In vivo cancer targeting and imaging with semiconductor quantum dots View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-08

AUTHORS

Xiaohu Gao, Yuanyuan Cui, Richard M Levenson, Leland W K Chung, Shuming Nie

ABSTRACT

We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor-targeting ligands and drug-delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer-specific cell surface biomarkers. Using both subcutaneous injection of QD-tagged cancer cells and systemic injection of multifunctional QD probes, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. We have also integrated a whole-body macro-illumination system with wavelength-resolved spectral imaging for efficient background removal and precise delineation of weak spectral signatures. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo. More... »

PAGES

969-976

Journal

TITLE

Nature Biotechnology

ISSUE

8

VOLUME

22

Author Affiliations

Related Patents

  • Mycobacterial Protein Detection
  • Nanoparticle-Amphipol Complexes For Nucleic Acid Intracellular Delivery And Imaging
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Methods And Compositions For Targeted Release Of Molecules From Nanoscale Carriers
  • Nanoparticle Compositions
  • Surface Enhanced Spectroscopy-Active Composite Nanoparticles Comprising Raman-Active Reporter Molecules
  • Polymeric Nanoparticles For Ultrasound Imaging And Therapy
  • Long Circulating Nanoparticles For Sustained Release Of Therapeutic Agents
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Multifunctional Nanostructures, Methods Of Synthesizing Thereof, And Methods Of Use Thereof
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Therapeutic Polymeric Nanoparticles With Mtor Inhibitors And Methods Of Making And Using Same
  • Flow Focusing Method And System For Forming Concentrated Volumes Of Microbeads, And Microbeads Formed Further Thereto
  • Semiconductor Nanocrystal Probes For Biological Applications And Process For Making And Using Such Probes
  • Methods And Compositions For Imaging Cancer Cells
  • Ph-Sensitive Imaging Agents
  • Therapeutic Particles Suitable For Parenteral Administration And Methods Of Making And Using Same
  • Nanoparticle Complexes Of Anti-Cd20 Antibodies, Albumin And Paclitaxel
  • Therapeutic Polymeric Nanoparticle Compositions With High Glass Transition Temperature Or High Molecular Weight Copolymers
  • Method Of Tagging Materials With Surface-Enhanced Spectroscopy-Active Sandwich Particles
  • Method For Detection Of Antigens
  • Mutant Rb69 Dna Polymerase
  • Therapeutic Polymeric Nanoparticles With Mtor Inhibitors And Methods Of Making And Using Same
  • High Affinity Anti-Prostate Stem Cell Antigen (Psca) Antibodies For Cancer Targeting And Detection
  • Nanotubes As Mitochondrial Uncouplers
  • Therapeutic Polymeric Nanoparticles Comprising Vinca Alkaloids And Methods Of Making And Using Same
  • Mycobacterial Detection
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Methods And Compositions For Targeted Release Of Molecules From Nanoscale Carriers
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Process For Obtaining Silica Nanoparticles Incorporating Hydrophilic Or Water Miscible Products And Process For Their Immobilization And Encapsulation When Applied To Textile Fibres
  • Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods Of Making And Using The Same
  • Single-Use Handheld Diagnostic Test Device, And An Associated System And Method For Testing Biological And Environmental Test Samples
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Dose Selection Of Adjuvanted Synthetic Nanocarriers
  • Nanotubes As Mitochondrial Uncouplers
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Materials And Methods For Near-Infrared And Infrared Lymph Node Mapping
  • Nanoparticle Compositions
  • Bioconjugated Nanostructures, Methods Of Fabrication Thereof, And Methods Of Use Thereof
  • Early Cancer Detection And Enhanced Immunotherapy
  • Nanoparticulate Chemical Sensors Using Sers
  • Therapeutic Polymeric Nanoparticles Comprising Vinca Alkaloids And Methods Of Making And Using Same
  • Polymer Nanoparticles Coated By Magnetic Metal Oxide And Uses Thereof
  • In Vivo Drug Concentration Distribution Measuring Device, Variable-Wavelength Filter Used For The Same, And In Vivo Drug Concentration Distribution Measuring Method
  • Nanoparticles And Their Use For Multifunctional Bioimaging
  • Quantum Dots, Methods Of Making Quantum Dots, And Methods Of Using Quantum Dots
  • Systems And Methods For In-Vivo Optical Imaging And Measurement
  • Nanotubes As Mitochondrial Uncouplers
  • Bioconjugated Nanostructures, Methods Of Fabrication Thereof, And Methods Of Use Thereof
  • Supramolecular Approach For Preparation Of Size Controllable Nanoparticles
