Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-07

AUTHORS

Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig, André Nussenzweig

ABSTRACT

Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (Atm) in response to ionizing radiation, whereas ataxia-telangiectasia- and Rad3-related (Atr)-dependent signalling and Atm activation in response to ultraviolet light, inhibitors of DNA replication, or hypotonic stress are intact. Expression of the main human NBS allele rescues the lethality of Nbs1-/- mice, but leads to immunodeficiency, cancer predisposition, a defect in meiotic progression in females and cell-cycle checkpoint defects that are associated with a partial reduction in Atm activity. The Mre11 interaction domain of Nbs1 is essential for viability, whereas the Forkhead-associated (FHA) domain is required for T-cell and oocyte development and efficient DNA damage signalling. Reconstitution of Nbs1 knockout mice with various mutant isoforms demonstrates the biological impact of impaired Nbs1 function at the cellular and organismal level. More... »

PAGES

675-685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1270

DOI

http://dx.doi.org/10.1038/ncb1270

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025699748

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15965469


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP-Binding Cassette Transporters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ataxia Telangiectasia Mutated Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Breakage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gonads", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Class Switching", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Non-Hodgkin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MRE11 Homologue Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Difilippantonio", 
        "givenName": "Simone", 
        "id": "sg:person.0773142751.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773142751.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Celeste", 
        "givenName": "Arkady", 
        "id": "sg:person.01034630345.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034630345.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez-Capetillo", 
        "givenName": "Oscar", 
        "id": "sg:person.01107263432.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263432.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hua-Tang", 
        "id": "sg:person.0605734250.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605734250.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rockefeller University", 
          "id": "https://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "San Martin", 
        "givenName": "Bernardo Reina", 
        "id": "sg:person.015511120215.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015511120215.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Laethem", 
        "givenName": "Francois", 
        "id": "sg:person.01326444625.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326444625.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Mouse Cancer Genetics Program, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Yong-Ping", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Diabetes and Digestive and Kidney Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419635.c", 
          "name": [
            "Genetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petukhova", 
        "givenName": "Galina V.", 
        "id": "sg:person.01147127523.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147127523.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Office of the Director", 
          "id": "https://www.grid.ac/institutes/grid.453125.4", 
          "name": [
            "Division of Veterinary Resources, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eckhaus", 
        "givenName": "Michael", 
        "id": "sg:person.01162405250.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162405250.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frederick National Laboratory for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feigenbaum", 
        "givenName": "Lionel", 
        "id": "sg:person.01307445326.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307445326.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Molecular Cytology Core Facility and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manova", 
        "givenName": "Katia", 
        "id": "sg:person.01000446602.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000446602.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kruhlak", 
        "givenName": "Michael", 
        "id": "sg:person.01340046351.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340046351.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Diabetes and Digestive and Kidney Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419635.c", 
          "name": [
            "Genetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Camerini-Otero", 
        "givenName": "R. Daniel", 
        "id": "sg:person.01204366574.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204366574.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Mouse Cancer Genetics Program, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharan", 
        "givenName": "Shyam", 
        "id": "sg:person.0777537437.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777537437.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rockefeller University", 
          "id": "https://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA", 
            "Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nussenzweig", 
        "givenName": "Michel", 
        "id": "sg:person.0747627025.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747627025.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nussenzweig", 
        "givenName": "Andr\u00e9", 
        "id": "sg:person.01077001037.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077001037.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.15.2985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004316376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000578200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004942118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005184288", 
          "https://doi.org/10.1038/nrm805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005184288", 
          "https://doi.org/10.1038/nrm805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326381", 
          "https://doi.org/10.1038/86920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326381", 
          "https://doi.org/10.1038/86920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0406289102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005510766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20020851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005591897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0020110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005716613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1108297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005911474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007927189", 
          "https://doi.org/10.1038/35007091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007927189", 
          "https://doi.org/10.1038/35007091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009865029", 
          "https://doi.org/10.1038/ncb1004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009865029", 
          "https://doi.org/10.1038/ncb1004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211689200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010387723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011528133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014216009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015088298", 
          "https://doi.org/10.1038/nature03442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015088298", 
          "https://doi.org/10.1038/nature03442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0409191102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016325036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017161096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017842890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkf612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018939673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.2002.01971.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019296982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024136462", 
          "https://doi.org/10.1038/sj.onc.1207447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024136462", 
          "https://doi.org/10.1038/sj.onc.1207447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.13.7376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027929338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.15.5214-5222.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029570337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030622956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m404294200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033406149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200205)32:5<1300::aid-immu1300>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034747463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1998.5657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035905245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/21.6.1447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040360167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042419920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00763-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042779681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00567-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043198083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.17.6006-6016.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043214729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043862402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045888208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00019-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046368167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047129480", 
          "https://doi.org/10.1038/ng845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047129480", 
          "https://doi.org/10.1038/ng845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00566-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047569593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1200304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049982786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gng080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050103266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051326571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1091496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5498.1962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062572391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.12.1286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072297792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074849826", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075315686", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076595641", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076617309", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-07", 
    "datePublishedReg": "2005-07-01", 
    "description": "Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (Atm) in response to ionizing radiation, whereas ataxia-telangiectasia- and Rad3-related (Atr)-dependent signalling and Atm activation in response to ultraviolet light, inhibitors of DNA replication, or hypotonic stress are intact. Expression of the main human NBS allele rescues the lethality of Nbs1-/- mice, but leads to immunodeficiency, cancer predisposition, a defect in meiotic progression in females and cell-cycle checkpoint defects that are associated with a partial reduction in Atm activity. The Mre11 interaction domain of Nbs1 is essential for viability, whereas the Forkhead-associated (FHA) domain is required for T-cell and oocyte development and efficient DNA damage signalling. Reconstitution of Nbs1 knockout mice with various mutant isoforms demonstrates the biological impact of impaired Nbs1 function at the cellular and organismal level.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncb1270", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2726471", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2716532", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723635", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2710204", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2710330", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models", 
    "pagination": "675-685", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7a6f6b232e03f547e6761506efd055e0150570aff923d93060cd5e0395732c70"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15965469"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncb1270"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025699748"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncb1270", 
      "https://app.dimensions.ai/details/publication/pub.1025699748"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118344_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ncb1270"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncb1270'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncb1270'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncb1270'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncb1270'


