Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-12-07

AUTHORS

Sungjee Kim, Yong Taik Lim, Edward G Soltesz, Alec M De Grand, Jaihyoung Lee, Akira Nakayama, J Anthony Parker, Tomislav Mihaljevic, Rita G Laurence, Delphine M Dor, Lawrence H Cohn, Moungi G Bawendi, John V Frangioni

ABSTRACT

The use of near-infrared or infrared photons is a promising approach for biomedical imaging in living tissue1. This technology often requires exogenous contrast agents with combinations of hydrodynamic diameter, absorption, quantum yield and stability that are not possible with conventional organic fluorophores. Here we show that the fluorescence emission of type II2,3 quantum dots can be tuned into the near infrared while preserving absorption cross-section, and that a polydentate phosphine coating renders them soluble, disperse and stable in serum. We then demonstrate that these quantum dots allow a major cancer surgery, sentinel lymph node mapping4,5,6, to be performed in large animals under complete image guidance. Injection of only 400 pmol of near-infrared quantum dots permits sentinel lymph nodes 1 cm deep to be imaged easily in real time using excitation fluence rates of only 5 mW/cm2. Taken together, the chemical, optical and in vivo data presented in this study demonstrate the potential of near-infrared quantum dots for biomedical imaging. More... »

PAGES

93-97

Journal

TITLE

Nature Biotechnology

ISSUE

1

VOLUME

22

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt920

    DOI

    http://dx.doi.org/10.1038/nbt920

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002851728

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14661026


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    20 schema:description The use of near-infrared or infrared photons is a promising approach for biomedical imaging in living tissue1. This technology often requires exogenous contrast agents with combinations of hydrodynamic diameter, absorption, quantum yield and stability that are not possible with conventional organic fluorophores. Here we show that the fluorescence emission of type II2,3 quantum dots can be tuned into the near infrared while preserving absorption cross-section, and that a polydentate phosphine coating renders them soluble, disperse and stable in serum. We then demonstrate that these quantum dots allow a major cancer surgery, sentinel lymph node mapping4,5,6, to be performed in large animals under complete image guidance. Injection of only 400 pmol of near-infrared quantum dots permits sentinel lymph nodes 1 cm deep to be imaged easily in real time using excitation fluence rates of only 5 mW/cm2. Taken together, the chemical, optical and in vivo data presented in this study demonstrate the potential of near-infrared quantum dots for biomedical imaging.
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