Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10

AUTHORS

Tiziano Barberi, Peter Klivenyi, Noel Y Calingasan, Hyojin Lee, Hibiki Kawamata, Kathleen Loonam, Anselme L Perrier, Juan Bruses, Maria E Rubio, Norbert Topf, Viviane Tabar, Neil L Harrison, M Flint Beal, Malcolm A S Moore, Lorenz Studer

ABSTRACT

Existing protocols for the neural differentiation of mouse embryonic stem (ES) cells require extended in vitro culture, yield variable differentiation results or are limited to the generation of selected neural subtypes. Here we provide a set of coculture conditions that allows rapid and efficient derivation of most central nervous system phenotypes. The fate of both fertilization- and nuclear transfer-derived ES (ntES) cells was directed selectively into neural stem cells, astrocytes, oligodendrocytes or neurons. Specific differentiation into gamma-aminobutyric acid (GABA), dopamine, serotonin or motor neurons was achieved by defining conditions to induce forebrain, midbrain, hindbrain and spinal cord identity. Neuronal function of ES cell-derived dopaminergic neurons was shown in vitro by electron microscopy, measurement of neurotransmitter release and intracellular recording. Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease. More... »

PAGES

1200-1207

Journal

TITLE

Nature Biotechnology

ISSUE

10

VOLUME

21

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt870

    DOI

    http://dx.doi.org/10.1038/nbt870

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052459824

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14502203


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