 

This table displays all metadata directly associated to this object as RDF triples.

483 TRIPLES      21 PREDICATES      110 URIs      55 LITERALS      43 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncb1270 schema:about N0abf9978f50c4d18b5a02712d67855f8
2 N0f716e38b9d04c41bdc1476fdd21bde2
3 N27fbb76e9cc941a58af07629490c2fdc
4 N4b8bedbbe9b943b1b09b725b1dcc3c84
5 N4fba0962fbe349db8b7cef59f96a5b23
6 N518a508def9d4b43ac06c3e0bf6e5e92
7 N56024a553b394126b05185445e62d607
8 N64e6fe377f8f4ac29dda3e72696b8aa7
9 N6b3945a619a842c4adfa5d31ac777f85
10 N7265cc4d0b74417f9419c2a74b2a8da0
11 N77c120c5baea43739d4dbd423829ec3c
12 N782e6ed021754897810ddda19a4a9639
13 N81f6d55b1979489093c2d5605bebeaed
14 N82e2904b53ac4aeeb6141999484e0eab
15 N84390b666ede46ec9e5f7dc07ae53bea
16 N8cb95849ab4b4da1a9a822d25bb0126e
17 N9c782bcab96a4891862afe45a090d860
18 N9f8ebecbd4504dfba9e0bf8b0da13f79
19 Na070549a0597482588044c6279882d80
20 Na88a77f08d2c4ade8bb2cbc12819f7d9
21 Nad4895120a0e4f45a57779965e671be2
22 Nb733ebe18dca464689d73c645cf8b182
23 Nbb3e6292726640a48e1f11a2e4187512
24 Nbdad9d42ead14f3d984bb03c970f6109
25 Nbe7d62569ea5460692fca2dc144144e6
26 Nc280fce1fa8e4ef7b2bea744c227370b
27 Nc32256089e2e43fb8059f29a39ce4ebe
28 Ncde3d6400adf4761a30b344e1eb2996f
29 Nd57e47356b9b4bfcadea52901b2b762b
30 Nd96e3095410e4179bc09b13b9abcf3c5
31 Ne94ca48366e54ab3bbec3844db2636c3
32 Nea692c2ed6ec434f828f39bd57d33fc8
33 Nf86a198d5ce642429563443c4452d047
34 Nffc9524ae0a04e849019347aa8b62fb0
35 anzsrc-for:06
36 anzsrc-for:0601
37 schema:author N6df0d25b17404c7d8ce395e797d7ed1a
38 schema:citation sg:pub.10.1038/35007091
39 sg:pub.10.1038/86920
40 sg:pub.10.1038/nature01368
41 sg:pub.10.1038/nature03442
42 sg:pub.10.1038/ncb1004
43 sg:pub.10.1038/ng845
44 sg:pub.10.1038/nrm805
45 sg:pub.10.1038/sj.onc.1207447
46 https://app.dimensions.ai/details/publication/pub.1074849826
47 https://app.dimensions.ai/details/publication/pub.1075315686
48 https://app.dimensions.ai/details/publication/pub.1076595641
49 https://app.dimensions.ai/details/publication/pub.1076617309
50 https://doi.org/10.1002/1521-4141(200205)32:5<1300::aid-immu1300>3.0.co;2-l
51 https://doi.org/10.1006/geno.1998.5657
52 https://doi.org/10.1016/j.dnarep.2004.03.014
53 https://doi.org/10.1016/j.dnarep.2004.06.001
54 https://doi.org/10.1016/s0092-8674(03)00566-x
55 https://doi.org/10.1016/s0092-8674(03)00567-1
56 https://doi.org/10.1016/s0960-9822(01)00019-7
57 https://doi.org/10.1016/s0960-9822(02)00763-7
58 https://doi.org/10.1038/sj.emboj.7600504
59 https://doi.org/10.1046/j.1365-2249.2002.01971.x
60 https://doi.org/10.1073/pnas.0406289102
61 https://doi.org/10.1073/pnas.0409191102
62 https://doi.org/10.1073/pnas.96.13.7376
63 https://doi.org/10.1074/jbc.c000578200
64 https://doi.org/10.1074/jbc.m211689200
65 https://doi.org/10.1074/jbc.m404294200
66 https://doi.org/10.1084/jem.20020851
67 https://doi.org/10.1084/jem.20041074
68 https://doi.org/10.1084/jem.20041162
69 https://doi.org/10.1093/emboj/21.6.1447
70 https://doi.org/10.1093/emboj/cdg541
71 https://doi.org/10.1093/emboj/cdg630
72 https://doi.org/10.1093/hmg/ddh278
73 https://doi.org/10.1093/nar/25.15.2985
74 https://doi.org/10.1093/nar/gkf612
75 https://doi.org/10.1093/nar/gng080
76 https://doi.org/10.1101/gad.1200304
77 https://doi.org/10.1126/science.1069398
78 https://doi.org/10.1126/science.1091496
79 https://doi.org/10.1126/science.1108297
80 https://doi.org/10.1126/science.290.5498.1962
81 https://doi.org/10.1128/mcb.21.15.5214-5222.2001
82 https://doi.org/10.1128/mcb.21.17.6006-6016.2001
83 https://doi.org/10.1371/journal.pbio.0020110
84 https://doi.org/10.4161/cc.3.12.1286
85 schema:datePublished 2005-07
86 schema:datePublishedReg 2005-07-01
87 schema:description Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (Atm) in response to ionizing radiation, whereas ataxia-telangiectasia- and Rad3-related (Atr)-dependent signalling and Atm activation in response to ultraviolet light, inhibitors of DNA replication, or hypotonic stress are intact. Expression of the main human NBS allele rescues the lethality of Nbs1-/- mice, but leads to immunodeficiency, cancer predisposition, a defect in meiotic progression in females and cell-cycle checkpoint defects that are associated with a partial reduction in Atm activity. The Mre11 interaction domain of Nbs1 is essential for viability, whereas the Forkhead-associated (FHA) domain is required for T-cell and oocyte development and efficient DNA damage signalling. Reconstitution of Nbs1 knockout mice with various mutant isoforms demonstrates the biological impact of impaired Nbs1 function at the cellular and organismal level.
