Genetic therapies against HIV View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

John J Rossi, Carl H June, Donald B Kohn

ABSTRACT

Highly active antiretroviral therapy prolongs the life of HIV-infected individuals, but it requires lifelong treatment and results in cumulative toxicities and viral-escape mutants. Gene therapy offers the promise of preventing progressive HIV infection by sustained interference with viral replication in the absence of chronic chemotherapy. Gene-targeting strategies are being developed with RNA-based agents, such as ribozymes, antisense, RNA aptamers and small interfering RNA, and protein-based agents, such as the mutant HIV Rev protein M10, fusion inhibitors and zinc-finger nucleases. Recent advances in T-cell-based strategies include gene-modified HIV-resistant T cells, lentiviral gene delivery, CD8(+) T cells, T bodies and engineered T-cell receptors. HIV-resistant hematopoietic stem cells have the potential to protect all cell types susceptible to HIV infection. The emergence of viral resistance can be addressed by therapies that use combinations of genetic agents and that inhibit both viral and host targets. Many of these strategies are being tested in ongoing and planned clinical trials. More... »

PAGES

1444-1454

References to SciGraph publications

  • 2005-12. CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection in RETROVIROLOGY
  • 2007-01. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load in NATURE MEDICINE
  • 2006-12. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/-(RAG-hu) mouse model in RETROVIROLOGY
  • 2005-07. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1 in GENE THERAPY
  • 2001-03. Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4 in GENE THERAPY
  • 2004-04. Insertional oncogenesis in gene therapy: how much of a risk? in GENE THERAPY
  • 2006-04. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 in NATURE MEDICINE
  • 2002-10. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice in LEUKEMIA
  • 2003-07. Immunopathogenesis and immunotherapy in AIDS virus infections in NATURE MEDICINE
  • 2005-09. Pioneering HIV treatment would use interference and gene therapy in NATURE
  • 2002-07. Lentiviral transduction of human T-lymphocytes with a RANTES intrakine inhibits human immunodeficiency virus type 1 infection in GENE THERAPY
  • 2002-04. Inhibition of HIV-1 replication by novel lentiviral vectors expressing transdominant Rev and HIV-1 env antisense in GENE THERAPY
  • 2007-02. Humanized mice in translational biomedical research in NATURE REVIEWS IMMUNOLOGY
  • 2004-02. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys in NATURE
  • 2002-07. Modulation of HIV-1 replication by RNA interference in NATURE
  • 2004-09. Unlocking the potential of the human genome with RNA interference in NATURE
  • 2007-11. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery in NATURE BIOTECHNOLOGY
  • 2002-01. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection in NATURE MEDICINE
  • 2002-05. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells in NATURE BIOTECHNOLOGY
  • 1996-11. The role of a mutant CCR5 allele in HIV–1 transmission and disease progression in NATURE MEDICINE
  • 2005-02. T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120 in GENE THERAPY
  • 1996-08. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene in NATURE
  • 2002-07. siRNA-directed inhibition of HIV-1 infection in NATURE MEDICINE
  • 2006-10. T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery in GENE THERAPY
  • 1986. Defective Interfering Viruses and Infections of Animals in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY
  • 2006-05. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways in NATURE
  • 1997-07. Gene therapy of T helper cells in HIV infection: Mathematical model of the criteria for clinical effect in BULLETIN OF MATHEMATICAL BIOLOGY
  • 1996-05. Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1367

    DOI

    http://dx.doi.org/10.1038/nbt1367

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18066041


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