Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-05

AUTHORS

Christopher P Baines, Robert A Kaiser, Tatiana Sheiko, William J Craigen, Jeffery D Molkentin

ABSTRACT

Mitochondria are critically involved in necrotic cell death induced by Ca(2+) overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore - a protein complex that spans both the outer and inner mitochondrial membranes - is considered the mediator of this event and has been hypothesized to minimally consist of the voltage-dependent anion channel (Vdac) in the outer membrane, the adenine-nucleotide translocase (Ant) in the inner membrane and cyclophilin-D in the matrix. Here, we report the effects of deletion of the three mammalian Vdac genes on mitochondrial-dependent cell death. Mitochondria from Vdac1-, Vdac3-, and Vdac1-Vdac3-null mice exhibited a Ca(2+)- and oxidative stress-induced MPT that was indistinguishable from wild-type mitochondria. Similarly, Ca(2+)- and oxidative-stress-induced MPT and cell death was unaltered, or even exacerbated, in fibroblasts lacking Vdac1, Vdac2, Vdac3, Vdac1-Vdac3 and Vdac1-Vdac2-Vdac3. Wild-type and Vdac-deficient mitochondria and cells also exhibited equivalent cytochrome c release, caspase cleavage and cell death in response to the pro-death Bcl-2 family members Bax and Bid. These results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death. More... »

PAGES

550-555

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1575

DOI

http://dx.doi.org/10.1038/ncb1575

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031431852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17417626