88 schema:genre research_article
89 schema:inLanguage en
90 schema:isAccessibleForFree true
91 schema:isPartOf N1fdf7901a9024223ae2e170844e61e0f
92 Ne240a6c2f7c44ac4915ed8588c8f2c2d
93 sg:journal.1021344
94 schema:name Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
95 schema:pagination 675-685
96 schema:productId N08ea4ba689144aee96a7ccbfa0748c16
97 N4e9e6492bdaa4f94ad0302a5de892e0e
98 N5134643674c74487a9b5c08babe2e0f4
99 N63d9fda09e504652a3abc72135865450
100 Nba3a8bea11d24df7acc16fbbe6244868
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025699748
102 https://doi.org/10.1038/ncb1270
103 schema:sdDatePublished 2019-04-11T12:07
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N353fe684107a4848b6b5e794948d2f60
106 schema:url http://www.nature.com/articles/ncb1270
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N08ea4ba689144aee96a7ccbfa0748c16 schema:name readcube_id
111 schema:value 7a6f6b232e03f547e6761506efd055e0150570aff923d93060cd5e0395732c70
112 rdf:type schema:PropertyValue
113 N0abf9978f50c4d18b5a02712d67855f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Nuclear Proteins
115 rdf:type schema:DefinedTerm
116 N0f716e38b9d04c41bdc1476fdd21bde2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name DNA Damage
118 rdf:type schema:DefinedTerm
119 N0fa5498d6a2144e2a354d62b897c8ac7 rdf:first sg:person.01107263432.77
120 rdf:rest Ne6b8a28e214d402687eb0778e0843290
121 N13ca2b161ee04541829013af1abef6f8 rdf:first N50978add371d449a8167ee2c89bc684c
122 rdf:rest N83fcc3b059c64a679ff561304b36b10d
123 N1fdf7901a9024223ae2e170844e61e0f schema:volumeNumber 7
124 rdf:type schema:PublicationVolume
125 N27fbb76e9cc941a58af07629490c2fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N2c6c8fa4691a465fa336c769de9da117 rdf:first sg:person.01000446602.47
129 rdf:rest N513d5e5741c44d4ab240a65b51db2b30
130 N353fe684107a4848b6b5e794948d2f60 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N37e593b3e39a45b68be8a3da697b7df1 rdf:first sg:person.01034630345.86
133 rdf:rest N0fa5498d6a2144e2a354d62b897c8ac7
134 N3ae12bf9b3cf4828a932518b87e7d79a rdf:first sg:person.0747627025.50
135 rdf:rest Ne302c1b2c6994092b808e0969251ac42
136 N4b8bedbbe9b943b1b09b725b1dcc3c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Cycle Proteins
138 rdf:type schema:DefinedTerm
139 N4d625725f5044f13b2656153f4bd92e3 rdf:first sg:person.01326444625.60
140 rdf:rest N13ca2b161ee04541829013af1abef6f8
141 N4e9e6492bdaa4f94ad0302a5de892e0e schema:name pubmed_id
142 schema:value 15965469
143 rdf:type schema:PropertyValue
144 N4fba0962fbe349db8b7cef59f96a5b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Phosphorylation
146 rdf:type schema:DefinedTerm
147 N50978add371d449a8167ee2c89bc684c schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
148 schema:familyName Yang
149 schema:givenName Yong-Ping
150 rdf:type schema:Person
151 N5134643674c74487a9b5c08babe2e0f4 schema:name nlm_unique_id
152 schema:value 100890575
153 rdf:type schema:PropertyValue
154 N513d5e5741c44d4ab240a65b51db2b30 rdf:first sg:person.01340046351.81
155 rdf:rest Ncf27d506a7af456aa6513493ab37e5c0
156 N518a508def9d4b43ac06c3e0bf6e5e92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name DNA Repair Enzymes
158 rdf:type schema:DefinedTerm
159 N56024a553b394126b05185445e62d607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Gonads
161 rdf:type schema:DefinedTerm
162 N63d9fda09e504652a3abc72135865450 schema:name dimensions_id
163 schema:value pub.1025699748
164 rdf:type schema:PropertyValue
165 N64e6fe377f8f4ac29dda3e72696b8aa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N67e53d6ef26a4be4b54ae4941b4117fe rdf:first sg:person.01162405250.50
169 rdf:rest N8f16a89a2bc046b8a890428270c18bb0
170 N6b3945a619a842c4adfa5d31ac777f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Ataxia Telangiectasia Mutated Proteins
172 rdf:type schema:DefinedTerm
173 N6df0d25b17404c7d8ce395e797d7ed1a rdf:first sg:person.0773142751.20
174 rdf:rest N37e593b3e39a45b68be8a3da697b7df1
