Direct multiplexed measurement of gene expression with color-coded probe pairs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-03

AUTHORS

Gary K Geiss, Roger E Bumgarner, Brian Birditt, Timothy Dahl, Naeem Dowidar, Dwayne L Dunaway, H Perry Fell, Sean Ferree, Renee D George, Tammy Grogan, Jeffrey J James, Malini Maysuria, Jeffrey D Mitton, Paola Oliveri, Jennifer L Osborn, Tao Peng, Amber L Ratcliffe, Philippa J Webster, Eric H Davidson, Leroy Hood, Krassen Dimitrov

ABSTRACT

We describe a technology, the NanoString nCounter gene expression system, which captures and counts individual mRNA transcripts. Advantages over existing platforms include direct measurement of mRNA expression levels without enzymatic reactions or bias, sensitivity coupled with high multiplex capability, and digital readout. Experiments performed on 509 human genes yielded a replicate correlation coefficient of 0.999, a detection limit between 0.1 fM and 0.5 fM, and a linear dynamic range of over 500-fold. Comparison of the NanoString nCounter gene expression system with microarrays and TaqMan PCR demonstrated that the nCounter system is more sensitive than microarrays and similar in sensitivity to real-time PCR. Finally, a comparison of transcript levels for 21 genes across seven samples measured by the nCounter system and SYBR Green real-time PCR demonstrated similar patterns of gene expression at all transcript levels. More... »

PAGES

317-325

Journal

TITLE

Nature Biotechnology

ISSUE

3

VOLUME

26

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1385

    DOI

    http://dx.doi.org/10.1038/nbt1385

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053259870

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18278033


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