559f6c30b8d8
13 N9de25abe3e404ae3999c85a7da51cf25
14 Na725c3d4d0a44712912961343d434d6c
15 Nb343f061fa194acaad3b6cf1a1e9db6a
16 Nbe4cecd90fa34a5b8af471a633deb7c5
17 Nc95892823339477c85e7b498a840dae8
18 Ncb7ae42b44604291bd72e84d87e5c126
19 Ndd41d4366910405fa142b2a6ca7b3cb4
20 Ne28248daad954464b7bd104ac9d5978a
21 Ne6758a6f7d754ad7a8f91d462e26d4d5
22 Nfef6a30c6d454c56a0fca833da49cf99
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author Nd46aac36e8b34c92beda228ad6c4d161
26 schema:citation sg:pub.10.1038/35041694
27 sg:pub.10.1038/75973
28 sg:pub.10.1038/nature02330
29 sg:pub.10.1038/nature02381
30 sg:pub.10.1038/ng1861
31 sg:pub.10.1038/nprot.2006.205
32 sg:pub.10.1038/nrc1881
33 sg:pub.10.1038/nrm1246
34 sg:pub.10.1038/nrm1471
35 sg:pub.10.1038/nrm1988
36 sg:pub.10.1038/nrm2276
37 sg:pub.10.1038/sj.onc.1210578
38 sg:pub.10.1038/sj.onc.1210703
39 schema:datePublished 2008-06-15
40 schema:datePublishedReg 2008-06-15
41 schema:description The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 specifically promotes protein degradation in late mitosis and G1. Mutant embryos lacking Cdh1 die at E9.5–E10.5 due to defects in the endoreduplication of trophoblast cells and placental malfunction. This lethality is prevented when Cdh1 is expressed in the placenta. Cdh1-deficient cells proliferate inefficiently and accumulate numeric and structural chromosomal aberrations, indicating that Cdh1 contributes to the maintenance of genomic stability. Cdh1 heterozygous animals show increased susceptibility to spontaneous tumours, suggesting that Cdh1 functions as a haploinsufficient tumour suppressor. These heterozygous mice also show several defects in behaviour associated with increased proliferation of stem cells in the nervous system. These results indicate that Cdh1 is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability.
42 schema:genre article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N1b4fd3691f6a4be48e2d352e06fc2e3e
46 N42fd87973e2b46bea15ba6b2b0592c63
47 sg:journal.1021344
48 schema:keywords APC/C
49 APC/C cofactor Cdh1
50 C cofactor Cdh1
51 CDH1
52 CDH1 function
53 Cdc20
54 Cdh1 heterozygous animals
55 Cdh1-deficient cells
56 E9.5-E10.5
57 G1
58 aberrations
59 anaphase
60 animals
61 behavior
62 cell-cycle proteins
63 cells
64 chromosomal aberrations
65 cofactor Cdh1
66 cyclosome
67 defects
68 degradation
69 embryos
70 endoreduplication
71 function
72 genomic instability
73 genomic stability
74 haploinsufficient tumor suppressor
75 heterozygous animals
76 heterozygous mice
77 increased susceptibility
78 instability
79 late mitosis
80 lethality
81 ligase
82 maintenance
83 malfunction
84 mammalian cells
85 mice
86 mitosis
87 mutant embryos
88 nervous system
89 placenta
90 placental malfunction
91 progenitor cells
92 proliferation
93 protein
94 protein degradation
95 protein ligase
96 results
97 specific progenitor cells
98 spontaneous tumors
99 stability
100 stem cells
101 structural chromosomal aberrations
102 suppression
103 suppressor
104 susceptibility
105 system
106 trophoblast cells
107 tumor suppression
108 tumor suppressor
109 tumors
110 ubiquitin protein ligase
111 unscheduled proliferation
112 schema:name Genomic stability and tumour suppression by the APC/C cofactor Cdh1
113 schema:pagination 802-811
114 schema:productId N21074734ac6c4fb8af73606aeb787a3b
115 N786eaad7d5af49138761752b4e542eb3
116 N95865d66c97d4097a5c42200cf1dde81
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184899
118 https://doi.org/10.1038/ncb1742
119 schema:sdDatePublished 2021-12-01T19:21
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N51961ee46691459ebedfee90d5f2828b
122 schema:url https://doi.org/10.1038/ncb1742
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N0893dd0adc724b9d9d790c46fc80075a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Brain
128 rdf:type schema:DefinedTerm
129 N0f00673c8faa4de8addb9f9015f8ef9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Chromosome Aberrations
131 rdf:type schema:DefinedTerm
132 N19f06a4b6ba143f7b046939e3965650b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Pregnancy
134 rdf:type schema:DefinedTerm
135 N1b00efcbcaec4070820537c255c7c2b3 rdf:first sg:person.0735371677.41
136 rdf:rest N9a72229583ab4267937de21510d070f2
137 N1b4fd3691f6a4be48e2d352e06fc2e3e schema:issueNumber 7
138 rdf:type schema:PublicationIssue
139 N1ff45adde39a43a68d993efa5a0d2fbc rdf:first sg:person.0732525343.22