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Systems And Methods For Enhancing Fluorescent Detection Of Target Molecules In A Test Sample
  • Quantum Dots, Methods Of Making Quantum Dots, And Methods Of Using Quantum Dots
  • Nanocomposites, Methods Of Making Same, And Applications Of Same For Multicolor Surface Enhanced Raman Spectroscopy (Sers) Detections
  • Nanoparticles For Treatment Of Allergy
  • High Affinity Anti-Prostate Stem Cell Antigen (Psca) Antibodies For Cancer Targeting And Detection
  • Semiconductor Nanocrystal Probes For Biological Applications And Process For Making And Using Such Probes
  • In Vivo Tumor Targeting And Spectroscopic Detection With Surface-Enhanced Raman Nanoparticle Tags
  • Therapeutic Polymeric Nanoparticle Compositions With High Glass Transition Temperature Or High Molecular Weight Copolymers
  • Long Circulating Nanoparticles For Sustained Release Of Therapeutic Agents
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Bio-Threat Alert System
  • Nanostructures, Methods Of Synthesizing Thereof, And Methods Of Use Thereof
  • Nir Fluorescence Of Heavy Water
  • Therapeutic Polymeric Nanoparticle Compositions With High Glass Transition Temperature Or High Molecular Weight Copolymers
  • Fluorescent Nanoparticles
  • Therapeutic Particles Suitable For Parenteral Administration And Methods Of Making And Using Same
  • Detection Of Mycobacterial Protein Targets Using Quantum Dots (Qds) And Immunomagnetic Seperation
  • Methods Of Use For Surface Enhanced Spectroscopy-Active Composite Nanoparticles
  • Handheld Diagnostic Test Device And Method For Use With An Electronic Device And A Test Cartridge In A Rapid Diagnostic Test
  • Coated Quantum Dots And Methods Of Making And Using Thereof
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Systems And Methods For In-Vivo And Optical Imaging And Measurement
  • Mutant Rb69 Dna Polymerase
  • Cancer Treatments
  • Methods To Regulate Polarization And Enhance Function Of Cells
  • Process For Preparing Therapeutic Nanoparticles
  • Therapeutic Polymeric Nanoparticle Compositions With High Glass Transition Temperature Or High Molecular Weight Copolymers
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Optimized Adhesin Fragments And Corresponding Nanoparticles
  • Immune System Modulators And Compositions
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Particulate Drug Delivery Methods
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods Of Making And Using The Same
  • Immunomodulatory Agent-Polymeric Compounds
  • Nanocomposites And Methods Of Making Same
  • Microfluidic System And Method To Test For Target Molecules In A Biological Sample
  • Photosensitizing Antibody-Fluorophore Conjugates
  • Systems And Methods For In-Vivo Optical Imaging And Measurement
  • Method For Tagging Material With Surface-Enhanced Spectroscopy (Ses)-Active Composite Nanoparticles
  • Immunomodulatory Agent-Polymeric Compounds
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Flow Focusing Method And System For Forming Concentrated Volumes Of Microbeads, And Microbeads Formed Further Thereto
  • Stable Formulations For Lyophilizing Therapeutic Particles
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Single-Use Handheld Diagnostic Test Device, And An Associated System And Method For Testing Biological And Environmental Test Samples
  • Methods For Producing Nanoparticles And Using Same
  • Quantum Dots For Diagnostic Imaging
  • Quantum Dot—Polymer Nanocomposite Sensor Array For Chemical Vapor Sensing
  • Methods And Reagents For Preparing Multifunctional Probes
  • Methods And Reagents For Preparing Multifunctional Probes
  • Quantum Dot-Polymer Nanocomposite For Optical Sensing
  • Dose Selection Of Adjuvanted Synthetic Nanocarriers
  • Engineered Anti-Prostate Stem Cell Antigen (Psca) Antibodies For Cancer Targeting
  • Mutant Rb69 Dna Polymerase
  • In Vivo Tumor Targeting And Spectroscopic Detection With Surface-Enhanced Raman Nanoparticle Tags
  • Peptide Ligands For Clusterin And Uses Thereof
  • Nanotubes As Mitochondrial Uncouplers
  • System And Method Of Deconvolving Multiplexed Fluorescence Spectral Signals Generated By Quantum Dot Optical Coding Technology
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Nanotubes As Mitochondrial Uncouplers
  • Systems And Methods For Manufacturing Quantum Dot-Doped Polymer Microbeads
  • Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
  • Methods For Reducing Global Chronic Inflammation And The Presence Of Melanoma
  • Cancer Cell Targeting Using Nanoparticles
  • Integrated System And Methods For Real-Time Anatomical Guidance In A Diagnostic Or Therapeutic Procedure
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt994