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophilins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochromes c", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria, Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria, Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial ADP, ATP Translocases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Membranes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Swelling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Voltage-Dependent Anion Channel 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Voltage-Dependent Anion Channel 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Voltage-Dependent Anion Channels", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baines", 
        "givenName": "Christopher P", 
        "id": "sg:person.01104726560.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104726560.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kaiser", 
        "givenName": "Robert A", 
        "id": "sg:person.0651453426.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651453426.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sheiko", 
        "givenName": "Tatiana", 
        "id": "sg:person.01222043112.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222043112.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Craigen", 
        "givenName": "William J", 
        "id": "sg:person.014214035344.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214035344.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Molkentin", 
        "givenName": "Jeffery D", 
        "id": "sg:person.010551517577.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010551517577.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000156171", 
          "https://doi.org/10.1038/sj.onc.1205621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000156171", 
          "https://doi.org/10.1038/sj.onc.1205621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.16.12321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000392735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.090082297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002001619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304748200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003321776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003832106", 
          "https://doi.org/10.1038/nature03434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003832106", 
          "https://doi.org/10.1038/nature03434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505294102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006237796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505294102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006237796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00046-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009019174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009134673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009134673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m104724200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010999318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010999799", 
          "https://doi.org/10.1038/sj.onc.1207205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010999799", 
          "https://doi.org/10.1038/sj.onc.1207205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(99)77239-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011120529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0602217103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011956923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c500089200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016557762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15216540152845902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020053468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022933989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022933989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m201649200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024188250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3360287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024430936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3360287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024430936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025255831", 
          "https://doi.org/10.1038/sj.gt.3301048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025255831", 
          "https://doi.org/10.1038/sj.gt.3301048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbabio.2006.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028740928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9084(02)01375-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029813579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m313717200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030283228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m006587200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031410907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10863-005-6566-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031518875", 
          "https://doi.org/10.1007/s10863-005-6566-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10863-005-6566-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031518875", 
          "https://doi.org/10.1007/s10863-005-6566-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031543955", 
          "https://doi.org/10.1038/nature02229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031543955", 
          "https://doi.org/10.1038/nature02229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/20959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031691936", 
          "https://doi.org/10.1038/20959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/20959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031691936", 
          "https://doi.org/10.1038/20959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1999.00198.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032337070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9084(02)01368-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033642223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1998.2580729.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037834718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m101590200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038313038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2004.08.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038855827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4889(99)00120-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042377998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050952027", 
          "https://doi.org/10.1038/nature03317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050952027", 