140 rdf:rest Ne5d99dfd59ed43be9b74aa76dbd6ed07
141 N21074734ac6c4fb8af73606aeb787a3b schema:name pubmed_id
142 schema:value 18552834
143 rdf:type schema:PropertyValue
144 N2b7fc62c701a42bf8de4ac91d6ec404e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ubiquitin-Protein Ligase Complexes
146 rdf:type schema:DefinedTerm
147 N2f68de480d6e47e381c2a3d2517c0886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Cycle Proteins
149 rdf:type schema:DefinedTerm
150 N35b8c667d1db40ec916e22bbb73c11dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Tumor Suppressor Proteins
152 rdf:type schema:DefinedTerm
153 N3bfd16a7db6b48d7ba011d64cf4e5de7 rdf:first sg:person.0751766421.38
154 rdf:rest Nc83d549441674719aad1591d0aedfaca
155 N42fd87973e2b46bea15ba6b2b0592c63 schema:volumeNumber 10
156 rdf:type schema:PublicationVolume
157 N51961ee46691459ebedfee90d5f2828b schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N633004e28c28416581b44d3c5342d792 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Placenta
161 rdf:type schema:DefinedTerm
162 N6466c1da746d474892c16bcf0c9e2f69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cell Proliferation
164 rdf:type schema:DefinedTerm
165 N786eaad7d5af49138761752b4e542eb3 schema:name dimensions_id
166 schema:value pub.1006184899
167 rdf:type schema:PropertyValue
168 N7af9afdeac894950801ed2b73998b686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Genomic Instability
170 rdf:type schema:DefinedTerm
171 N8c031ec7eeb740eebdd81dbfeb3cc387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 N90dd464b9f2a4a9fbc7537da9a0804ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cells, Cultured
176 rdf:type schema:DefinedTerm
177 N95865d66c97d4097a5c42200cf1dde81 schema:name doi
178 schema:value 10.1038/ncb1742
179 rdf:type schema:PropertyValue
180 N9884cd4eb3f34336a020559f6c30b8d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Embryo, Mammalian
182 rdf:type schema:DefinedTerm
183 N9a72229583ab4267937de21510d070f2 rdf:first sg:person.01360454500.79
184 rdf:rest N3bfd16a7db6b48d7ba011d64cf4e5de7
185 N9de25abe3e404ae3999c85a7da51cf25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Neoplasms
187 rdf:type schema:DefinedTerm
188 Na725c3d4d0a44712912961343d434d6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Cycle
190 rdf:type schema:DefinedTerm
191 Nb343f061fa194acaad3b6cf1a1e9db6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Behavior, Animal
193 rdf:type schema:DefinedTerm
194 Nbe4cecd90fa34a5b8af471a633deb7c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Mice, Transgenic
196 rdf:type schema:DefinedTerm
197 Nc83d549441674719aad1591d0aedfaca rdf:first sg:person.0716321250.19
198 rdf:rest rdf:nil
199 Nc95892823339477c85e7b498a840dae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Anaphase-Promoting Complex-Cyclosome
201 rdf:type schema:DefinedTerm
202 Ncb7ae42b44604291bd72e84d87e5c126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice, Knockout
204 rdf:type schema:DefinedTerm
205 Nd46aac36e8b34c92beda228ad6c4d161 rdf:first sg:person.01160244236.13
206 rdf:rest N1ff45adde39a43a68d993efa5a0d2fbc
207 Ndd41d4366910405fa142b2a6ca7b3cb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Animals
209 rdf:type schema:DefinedTerm
210 Ne28248daad954464b7bd104ac9d5978a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Mice
212 rdf:type schema:DefinedTerm
213 Ne5d99dfd59ed43be9b74aa76dbd6ed07 rdf:first sg:person.01105017171.35
214 rdf:rest N1b00efcbcaec4070820537c255c7c2b3
215 Ne6758a6f7d754ad7a8f91d462e26d4d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Cdh1 Proteins
217 rdf:type schema:DefinedTerm
218 Nfef6a30c6d454c56a0fca833da49cf99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Fibroblasts
220 rdf:type schema:DefinedTerm
221 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
222 schema:name Biological Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
225 schema:name Biochemistry and Cell Biology
226 rdf:type schema:DefinedTerm
227 sg:journal.1021344 schema:issn 1465-7392
228 1476-4679
229 schema:name Nature Cell Biology
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01105017171.35 schema:affiliation grid-institutes:grid.412041.2
233 schema:familyName Dubus
234 schema:givenName Pierre
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105017171.35
236 rdf:type schema:Person
237 sg:person.01160244236.13 schema:affiliation grid-institutes:grid.428472.f