    DOI

    http://dx.doi.org/10.1038/nbt994

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039601245

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15258594


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coated Materials, Biocompatible", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Delivery Systems", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Image Enhancement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Materials Testing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microscopy, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prostatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quantum Dots", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Semiconductors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spectrometry, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Distribution", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Emory University", 
              "id": "https://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Biomedical Engineering, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Xiaohu", 
            "id": "sg:person.01256137310.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256137310.20"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Cui", 
            "givenName": "Yuanyuan", 
            "type": "Person"
          }, 
          {
            "familyName": "Levenson", 
            "givenName": "Richard M", 
            "id": "sg:person.01362455574.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362455574.53"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Chung", 
            "givenName": "Leland W K", 
            "id": "sg:person.01341170162.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341170162.48"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Nie", 
            "givenName": "Shuming", 
            "id": "sg:person.01142502201.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142502201.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nbt920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002851728", 
              "https://doi.org/10.1038/nbt920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002851728", 
              "https://doi.org/10.1038/nbt920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0090-4295(00)01094-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005640176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja021096v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005973055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja021096v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005973055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0958-1669(02)00282-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006230504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-7799(03)00209-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006405196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-7799(03)00209-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006405196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5385.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006510768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00306-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006642632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja003633m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007562638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja003633m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007562638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383802a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009052486", 
              "https://doi.org/10.1038/383802a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010845241", 
              "https://doi.org/10.1038/nrd1088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010845241", 
              "https://doi.org/10.1038/nrd1088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/krnfwqqeuplql76l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011755620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/90228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012707267", 
              "https://doi.org/10.1038/90228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/90228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012707267", 
              "https://doi.org/10.1038/90228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0927-7765(99)00058-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014641728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80149-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015646836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1077194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015841885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl0155532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016049622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl0155532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016049622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017554135", 
              "https://doi.org/10.1038/74464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017554135", 
              "https://doi.org/10.1038/74464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5385.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018609686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5346.2114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018769951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0103-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019369675", 
              "https://doi.org/10.1038/nbt0103-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0103-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019369675", 
              "https://doi.org/10.1038/nbt0103-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc034153y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020647724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc034153y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020647724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1735443100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022139285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1088525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023635206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023895188", 
              "https://doi.org/10.1038/nbt764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023895188", 
              "https://doi.org/10.1038/nbt764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028221069", 
              "https://doi.org/10.1038/nbt929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028221069", 
              "https://doi.org/10.1038/nbt929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032148867", 
              "https://doi.org/10.1038/nmat997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032148867", 
              "https://doi.org/10.1038/nmat997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl0347334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034740936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl0347334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034740936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036431452", 
              "https://doi.org/10.1038/nature01663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036431452", 
              "https://doi.org/10.1038/nature01663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036730414", 
              "https://doi.org/10.1038/nmat961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036730414", 
              "https://doi.org/10.1038/nmat961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1083780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036778978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036950132", 
              "https://doi.org/10.1038/nbt767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036950132", 
              "https://doi.org/10.1038/nbt767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.152463399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039713086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bioeng.1.1.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044095591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-3773(20011119)40:22<4128::aid-anie4128>3.0.co;2-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044539382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0361749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045211888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0361749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045211888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000091655.77601.0c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045587889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000091655.77601.0c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045587889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja035000o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046129609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja035000o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046129609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540305100801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046364223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540305100801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046364223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.052029099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048311899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-3773(19981102)37:20<2754::aid-anie2754>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048587498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1995.2373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050172714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0354600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0354600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015555d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015555d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015563u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015563u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi962148u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055212798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi962148u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055212798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja002535y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055717795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja002535y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055717795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja003486s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055725399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja003486s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055725399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja025946i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055830704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja025946i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055830704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp0308110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056052541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp0308110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056052541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.86.3132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060822831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.86.3132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060822831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/3.64354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061149098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1078192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062447105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5251.933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1162/153535003765276282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063350382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1162/15353500200302163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063350382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1162/15353500200302163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063350382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075198228", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00330-002-1524-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075222288", 
              "https://doi.org/10.1007/s00330-002-1524-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-08", 
        "datePublishedReg": "2004-08-01", 
        "description": "We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor-targeting ligands and drug-delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer-specific cell surface biomarkers. Using both subcutaneous injection of QD-tagged cancer cells and systemic injection of multifunctional QD probes, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. We have also integrated a whole-body macro-illumination system with wavelength-resolved spectral imaging for efficient background removal and precise delineation of weak spectral signatures. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nbt994", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2435791", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7142868", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2437858", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2516430", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115214", 
            "issn": [
              "1087-0156", 
              "1546-1696"
            ], 
            "name": "Nature Biotechnology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "In vivo cancer targeting and imaging with semiconductor quantum dots", 
        "pagination": "969-976", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "bca426598dd8271efb4f0d5ba45b815dc55c9631e0b50eebe465783d4498e737"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15258594"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9604648"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nbt994"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039601245"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nbt994", 
          "https://app.dimensions.ai/details/publication/pub.1039601245"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54017_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nbt/journal/v22/n8/full/nbt994.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt994'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt994'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt994'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt994'


