Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01

AUTHORS

Jonathan S Draper, Kath Smith, Paul Gokhale, Harry D Moore, Edna Maltby, Julie Johnson, Lorraine Meisner, Thomas P Zwaka, James A Thomson, Peter W Andrews

ABSTRACT

We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seen occasionally. This implies that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells. These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental. More... »

PAGES

53-54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt922

DOI

http://dx.doi.org/10.1038/nbt922

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005956847

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14661028


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