Isolation of multipotent adult stem cells from the dermis of mammalian skin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-08-13

AUTHORS

Jean G. Toma, Mahnaz Akhavan, Karl J. L. Fernandes, Fanie Barnabé-Heider, Abbas Sadikot, David R. Kaplan, Freda D. Miller

ABSTRACT

We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipocytes. Similar precursors that produce neuron-specific proteins upon differentiation can be isolated from adult human scalp. Because these cells (termed SKPs for skin-derived precursors) generate both neural and mesodermal progeny, we propose that they represent a novel multipotent adult stem cell and suggest that skin may provide an accessible, autologous source of stem cells for transplantation. More... »

PAGES

778-784

Journal

TITLE

Nature Cell Biology

ISSUE

9

VOLUME

3

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncb0901-778

    DOI

    http://dx.doi.org/10.1038/ncb0901-778

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018972963

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11533656


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