          "https://doi.org/10.1038/nature03317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2006.05213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052290049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35048073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053037482", 
          "https://doi.org/10.1038/35048073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35048073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053037482", 
          "https://doi.org/10.1038/35048073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m310593200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053061997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3450271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056714460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20060232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1083995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448061"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-05", 
    "datePublishedReg": "2007-05-01", 
    "description": "Mitochondria are critically involved in necrotic cell death induced by Ca(2+) overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore - a protein complex that spans both the outer and inner mitochondrial membranes - is considered the mediator of this event and has been hypothesized to minimally consist of the voltage-dependent anion channel (Vdac) in the outer membrane, the adenine-nucleotide translocase (Ant) in the inner membrane and cyclophilin-D in the matrix. Here, we report the effects of deletion of the three mammalian Vdac genes on mitochondrial-dependent cell death. Mitochondria from Vdac1-, Vdac3-, and Vdac1-Vdac3-null mice exhibited a Ca(2+)- and oxidative stress-induced MPT that was indistinguishable from wild-type mitochondria. Similarly, Ca(2+)- and oxidative-stress-induced MPT and cell death was unaltered, or even exacerbated, in fibroblasts lacking Vdac1, Vdac2, Vdac3, Vdac1-Vdac3 and Vdac1-Vdac2-Vdac3. Wild-type and Vdac-deficient mitochondria and cells also exhibited equivalent cytochrome c release, caspase cleavage and cell death in response to the pro-death Bcl-2 family members Bax and Bid. These results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb1575", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2536383", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440800", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2536948", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2540531", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2436975", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death", 
    "pagination": "550-555", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95bc06986dc2454e90599cfac41f904c40d2d1867521337464fc3a58ab468cb1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17417626"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1575"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031431852"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1575", 
      "https://app.dimensions.ai/details/publication/pub.1031431852"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71701_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncb/journal/v9/n5/full/ncb1575.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1575'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1575'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1575'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1575'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      94 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1575 schema:about N040210ebc4bb4506bc8d9a6003c5a496
2 N16a7082ae9c342648f9176f2ab497ed7
3 N18a943258a8840b681dc6ea7b9afb750
4 N1dc4931e5e3a41e7a25066dc4770f378
5 N3810ea6c41e94f2f9a06be93afebf59c
6 N41e62f75f2054baab6e274728d5d5152
7 N4c921aeb67444dc48ce8aa370721b40c
8 N5b633a0bd6664713a9890cc9c6abe807
9 N5e0aedc5c7a74c6bbff3a305d0a9752d
10 N68392face37f487d8ab4c18780343ea4
11 N6e02c910c4c641f9a61261e49bcbe3f2
12 N7de649c40856496b9caffd381d3d3cd1
13 N8c22b9ce6fa84856a40df26f92dd481e
14 N9115fabb94ce4e07a43a68f6e85df705
15 N9b51a5b5b67840f4b9798275022aeaaa
16 Na3aa7326e45d4b7b9e2eda888cd05584
17 Nb96404613242492e8e93733f3994a8a1
18 Nbdb1e187241240d2b8fda62eb2767e09
19 Nc2480162069141ef84a4b02ba9a66e16
20 Nc4ba446527fb499ea5d0e79ae6c9c890
21 Ncbeef58cb06a4139a5d0990b3464afec
22 Nce18c20bfc3243eeb6385816aa4181ce
23 Nd5dab2aad8f1457498f61b8b653ba61c
24 Nde9e929c39864398b84fb18ec96935cb
25 Ne8fa79f526fd4f2a9ca71bdf750304cc
26 Nf3e8eb9f65564b1e86b52045a473a386
27 Nfe7c502190f94c7ab27582e4e2869f99
28 anzsrc-for:06
29 anzsrc-for:0601
30 schema:author N46c13a56b7724c149ffec5d3eb3aded7
31 schema:citation sg:pub.10.1007/s10863-005-6566-8
32 sg:pub.10.1038/20959
33 sg:pub.10.1038/35048073
34 sg:pub.10.1038/nature02229
35 sg:pub.10.1038/nature03317
36 sg:pub.10.1038/nature03434
37 sg:pub.10.1038/sj.gt.3301048
38 sg:pub.10.1038/sj.onc.1205621
39 sg:pub.10.1038/sj.onc.1207205
40 https://doi.org/10.1016/j.bbabio.2006.02.007
41 https://doi.org/10.1016/j.bbrc.2004.08.094
42 https://doi.org/10.1016/s0006-3495(99)77239-5
43 https://doi.org/10.1016/s0092-8674(04)00046-7
44 https://doi.org/10.1016/s0167-4889(99)00120-2
45 https://doi.org/10.1016/s0300-9084(02)01368-8
46 https://doi.org/10.1016/s0300-9084(02)01375-5
47 https://doi.org/10.1042/0264-6021:3450271
48 https://doi.org/10.1042/bj20030690
49 https://doi.org/10.1042/bj3360287
50 https://doi.org/10.1042/bst0340232
51 https://doi.org/10.1042/bst20060232
52 https://doi.org/10.1046/j.1432-1327.1998.2580729.x
53 https://doi.org/10.1046/j.1432-1327.1999.00198.x
54 https://doi.org/10.1073/pnas.0505294102
55 https://doi.org/10.1073/pnas.0602217103
56 https://doi.org/10.1073/pnas.090082297
57 https://doi.org/10.1074/jbc.275.16.12321
58 https://doi.org/10.1074/jbc.c500089200
59 https://doi.org/10.1074/jbc.m006587200
60 https://doi.org/10.1074/jbc.m101590200
61 https://doi.org/10.1074/jbc.m104724200
62 https://doi.org/10.1074/jbc.m201649200
63 https://doi.org/10.1074/jbc.m304748200
64 https://doi.org/10.1074/jbc.m310593200
65 https://doi.org/10.1074/jbc.m313717200
66 https://doi.org/10.1080/15216540152845902
67 https://doi.org/10.1111/j.1742-4658.2006.05213.x
68 https://doi.org/10.1126/science.1083995
69 schema:datePublished 2007-05
70 schema:datePublishedReg 2007-05-01
71 schema:description Mitochondria are critically involved in necrotic cell death induced by Ca(2+) overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore - a protein complex that spans both the outer and inner mitochondrial membranes - is considered the mediator of this event and has been hypothesized to minimally consist of the voltage-dependent anion channel (Vdac) in the outer membrane, the adenine-nucleotide translocase (Ant) in the inner membrane and cyclophilin-D in the matrix. Here, we report the effects of deletion of the three mammalian Vdac genes on mitochondrial-dependent cell death. Mitochondria from Vdac1-, Vdac3-, and Vdac1-Vdac3-null mice exhibited a Ca(2+)- and oxidative stress-induced MPT that was indistinguishable from wild-type mitochondria. Similarly, Ca(2+)- and oxidative-stress-induced MPT and cell death was unaltered, or even exacerbated, in fibroblasts lacking Vdac1, Vdac2, Vdac3, Vdac1-Vdac3 and Vdac1-Vdac2-Vdac3. Wild-type and Vdac-deficient mitochondria and cells also exhibited equivalent cytochrome c release, caspase cleavage and cell death in response to the pro-death Bcl-2 family members Bax and Bid. These results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N86d9d1f9df6a4ac3b1a2788431bb1f05
