Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

Manabu Furukawa, Yizhou Joseph He, Christoph Borchers, Yue Xiong

ABSTRACT

The concentrations and functions of many cellular proteins are regulated by the ubiquitin pathway. Cullin family proteins bind with the RING-finger protein Roc1 to recruit the ubiquitin-conjugating enzyme (E2) to the ubiquitin ligase complex (E3). Cul1 and Cul7, but not other cullins, bind to an adaptor protein, Skp1. Cul1 associates with one of many F-box proteins through Skp1 to assemble various SCF-Roc1 E3 ligases that each selectively ubiquitinate one or more specific substrates. Here, we show that Cul3, but not other cullins, binds directly to multiple BTB domains through a conserved amino-terminal domain. In vitro, Cul3 promoted ubiquitination of Caenorhabditis elegans MEI-1, a katanin-like protein whose degradation requires the function of both Cul3 and BTB protein MEL-26. We suggest that in vivo there exists a potentially large number of BCR3 (BTB-Cul3-Roc1) E3 ubiquitin ligases. More... »

PAGES

1001-1007

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncb1056

DOI

http://dx.doi.org/10.1038/ncb1056

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047237091

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14528312


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