Small-scale systems for in vivo drug delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10

AUTHORS

David A LaVan, Terry McGuire, Robert Langer

ABSTRACT

Recent developments in the application of micro- and nanosystems for drug administration include a diverse range of new materials and methods. New approaches include the on-demand activation of molecular interactions, novel diffusion-controlled delivery devices, nanostructured 'smart' surfaces and materials, and prospects for coupling drug delivery to sensors and implants. Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device. Current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary, the requirement for more stable sensor platforms, and the development of methods to evaluate these new materials and devices for safety and efficacy. More... »

PAGES

1184-1191

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  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    10

    VOLUME

    21

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt876

    DOI

    http://dx.doi.org/10.1038/nbt876

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031651380

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14520404


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