Engineered riboregulators enable post-transcriptional control of gene expression View Full Text


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Article Info

DATE

2004-07

AUTHORS

Farren J Isaacs, Daniel J Dwyer, Chunming Ding, Dmitri D Pervouchine, Charles R Cantor, James J Collins

ABSTRACT

Recent studies have demonstrated the important enzymatic, structural and regulatory roles of RNA in the cell. Here we present a post-transcriptional regulation system in Escherichia coli that uses RNA to both silence and activate gene expression. We inserted a complementary cis sequence directly upstream of the ribosome binding site in a target gene. Upon transcription, this cis-repressive sequence causes a stem-loop structure to form at the 5'-untranslated region of the mRNA. The stem-loop structure interferes with ribosome binding, silencing gene expression. A small noncoding RNA that is expressed in trans targets the cis-repressed RNA with high specificity, causing an alteration in the stem-loop structure that activates expression. Such engineered riboregulators may lend insight into mechanistic actions of endogenous RNA-based processes and could serve as scalable components of biological networks, able to function with any promoter or gene to directly control gene expression. More... »

PAGES

841-847

Journal

TITLE

Nature Biotechnology

ISSUE

7

VOLUME

22

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt986

    DOI

    http://dx.doi.org/10.1038/nbt986

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040856976

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15208640


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