238 schema:familyName García-Higuera
239 schema:givenName Irene
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160244236.13
241 rdf:type schema:Person
242 sg:person.01360454500.79 schema:affiliation grid-institutes:grid.7719.8
243 schema:familyName Méndez
244 schema:givenName Juan
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360454500.79
246 rdf:type schema:Person
247 sg:person.0716321250.19 schema:affiliation grid-institutes:grid.7719.8
248 schema:familyName Malumbres
249 schema:givenName Marcos
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19
251 rdf:type schema:Person
252 sg:person.0732525343.22 schema:affiliation grid-institutes:grid.7719.8
253 schema:familyName Manchado
254 schema:givenName Eusebio
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732525343.22
256 rdf:type schema:Person
257 sg:person.0735371677.41 schema:affiliation grid-institutes:grid.7719.8
258 schema:familyName Cañamero
259 schema:givenName Marta
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735371677.41
261 rdf:type schema:Person
262 sg:person.0751766421.38 schema:affiliation grid-institutes:grid.428472.f
263 schema:familyName Moreno
264 schema:givenName Sergio
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751766421.38
266 rdf:type schema:Person
267 sg:pub.10.1038/35041694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043172316
268 https://doi.org/10.1038/35041694
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/75973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026732028
271 https://doi.org/10.1038/75973
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nature02330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016208017
274 https://doi.org/10.1038/nature02330
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nature02381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001553347
277 https://doi.org/10.1038/nature02381
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ng1861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534738
280 https://doi.org/10.1038/ng1861
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nprot.2006.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031855645
283 https://doi.org/10.1038/nprot.2006.205
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nrc1881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030229479
286 https://doi.org/10.1038/nrc1881
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nrm1246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004970299
289 https://doi.org/10.1038/nrm1246
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrm1471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000525154
292 https://doi.org/10.1038/nrm1471
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrm1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705055
295 https://doi.org/10.1038/nrm1988
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nrm2276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019108691
298 https://doi.org/10.1038/nrm2276
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/sj.onc.1210578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010844045
301 https://doi.org/10.1038/sj.onc.1210578
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/sj.onc.1210703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031199974
304 https://doi.org/10.1038/sj.onc.1210703
305 rdf:type schema:CreativeWork
306 grid-institutes:grid.412041.2 schema:alternateName EA2406 University of Bordeaux 2, Bordeaux, France
307 schema:name EA2406 University of Bordeaux 2, Bordeaux, France
308 rdf:type schema:Organization
309 grid-institutes:grid.428472.f schema:alternateName Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain
310 schema:name Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
311 Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain
312 rdf:type schema:Organization
313 grid-institutes:grid.7719.8 schema:alternateName Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
314 Comparative Pathology Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
315 DNA Replication Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
316 schema:name Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
317 Comparative Pathology Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
318 DNA Replication Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
319 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...