     

    This table displays all metadata directly associated to this object as RDF triples.

    359 TRIPLES      21 PREDICATES      105 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nbt994 schema:about N26b7972406024126b03b210ae75d6320
    2 N2b6bc02ea4814df48d59941919a09040
    3 N3236888540814b66b47c456360a834b7
    4 N39de0e56dbb44a789fc7893e7c798841
    5 N57ed452248c345048c6b09cf3758102b
    6 N5b6fc9f9f88346fe82f3842c4e4dbc65
    7 N73788646b55d42afada94b4511688ddd
    8 N74a823e8d2cb41a9b2e4510dddd62e2a
    9 N9bbbe11c65fa463595c067c62c9a4732
    10 N9d5f617c37fd45729cdb281ae3f12567
    11 Nab5962e52aee406993ca1860063d057f
    12 Nab9f8cde680c4feba304b37e513e28ef
    13 Nb2f624f906f34f1194e5a528c7b4776a
    14 Nb4c50ccc6dc54536890b7f48a57713a4
    15 Ne71dac92c2d94b35bcc1b3252fa88928
    16 Ne83693c44fb34ee1b206fb2be32eaa8b
    17 Ne8e3a9c0a40044cdb8a71339c427ba31
    18 Nf49aa0e57d0d4407ab963502bfe22ad5
    19 Nfb59e9484caf47018aad969fdff06095
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author N69882085f93b44c49eeffd2e52fd48a6
    23 schema:citation sg:pub.10.1007/s00330-002-1524-x
    24 sg:pub.10.1038/383802a0
    25 sg:pub.10.1038/74464
    26 sg:pub.10.1038/90228
    27 sg:pub.10.1038/nature01663
    28 sg:pub.10.1038/nbt0103-32
    29 sg:pub.10.1038/nbt764
    30 sg:pub.10.1038/nbt767
    31 sg:pub.10.1038/nbt920
    32 sg:pub.10.1038/nbt929
    33 sg:pub.10.1038/nmat961
    34 sg:pub.10.1038/nmat997
    35 sg:pub.10.1038/nrd1088
    36 https://app.dimensions.ai/details/publication/pub.1075198228
    37 https://doi.org/10.1002/(sici)1521-3773(19981102)37:20<2754::aid-anie2754>3.0.co;2-3
    38 https://doi.org/10.1002/1521-3773(20011119)40:22<4128::aid-anie4128>3.0.co;2-s
    39 https://doi.org/10.1006/bbrc.1995.2373
    40 https://doi.org/10.1016/s0090-4295(00)01094-3
    41 https://doi.org/10.1016/s0167-7799(03)00209-9
    42 https://doi.org/10.1016/s0168-3659(01)00306-6
    43 https://doi.org/10.1016/s0927-7765(99)00058-2
    44 https://doi.org/10.1016/s0958-1669(02)00282-3
    45 https://doi.org/10.1016/s1074-7613(00)80149-1
    46 https://doi.org/10.1021/ac0354600
    47 https://doi.org/10.1021/bc015555d
    48 https://doi.org/10.1021/bc015563u
    49 https://doi.org/10.1021/bc034153y
    50 https://doi.org/10.1021/bi962148u
    51 https://doi.org/10.1021/ja002535y
    52 https://doi.org/10.1021/ja003486s
    53 https://doi.org/10.1021/ja003633m
    54 https://doi.org/10.1021/ja021096v
    55 https://doi.org/10.1021/ja025946i
    56 https://doi.org/10.1021/ja035000o
    57 https://doi.org/10.1021/ja0361749
    58 https://doi.org/10.1021/jp0308110
    59 https://doi.org/10.1021/nl0155532
    60 https://doi.org/10.1021/nl0347334
    61 https://doi.org/10.1073/pnas.052029099
    62 https://doi.org/10.1073/pnas.152463399
    63 https://doi.org/10.1073/pnas.1735443100
    64 https://doi.org/10.1097/01.ju.0000091655.77601.0c
    65 https://doi.org/10.1103/physrevlett.86.3132
    66 https://doi.org/10.1109/3.64354
    67 https://doi.org/10.1126/science.1077194
    68 https://doi.org/10.1126/science.1078192
    69 https://doi.org/10.1126/science.1083780
    70 https://doi.org/10.1126/science.1088525
    71 https://doi.org/10.1126/science.271.5251.933
    72 https://doi.org/10.1126/science.278.5346.2114
    73 https://doi.org/10.1126/science.281.5385.2013
    74 https://doi.org/10.1126/science.281.5385.2016
    75 https://doi.org/10.1146/annurev.bioeng.1.1.241
    76 https://doi.org/10.1162/15353500200302163
    77 https://doi.org/10.1162/153535003765276282
    78 https://doi.org/10.1177/002215540305100801
    79 https://doi.org/10.1309/krnfwqqeuplql76l
    80 schema:datePublished 2004-08
    81 schema:datePublishedReg 2004-08-01
    82 schema:description We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor-targeting ligands and drug-delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer-specific cell surface biomarkers. Using both subcutaneous injection of QD-tagged cancer cells and systemic injection of multifunctional QD probes, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. We have also integrated a whole-body macro-illumination system with wavelength-resolved spectral imaging for efficient background removal and precise delineation of weak spectral signatures. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.
    83 schema:genre research_article
    84 schema:inLanguage en
    85 schema:isAccessibleForFree false
    86 schema:isPartOf N920acd0731f4422490bda1fd2230c4be
    87 Nefb346ce38a7435f84f8d8c8d84f534c
    88 sg:journal.1115214
    89 schema:name In vivo cancer targeting and imaging with semiconductor quantum dots
    90 schema:pagination 969-976
    91 schema:productId N333ee2daa5e34fb483c033a9ed637a18
    92 N6a6a4489c1ba474f8f63416577451335
    93 N87efda1225dc48bb98931d47b878a089
    94 Nc10740a18c54406094d55cac66fd1de7
    95 Nfeda217bbb98433fbae9e22f57a78e9b
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039601245
