Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-02-10

AUTHORS

Tomoya Kitamura, Naoya Asai, Atsushi Enomoto, Kengo Maeda, Takuya Kato, Maki Ishida, Ping Jiang, Takashi Watanabe, Jiro Usukura, Takahisa Kondo, Frank Costantini, Toyoaki Murohara, Masahide Takahashi

ABSTRACT

The serine/threonine protein kinase Akt is involved in a variety of cellular processes including cell proliferation, survival, metabolism and gene expression. It is essential in vascular endothelial growth factor (VEGF)-mediated angiogenesis; however, it is not known how Akt regulates the migration of endothelial cells, a crucial process for vessel sprouting, branching and the formation of networks during angiogenesis. Here we report that Akt-mediated phosphorylation of Girdin, an actin-binding protein, promotes VEGF-dependent migration of endothelial cells and tube formation by these cells. We found that exogenously delivered adenovirus harbouring Girdin short interfering RNA in Matrigel embedded in mice, markedly inhibited VEGF-mediated angiogenesis. Targeted disruption of the Girdin gene in mice impaired vessel remodelling in the retina and angiogenesis from aortic rings, whereas Girdin was dispensable for embryonic vasculogenesis. These findings demonstrate that the Akt/Girdin signalling pathway is essential in VEGF-mediated postneonatal angiogenesis. More... »

PAGES

329-337

Journal

TITLE

Nature Cell Biology

ISSUE

3

VOLUME

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1695

DOI

http://dx.doi.org/10.1038/ncb1695

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033239493

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18264090


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64 mice
65 migration
66 network
67 pathway
68 phosphorylation
69 phosphorylation of Girdin
70 process
71 proliferation
72 protein
73 protein kinase Akt
74 regulation
75 regulation of VEGF
76 retina
77 ring
78 serine/threonine protein kinase Akt
79 sprouting
80 survival
81 targeted disruption
82 tube formation
83 variety
84 vascular endothelial growth factor
85 vasculogenesis
86 vessel sprouting
87 vessels
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