175 N7265cc4d0b74417f9419c2a74b2a8da0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Syndrome
177 rdf:type schema:DefinedTerm
178 N77c120c5baea43739d4dbd423829ec3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Lymphoma, Non-Hodgkin
180 rdf:type schema:DefinedTerm
181 N782e6ed021754897810ddda19a4a9639 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Tumor Suppressor Proteins
183 rdf:type schema:DefinedTerm
184 N81f6d55b1979489093c2d5605bebeaed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name DNA-Binding Proteins
186 rdf:type schema:DefinedTerm
187 N82e2904b53ac4aeeb6141999484e0eab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name ATP-Binding Cassette Transporters
189 rdf:type schema:DefinedTerm
190 N83fcc3b059c64a679ff561304b36b10d rdf:first sg:person.01147127523.37
191 rdf:rest N67e53d6ef26a4be4b54ae4941b4117fe
192 N84390b666ede46ec9e5f7dc07ae53bea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Cell Cycle
194 rdf:type schema:DefinedTerm
195 N86413f3f16ae493cbb342bed235717a0 rdf:first sg:person.0777537437.68
196 rdf:rest N3ae12bf9b3cf4828a932518b87e7d79a
197 N8cb95849ab4b4da1a9a822d25bb0126e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Mice, Knockout
199 rdf:type schema:DefinedTerm
200 N8f16a89a2bc046b8a890428270c18bb0 rdf:first sg:person.01307445326.37
201 rdf:rest N2c6c8fa4691a465fa336c769de9da117
202 N9c782bcab96a4891862afe45a090d860 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name T-Lymphocytes
204 rdf:type schema:DefinedTerm
205 N9f8ebecbd4504dfba9e0bf8b0da13f79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Mice, Transgenic
207 rdf:type schema:DefinedTerm
208 Na070549a0597482588044c6279882d80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name DNA Replication
210 rdf:type schema:DefinedTerm
211 Na88a77f08d2c4ade8bb2cbc12819f7d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Immunoglobulin Class Switching
213 rdf:type schema:DefinedTerm
214 Nad4895120a0e4f45a57779965e671be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Mice
216 rdf:type schema:DefinedTerm
217 Nb733ebe18dca464689d73c645cf8b182 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Chromosome Aberrations
219 rdf:type schema:DefinedTerm
220 Nba3a8bea11d24df7acc16fbbe6244868 schema:name doi
221 schema:value 10.1038/ncb1270
222 rdf:type schema:PropertyValue
223 Nbb3e6292726640a48e1f11a2e4187512 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name MRE11 Homologue Protein
225 rdf:type schema:DefinedTerm
226 Nbdad9d42ead14f3d984bb03c970f6109 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Female
228 rdf:type schema:DefinedTerm
229 Nbe7d62569ea5460692fca2dc144144e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name B-Lymphocytes
231 rdf:type schema:DefinedTerm
232 Nc280fce1fa8e4ef7b2bea744c227370b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Male
234 rdf:type schema:DefinedTerm
235 Nc32256089e2e43fb8059f29a39ce4ebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Binding Sites
237 rdf:type schema:DefinedTerm
238 Nc94fb49c6ff14d2b83515c5e6e521113 rdf:first sg:person.015511120215.41
239 rdf:rest N4d625725f5044f13b2656153f4bd92e3
240 Ncde3d6400adf4761a30b344e1eb2996f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
241 schema:name Disease Models, Animal
242 rdf:type schema:DefinedTerm
243 Ncf27d506a7af456aa6513493ab37e5c0 rdf:first sg:person.01204366574.06
244 rdf:rest N86413f3f16ae493cbb342bed235717a0
245 Nd57e47356b9b4bfcadea52901b2b762b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Tumor Suppressor Protein p53
247 rdf:type schema:DefinedTerm
248 Nd96e3095410e4179bc09b13b9abcf3c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
249 schema:name Protein-Serine-Threonine Kinases
250 rdf:type schema:DefinedTerm
251 Ne240a6c2f7c44ac4915ed8588c8f2c2d schema:issueNumber 7
252 rdf:type schema:PublicationIssue
253 Ne302c1b2c6994092b808e0969251ac42 rdf:first sg:person.01077001037.74
254 rdf:rest rdf:nil
255 Ne6b8a28e214d402687eb0778e0843290 rdf:first sg:person.0605734250.22
256 rdf:rest Nc94fb49c6ff14d2b83515c5e6e521113
257 Ne94ca48366e54ab3bbec3844db2636c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
258 schema:name Chromosome Breakage
259 rdf:type schema:DefinedTerm
260 Nea692c2ed6ec434f828f39bd57d33fc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