76 Nc94cea12b38d4d06b5d6d4d7ebec4280
77 sg:journal.1021344
78 schema:name Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
79 schema:pagination 550-555
80 schema:productId N1fbd77d18262403b97a2e9c85a652bf1
81 N5ae797d654ec43d090eea6889f7623f5
82 N6b6e8e6215494d9b88dff4203822f1cf
83 Nfe282ec30232493da5348bc920b04021
84 Nffeac800a8654abf8ff27deeea786025
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031431852
86 https://doi.org/10.1038/ncb1575
87 schema:sdDatePublished 2019-04-11T13:00
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N232f1307723644898a1f427c5e8ea444
90 schema:url http://www.nature.com/ncb/journal/v9/n5/full/ncb1575.html
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N040210ebc4bb4506bc8d9a6003c5a496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Mitochondrial ADP, ATP Translocases
96 rdf:type schema:DefinedTerm
97 N16a7082ae9c342648f9176f2ab497ed7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Mice, Knockout
99 rdf:type schema:DefinedTerm
100 N18a943258a8840b681dc6ea7b9afb750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Calcium
102 rdf:type schema:DefinedTerm
103 N1dc4931e5e3a41e7a25066dc4770f378 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Voltage-Dependent Anion Channel 2
105 rdf:type schema:DefinedTerm
106 N1fbd77d18262403b97a2e9c85a652bf1 schema:name pubmed_id
107 schema:value 17417626
108 rdf:type schema:PropertyValue
109 N232f1307723644898a1f427c5e8ea444 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N3810ea6c41e94f2f9a06be93afebf59c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Apoptosis
113 rdf:type schema:DefinedTerm
114 N41e62f75f2054baab6e274728d5d5152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Voltage-Dependent Anion Channels
116 rdf:type schema:DefinedTerm
117 N46c13a56b7724c149ffec5d3eb3aded7 rdf:first sg:person.01104726560.26
118 rdf:rest Nfdd7a02488c14b36bd0cd6858431f79b
119 N4c921aeb67444dc48ce8aa370721b40c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mitochondria, Heart
121 rdf:type schema:DefinedTerm
122 N5ae797d654ec43d090eea6889f7623f5 schema:name readcube_id
123 schema:value 95bc06986dc2454e90599cfac41f904c40d2d1867521337464fc3a58ab468cb1
124 rdf:type schema:PropertyValue
125 N5b633a0bd6664713a9890cc9c6abe807 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cytochromes c
127 rdf:type schema:DefinedTerm
128 N5e0aedc5c7a74c6bbff3a305d0a9752d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Oxidative Stress
130 rdf:type schema:DefinedTerm
131 N68392face37f487d8ab4c18780343ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mitochondrial Proteins
133 rdf:type schema:DefinedTerm
134 N69f54b0afce74421a46127942fb844ca rdf:first sg:person.010551517577.00
135 rdf:rest rdf:nil
136 N6b6e8e6215494d9b88dff4203822f1cf schema:name dimensions_id
137 schema:value pub.1031431852
138 rdf:type schema:PropertyValue
139 N6e02c910c4c641f9a61261e49bcbe3f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Membrane Permeability
141 rdf:type schema:DefinedTerm
142 N74aabb2191354753af1162518d8befd5 rdf:first sg:person.01222043112.21
143 rdf:rest N93cb3e7474c449fbaa9ba72da198dde0
144 N7de649c40856496b9caffd381d3d3cd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name RNA Interference
146 rdf:type schema:DefinedTerm
147 N86d9d1f9df6a4ac3b1a2788431bb1f05 schema:issueNumber 5
148 rdf:type schema:PublicationIssue
149 N8c22b9ce6fa84856a40df26f92dd481e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Transfection
151 rdf:type schema:DefinedTerm
152 N9115fabb94ce4e07a43a68f6e85df705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Death
154 rdf:type schema:DefinedTerm
155 N93cb3e7474c449fbaa9ba72da198dde0 rdf:first sg:person.014214035344.00
156 rdf:rest N69f54b0afce74421a46127942fb844ca
157 N9b51a5b5b67840f4b9798275022aeaaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Voltage-Dependent Anion Channel 1
159 rdf:type schema:DefinedTerm
160 Na3aa7326e45d4b7b9e2eda888cd05584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Proto-Oncogene Proteins c-bcl-2
162 rdf:type schema:DefinedTerm
163 Na5885aac3563460f9dc1aaabfe46f75e schema:name Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
164 rdf:type schema:Organization
165 Nb96404613242492e8e93733f3994a8a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mitochondrial Swelling
167 rdf:type schema:DefinedTerm
168 Nbdb1e187241240d2b8fda62eb2767e09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cyclophilins
170 rdf:type schema:DefinedTerm
171 Nc2480162069141ef84a4b02ba9a66e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Mitochondrial Membrane Transport Proteins
173 rdf:type schema:DefinedTerm
174 Nc4ba446527fb499ea5d0e79ae6c9c890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mitochondrial Membranes
176 rdf:type schema:DefinedTerm
177 Nc94cea12b38d4d06b5d6d4d7ebec4280 schema:volumeNumber 9
178 rdf:type schema:PublicationVolume
179 Ncbeef58cb06a4139a5d0990b3464afec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Mice
181 rdf:type schema:DefinedTerm
182 Nce18c20bfc3243eeb6385816aa4181ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Time Factors
184 rdf:type schema:DefinedTerm
185 Nd5dab2aad8f1457498f61b8b653ba61c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Animals
187 rdf:type schema:DefinedTerm
188 Nde9e929c39864398b84fb18ec96935cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name RNA, Small Interfering
190 rdf:type schema:DefinedTerm
191 Ne8fa79f526fd4f2a9ca71bdf750304cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Mitochondria, Liver
193 rdf:type schema:DefinedTerm
194 Nf3e8eb9f65564b1e86b52045a473a386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Caspases
196 rdf:type schema:DefinedTerm
197 Nfdd7a02488c14b36bd0cd6858431f79b rdf:first sg:person.0651453426.39
198 rdf:rest N74aabb2191354753af1162518d8befd5
199 Nfe282ec30232493da5348bc920b04021 schema:name nlm_unique_id
200 schema:value 100890575
201 rdf:type schema:PropertyValue
202 Nfe7c502190f94c7ab27582e4e2869f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cells, Cultured
204 rdf:type schema:DefinedTerm
205 Nffeac800a8654abf8ff27deeea786025 schema:name doi
206 schema:value 10.1038/ncb1575
207 rdf:type schema:PropertyValue
208 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biological Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biochemistry and Cell Biology
213 rdf:type schema:DefinedTerm
214 sg:grant.2436975 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1575
