Ontology type: schema:ScholarlyArticle
2008-07
AUTHORSDanwei Huangfu, René Maehr, Wenjun Guo, Astrid Eijkelenboom, Melinda Snitow, Alice E Chen, Douglas A Melton
ABSTRACTReprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase (HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhibitor, improves reprogramming efficiency by more than 100-fold, using Oct4-GFP as a reporter. VPA also enables efficient induction of pluripotent stem cells without introduction of the oncogene c-Myc. More... »
PAGES795-797
http://scigraph.springernature.com/pub.10.1038/nbt1418
DOIhttp://dx.doi.org/10.1038/nbt1418
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18568017
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