261 schema:name Mutation
262 rdf:type schema:DefinedTerm
263 Nf86a198d5ce642429563443c4452d047 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
264 schema:name Chromosome Disorders
265 rdf:type schema:DefinedTerm
266 Nffc9524ae0a04e849019347aa8b62fb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
267 schema:name Genetic Predisposition to Disease
268 rdf:type schema:DefinedTerm
269 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
270 schema:name Biological Sciences
271 rdf:type schema:DefinedTerm
272 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
273 schema:name Biochemistry and Cell Biology
274 rdf:type schema:DefinedTerm
275 sg:grant.2710204 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1270
276 rdf:type schema:MonetaryGrant
277 sg:grant.2710330 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1270
278 rdf:type schema:MonetaryGrant
279 sg:grant.2716532 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1270
280 rdf:type schema:MonetaryGrant
281 sg:grant.2723635 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1270
282 rdf:type schema:MonetaryGrant
283 sg:grant.2726471 http://pending.schema.org/fundedItem sg:pub.10.1038/ncb1270
284 rdf:type schema:MonetaryGrant
285 sg:journal.1021344 schema:issn 1465-7392
286 1476-4679
287 schema:name Nature Cell Biology
288 rdf:type schema:Periodical
289 sg:person.01000446602.47 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
290 schema:familyName Manova
291 schema:givenName Katia
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000446602.47
293 rdf:type schema:Person
294 sg:person.01034630345.86 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
295 schema:familyName Celeste
296 schema:givenName Arkady
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034630345.86
298 rdf:type schema:Person
299 sg:person.01077001037.74 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
300 schema:familyName Nussenzweig
301 schema:givenName André
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077001037.74
303 rdf:type schema:Person
304 sg:person.01107263432.77 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
305 schema:familyName Fernandez-Capetillo
306 schema:givenName Oscar
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263432.77
308 rdf:type schema:Person
309 sg:person.01147127523.37 schema:affiliation https://www.grid.ac/institutes/grid.419635.c
310 schema:familyName Petukhova
311 schema:givenName Galina V.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147127523.37
313 rdf:type schema:Person
314 sg:person.01162405250.50 schema:affiliation https://www.grid.ac/institutes/grid.453125.4
315 schema:familyName Eckhaus
316 schema:givenName Michael
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162405250.50
318 rdf:type schema:Person
319 sg:person.01204366574.06 schema:affiliation https://www.grid.ac/institutes/grid.419635.c
320 schema:familyName Camerini-Otero
321 schema:givenName R. Daniel
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204366574.06
323 rdf:type schema:Person
324 sg:person.01307445326.37 schema:affiliation https://www.grid.ac/institutes/grid.418021.e
325 schema:familyName Feigenbaum
326 schema:givenName Lionel
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307445326.37
328 rdf:type schema:Person
329 sg:person.01326444625.60 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
330 schema:familyName Van Laethem
331 schema:givenName Francois
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326444625.60
333 rdf:type schema:Person
334 sg:person.01340046351.81 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
335 schema:familyName Kruhlak
336 schema:givenName Michael
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340046351.81
338 rdf:type schema:Person
339 sg:person.015511120215.41 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
340 schema:familyName San Martin
341 schema:givenName Bernardo Reina
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015511120215.41
343 rdf:type schema:Person
344 sg:person.0605734250.22 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
345 schema:familyName Chen
346 schema:givenName Hua-Tang
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605734250.22
348 rdf:type schema:Person
349 sg:person.0747627025.50 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
