An engineered epigenetic transgene switch in mammalian cells View Full Text


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Article Info

DATE

2004-07

AUTHORS

Beat P Kramer, Alessandro Usseglio Viretta, Marie Daoud-El-Baba, Dominique Aubel, Wilfried Weber, Martin Fussenegger

ABSTRACT

In multicellular systems cell identity is imprinted by epigenetic regulation circuits, which determine the global transcriptome of adult cells in a cell phenotype-specific manner. By combining two repressors, which control each other's expression, we have developed a mammalian epigenetic circuitry able to switch between two stable transgene expression states after transient administration of two alternate drugs. Engineered Chinese hamster ovary cells (CHO-K1) showed toggle switch-specific expression profiles of a human glycoprotein in culture, as well as after microencapsulation and implantation into mice. Switch dynamics and expression stability could be predicted with mathematical models. Epigenetic transgene control through toggle switches is an important tool for engineering artificial gene networks in mammalian cells. More... »

PAGES

867-870

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt980

DOI

http://dx.doi.org/10.1038/nbt980

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042528786

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15184906


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