    97 https://doi.org/10.1038/nbt994
    98 schema:sdDatePublished 2019-04-11T12:16
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher N3cdcd3054aa64e5eb4c998d0800e6d80
    101 schema:url http://www.nature.com/nbt/journal/v22/n8/full/nbt994.html
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N26b7972406024126b03b210ae75d6320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Animals
    107 rdf:type schema:DefinedTerm
    108 N2b6bc02ea4814df48d59941919a09040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Semiconductors
    110 rdf:type schema:DefinedTerm
    111 N3236888540814b66b47c456360a834b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Mice
    113 rdf:type schema:DefinedTerm
    114 N333ee2daa5e34fb483c033a9ed637a18 schema:name dimensions_id
    115 schema:value pub.1039601245
    116 rdf:type schema:PropertyValue
    117 N39de0e56dbb44a789fc7893e7c798841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Quantum Dots
    119 rdf:type schema:DefinedTerm
    120 N3cdcd3054aa64e5eb4c998d0800e6d80 schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N57ed452248c345048c6b09cf3758102b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Humans
    124 rdf:type schema:DefinedTerm
    125 N5b6fc9f9f88346fe82f3842c4e4dbc65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Spectrometry, Fluorescence
    127 rdf:type schema:DefinedTerm
    128 N69882085f93b44c49eeffd2e52fd48a6 rdf:first sg:person.01256137310.20
    129 rdf:rest N77a0070221c3441e8b4c4675562f592a
    130 N6a6a4489c1ba474f8f63416577451335 schema:name doi
    131 schema:value 10.1038/nbt994
    132 rdf:type schema:PropertyValue
    133 N73788646b55d42afada94b4511688ddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Mice, Nude
    135 rdf:type schema:DefinedTerm
    136 N74a823e8d2cb41a9b2e4510dddd62e2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Image Enhancement
    138 rdf:type schema:DefinedTerm
    139 N77a0070221c3441e8b4c4675562f592a rdf:first Nb283470439004b41bd8dceacec3bd491
    140 rdf:rest Nb66a5d31944046ecbce63296d535174a
    141 N87efda1225dc48bb98931d47b878a089 schema:name nlm_unique_id
    142 schema:value 9604648
    143 rdf:type schema:PropertyValue
    144 N920acd0731f4422490bda1fd2230c4be schema:volumeNumber 22
    145 rdf:type schema:PublicationVolume
    146 N9bbbe11c65fa463595c067c62c9a4732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Drug Delivery Systems
    148 rdf:type schema:DefinedTerm
    149 N9cf4c1364f3b40f496b7e9b4723c04d4 rdf:first sg:person.01142502201.76
    150 rdf:rest rdf:nil
    151 N9d5f617c37fd45729cdb281ae3f12567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Coated Materials, Biocompatible
    153 rdf:type schema:DefinedTerm
    154 Nab5962e52aee406993ca1860063d057f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Male
    156 rdf:type schema:DefinedTerm
    157 Nab9f8cde680c4feba304b37e513e28ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Cell Line, Tumor
    159 rdf:type schema:DefinedTerm
    160 Nb283470439004b41bd8dceacec3bd491 schema:familyName Cui
    161 schema:givenName Yuanyuan
    162 rdf:type schema:Person
    163 Nb2f624f906f34f1194e5a528c7b4776a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Breast Neoplasms
    165 rdf:type schema:DefinedTerm
    166 Nb4c50ccc6dc54536890b7f48a57713a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Tissue Distribution
    168 rdf:type schema:DefinedTerm
    169 Nb66a5d31944046ecbce63296d535174a rdf:first sg:person.01362455574.53
    170 rdf:rest Nb89b1ca77ecf4479aea1e997e6bb936b
    171 Nb89b1ca77ecf4479aea1e997e6bb936b rdf:first sg:person.01341170162.48
    172 rdf:rest N9cf4c1364f3b40f496b7e9b4723c04d4
    173 Nc10740a18c54406094d55cac66fd1de7 schema:name pubmed_id
    174 schema:value 15258594
    175 rdf:type schema:PropertyValue
    176 Ne71dac92c2d94b35bcc1b3252fa88928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Prostatic Neoplasms
    178 rdf:type schema:DefinedTerm
    179 Ne83693c44fb34ee1b206fb2be32eaa8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Female
    181 rdf:type schema:DefinedTerm
    182 Ne8e3a9c0a40044cdb8a71339c427ba31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Microscopy, Fluorescence
    184 rdf:type schema:DefinedTerm
    185 Nefb346ce38a7435f84f8d8c8d84f534c schema:issueNumber 8
    186 rdf:type schema:PublicationIssue
    187 Nf49aa0e57d0d4407ab963502bfe22ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Materials Testing
    189 rdf:type schema:DefinedTerm
    190 Nfb59e9484caf47018aad969fdff06095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Neoplasms
    192 rdf:type schema:DefinedTerm
    193 Nfeda217bbb98433fbae9e22f57a78e9b schema:name readcube_id
    194 schema:value bca426598dd8271efb4f0d5ba45b815dc55c9631e0b50eebe465783d4498e737
    195 rdf:type schema:PropertyValue
    196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Medical and Health Sciences