350 schema:familyName Nussenzweig
351 schema:givenName Michel
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747627025.50
353 rdf:type schema:Person
354 sg:person.0773142751.20 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
355 schema:familyName Difilippantonio
356 schema:givenName Simone
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773142751.20
358 rdf:type schema:Person
359 sg:person.0777537437.68 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
360 schema:familyName Sharan
361 schema:givenName Shyam
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777537437.68
363 rdf:type schema:Person
364 sg:pub.10.1038/35007091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007927189
365 https://doi.org/10.1038/35007091
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/86920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005326381
368 https://doi.org/10.1038/86920
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/nature01368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815475
371 https://doi.org/10.1038/nature01368
372 rdf:type schema:CreativeWork
373 sg:pub.10.1038/nature03442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015088298
374 https://doi.org/10.1038/nature03442
375 rdf:type schema:CreativeWork
376 sg:pub.10.1038/ncb1004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009865029
377 https://doi.org/10.1038/ncb1004
378 rdf:type schema:CreativeWork
379 sg:pub.10.1038/ng845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047129480
380 https://doi.org/10.1038/ng845
381 rdf:type schema:CreativeWork
382 sg:pub.10.1038/nrm805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005184288
383 https://doi.org/10.1038/nrm805
384 rdf:type schema:CreativeWork
385 sg:pub.10.1038/sj.onc.1207447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024136462
386 https://doi.org/10.1038/sj.onc.1207447
387 rdf:type schema:CreativeWork
388 https://app.dimensions.ai/details/publication/pub.1074849826 schema:CreativeWork
389 https://app.dimensions.ai/details/publication/pub.1075315686 schema:CreativeWork
390 https://app.dimensions.ai/details/publication/pub.1076595641 schema:CreativeWork
391 https://app.dimensions.ai/details/publication/pub.1076617309 schema:CreativeWork
392 https://doi.org/10.1002/1521-4141(200205)32:5<1300::aid-immu1300>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1034747463
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1006/geno.1998.5657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035905245
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1016/j.dnarep.2004.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030622956
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1016/j.dnarep.2004.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051326571
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1016/s0092-8674(03)00566-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047569593
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1016/s0092-8674(03)00567-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043198083
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1016/s0960-9822(01)00019-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046368167
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1016/s0960-9822(02)00763-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042779681
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1038/sj.emboj.7600504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045888208
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1046/j.1365-2249.2002.01971.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019296982
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1073/pnas.0406289102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005510766
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1073/pnas.0409191102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016325036
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1073/pnas.96.13.7376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027929338
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1074/jbc.c000578200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004942118
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1074/jbc.m211689200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010387723
