Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06-22

AUTHORS

Danwei Huangfu, René Maehr, Wenjun Guo, Astrid Eijkelenboom, Melinda Snitow, Alice E Chen, Douglas A Melton

ABSTRACT

Existing methods for reprogramming somatic cells to 'induced pluripotent stem cells' are inefficient, with only a small fraction of the starting cell population becoming pluripotent. Working with mouse embryonic fibroblasts, Hunagfu et al. increase reprogramming efficiency by treatment with DNA methyltransferase and histone deacetylase inhibitors.

PAGES

795-797

Journal

TITLE

Nature Biotechnology

ISSUE

7

VOLUME

26

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1418

    DOI

    http://dx.doi.org/10.1038/nbt1418

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014318073

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18568017


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