Histone H3 lysine 4 methylation patterns in higher eukaryotic genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01

AUTHORS

Robert Schneider, Andrew J Bannister, Fiona A Myers, Alan W Thorne, Colyn Crane-Robinson, Tony Kouzarides

ABSTRACT

Lysine residues within histones can be mono-, di - or tri-methylated. In Saccharomyces cerevisiae tri-methylation of Lys 4 of histone H3 (K4/H3) correlates with transcriptional activity, but little is known about this methylation state in higher eukaryotes. Here, we examine the K4/H3 methylation pattern at the promoter and transcribed region of metazoan genes. We analysed chicken genes that are developmentally regulated, constitutively active or inactive. We found that the pattern of K4/H3 methylation shows similarities to S. cerevisiae. Tri-methyl K4/H3 peaks in the 5' transcribed region and active genes can be discriminated by high levels of tri-methyl K4/H3 compared with inactive genes. However, our results also identify clear differences compared to yeast, as significant levels of K4/H3 methylation are present on inactive genes within the beta-globin locus, implicating this modification in maintaining a 'poised' chromatin state. In addition, K4/H3 di-methylation is not genome-wide and di-methylation is not uniformly distributed throughout the transcribed region. These results indicate that in metazoa, di- and tri-methylation of K4/H3 is linked to active transcription and that significant differences exist in the genome-wide methylation pattern as compared with S. cerevisiae. More... »

PAGES

73-77

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1076

DOI

http://dx.doi.org/10.1038/ncb1076

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014358072

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14661024


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