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Oncology and Carcinogenesis
    201 rdf:type schema:DefinedTerm
    202 sg:grant.2435791 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt994
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.2437858 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt994
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2516430 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt994
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.7142868 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt994
    209 rdf:type schema:MonetaryGrant
    210 sg:journal.1115214 schema:issn 1087-0156
    211 1546-1696
    212 schema:name Nature Biotechnology
    213 rdf:type schema:Periodical
    214 sg:person.01142502201.76 schema:familyName Nie
    215 schema:givenName Shuming
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142502201.76
    217 rdf:type schema:Person
    218 sg:person.01256137310.20 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
    219 schema:familyName Gao
    220 schema:givenName Xiaohu
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256137310.20
    222 rdf:type schema:Person
    223 sg:person.01341170162.48 schema:familyName Chung
    224 schema:givenName Leland W K
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341170162.48
    226 rdf:type schema:Person
    227 sg:person.01362455574.53 schema:familyName Levenson
    228 schema:givenName Richard M
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362455574.53
    230 rdf:type schema:Person
    231 sg:pub.10.1007/s00330-002-1524-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075222288
    232 https://doi.org/10.1007/s00330-002-1524-x
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/383802a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009052486
    235 https://doi.org/10.1038/383802a0
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/74464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017554135
    238 https://doi.org/10.1038/74464
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/90228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012707267
    241 https://doi.org/10.1038/90228
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nature01663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036431452
    244 https://doi.org/10.1038/nature01663
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nbt0103-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019369675
    247 https://doi.org/10.1038/nbt0103-32
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nbt764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023895188
    250 https://doi.org/10.1038/nbt764
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nbt767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036950132
    253 https://doi.org/10.1038/nbt767
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nbt920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002851728
    256 https://doi.org/10.1038/nbt920
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nbt929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028221069
    259 https://doi.org/10.1038/nbt929
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nmat961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036730414
    262 https://doi.org/10.1038/nmat961
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nmat997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032148867
    265 https://doi.org/10.1038/nmat997
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nrd1088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010845241
    268 https://doi.org/10.1038/nrd1088
    269 rdf:type schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1075198228 schema:CreativeWork
    271 https://doi.org/10.1002/(sici)1521-3773(19981102)37:20<2754::aid-anie2754>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048587498
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/1521-3773(20011119)40:22<4128::aid-anie4128>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1044539382
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1006/bbrc.1995.2373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050172714
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0090-4295(00)01094-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005640176
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s0167-7799(03)00209-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006405196
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s0168-3659(01)00306-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006642632
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s0927-7765(99)00058-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014641728
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s0958-1669(02)00282-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006230504