215 rdf:type schema:MonetaryGrant
216 sg:grant.2440800 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1575
217 rdf:type schema:MonetaryGrant
218 sg:grant.2536383 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1575
219 rdf:type schema:MonetaryGrant
220 sg:grant.2536948 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1575
221 rdf:type schema:MonetaryGrant
222 sg:grant.2540531 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1575
223 rdf:type schema:MonetaryGrant
224 sg:journal.1021344 schema:issn 1465-7392
225 1476-4679
226 schema:name Nature Cell Biology
227 rdf:type schema:Periodical
228 sg:person.010551517577.00 schema:familyName Molkentin
229 schema:givenName Jeffery D
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010551517577.00
231 rdf:type schema:Person
232 sg:person.01104726560.26 schema:affiliation Na5885aac3563460f9dc1aaabfe46f75e
233 schema:familyName Baines
234 schema:givenName Christopher P
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104726560.26
236 rdf:type schema:Person
237 sg:person.01222043112.21 schema:familyName Sheiko
238 schema:givenName Tatiana
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222043112.21
240 rdf:type schema:Person
241 sg:person.014214035344.00 schema:familyName Craigen
242 schema:givenName William J
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214035344.00
244 rdf:type schema:Person
245 sg:person.0651453426.39 schema:familyName Kaiser
246 schema:givenName Robert A
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651453426.39
248 rdf:type schema:Person
249 sg:pub.10.1007/s10863-005-6566-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031518875
250 https://doi.org/10.1007/s10863-005-6566-8
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/20959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031691936
253 https://doi.org/10.1038/20959
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/35048073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053037482
256 https://doi.org/10.1038/35048073
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature02229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031543955
259 https://doi.org/10.1038/nature02229
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature03317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050952027
262 https://doi.org/10.1038/nature03317
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nature03434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003832106
265 https://doi.org/10.1038/nature03434
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/sj.gt.3301048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025255831
268 https://doi.org/10.1038/sj.gt.3301048
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/sj.onc.1205621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000156171
271 https://doi.org/10.1038/sj.onc.1205621
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/sj.onc.1207205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010999799
274 https://doi.org/10.1038/sj.onc.1207205
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.bbabio.2006.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028740928
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.bbrc.2004.08.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038855827
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0006-3495(99)77239-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011120529
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s0092-8674(04)00046-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009019174
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0167-4889(99)00120-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042377998
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0300-9084(02)01368-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033642223
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0300-9084(02)01375-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813579
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1042/0264-6021:3450271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714460
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1042/bj20030690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009134673
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1042/bj3360287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024430936
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1042/bst0340232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022933989
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1042/bst20060232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717499
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1046/j.1432-1327.1998.2580729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037834718
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1046/j.1432-1327.1999.00198.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032337070
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1073/pnas.0505294102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006237796
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1073/pnas.0602217103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011956923
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1073/pnas.090082297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002001619
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1074/jbc.275.16.12321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000392735
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.c500089200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016557762
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1074/jbc.m006587200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031410907
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1074/jbc.m101590200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038313038
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1074/jbc.m104724200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010999318
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1074/jbc.m201649200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024188250
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1074/jbc.m304748200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003321776
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1074/jbc.m310593200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053061997
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1074/jbc.m313717200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030283228
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1080/15216540152845902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020053468
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1111/j.1742-4658.2006.05213.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052290049
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1126/science.1083995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448061
333 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...