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1074/jbc.m404294200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033406149
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1084/jem.20020851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005591897
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1084/jem.20041074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042419920
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1084/jem.20041162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043862402
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1093/emboj/21.6.1447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040360167
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1093/emboj/cdg541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011528133
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1093/emboj/cdg630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014216009
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1093/hmg/ddh278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017842890
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1093/nar/25.15.2985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004316376
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1093/nar/gkf612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018939673
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1093/nar/gng080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050103266
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1101/gad.1200304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049982786
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1126/science.1069398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017161096
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1126/science.1091496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449100
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1126/science.1108297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005911474
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1126/science.290.5498.1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572391
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1128/mcb.21.15.5214-5222.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029570337
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1128/mcb.21.17.6006-6016.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043214729
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1371/journal.pbio.0020110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005716613
459 rdf:type schema:CreativeWork
460 https://doi.org/10.4161/cc.3.12.1286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297792
461 rdf:type schema:CreativeWork
462 https://www.grid.ac/institutes/grid.134907.8 schema:alternateName Rockefeller University
463 schema:name Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
464 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
465 rdf:type schema:Organization
466 https://www.grid.ac/institutes/grid.418021.e schema:alternateName Frederick National Laboratory for Cancer Research
467 schema:name SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
468 rdf:type schema:Organization
469 https://www.grid.ac/institutes/grid.419635.c schema:alternateName National Institute of Diabetes and Digestive and Kidney Diseases
470 schema:name Genetics and Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
471 rdf:type schema:Organization
472 https://www.grid.ac/institutes/grid.453125.4 schema:alternateName Office of the Director
473 schema:name Division of Veterinary Resources, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD 20892, USA.
474 rdf:type schema:Organization
475 https://www.grid.ac/institutes/grid.48336.3a schema:alternateName National Cancer Institute
476 schema:name Mouse Cancer Genetics Program, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.
477 rdf:type schema:Organization
478 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
479 schema:name Molecular Cytology Core Facility and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
480 rdf:type schema:Organization
481 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
482 schema:name Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
483 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...