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/s1074-7613(00)80149-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015646836
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/ac0354600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995595
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1021/bc015555d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153280
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1021/bc015563u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153287
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/bc034153y schema:sameAs https://app.dimensions.ai/details/publication/pub.1020647724
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/bi962148u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055212798
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1021/ja002535y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055717795
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1021/ja003486s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055725399
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1021/ja003633m schema:sameAs https://app.dimensions.ai/details/publication/pub.1007562638
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1021/ja021096v schema:sameAs https://app.dimensions.ai/details/publication/pub.1005973055
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1021/ja025946i schema:sameAs https://app.dimensions.ai/details/publication/pub.1055830704
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1021/ja035000o schema:sameAs https://app.dimensions.ai/details/publication/pub.1046129609
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1021/ja0361749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045211888
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1021/jp0308110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056052541
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1021/nl0155532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016049622
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1021/nl0347334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034740936
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.052029099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048311899
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.152463399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039713086
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.1735443100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022139285
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1097/01.ju.0000091655.77601.0c schema:sameAs https://app.dimensions.ai/details/publication/pub.1045587889
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1103/physrevlett.86.3132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060822831
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1109/3.64354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061149098
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1126/science.1077194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015841885
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1126/science.1078192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447105
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1126/science.1083780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036778978
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1126/science.1088525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023635206
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1126/science.271.5251.933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552242
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1126/science.278.5346.2114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018769951
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1126/science.281.5385.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018609686
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.281.5385.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006510768
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1146/annurev.bioeng.1.1.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044095591
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1162/15353500200302163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063350382
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1162/153535003765276282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063350382
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1177/002215540305100801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046364223
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1309/krnfwqqeuplql76l schema:sameAs https://app.dimensions.ai/details/publication/pub.1011755620
    356 rdf:type schema:CreativeWork
    357 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
    358 schema:name Department of Biomedical Engineering, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA.
    359 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...