Expression monitoring by hybridization to high-density oligonucleotide arrays View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-12

AUTHORS

D J Lockhart, H Dong, M C Byrne, M T Follettie, M V Gallo, M S Chee, M Mittmann, C Wang, M Kobayashi, H Horton, E L Brown

ABSTRACT

The human genome encodes approximately 100,000 different genes, and at least partial sequence information for nearly all will be available soon. Sequence information alone, however, is insufficient for a full understanding of gene function, expression, regulation, and splice-site variation. Because cellular processes are governed by the repertoire of expressed genes, and the levels and timing of expression, it is important to have experimental tools for the direct monitoring of large numbers of mRNAs in parallel. We have developed an approach that is based on hybridization to small, high-density arrays containing tens of thousands of synthetic oligonucleotides. The arrays are designed based on sequence information alone and are synthesized in situ using a combination of photolithography and oligonucleotide chemistry. RNAs present at a frequency of 1:300,000 are unambiguously detected, and detection is quantitative over more than three orders of magnitude. This approach provides a way to use directly the growing body of sequence information for highly parallel experimental investigations. Because of the combinatorial nature of the chemistry and the ability to synthesize small arrays containing hundreds of thousands of specifically chosen oligonucleotides, the method is readily scalable to the simultaneous monitoring of tens of thousands of genes. More... »

PAGES

1675

Journal

TITLE

Nature Biotechnology

ISSUE

13

VOLUME

14

Author Affiliations

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  • Methods And Compositions For Generation Of Multiple Copies Of Nucleic Acid Sequences And Methods Of Detection Thereof
  • Compositions And Methods In Cancer Associated With Altered Expression Of Kcnj9
  • Coupled Two-Way Clustering Analysis Of Data
  • Compositions And Methods In Cancer Associated With Altered Expression Of Prlr
  • Method And Computer Program Product For Reducing Fluorophore-Specific Bias
  • Treatment Of Amyotrophic Lateral Sclerosis Using Umbilical Derived Cells
  • Transcription Factors
  • Method For Making Populations Of Defined Nucleic Acid Molecules
  • Preparation Of Nucleic Acid Templates For Solid Phase Amplification
  • Compositions And Processes For Analyte Detection, Quantification And Amplification
  • Method Of Detecting Nucleic Acid By Using Dna Microarrays And Nucleic Acid Detection Apparatus
  • Biotin Containing C-Glycoside Nucleic Acid Labeling Compounds
  • Methods Of Synthesizing A Plurality Of Different Polymers On A Surface Of A Substrate
  • Identification And Use Of Molecular Markers Indicating Cellular Reprogramming
  • Nucleic Acid Labeling Compounds
  • Treatment Of Stroke And Other Acute Neural Degenerative Disorders Using Postpartum-Derived Cells
  • Characterization Of The Yeast Transcriptome
  • Method And Kit For Isolating Dna Probes That Bind To Activated Transcription Factors
  • Detection Of Human Umbilical Cord Tissue Derived Cells
  • Anti-Bv8 Antibodies And Uses Thereof
  • Nucleic Acid Labeling Compounds
  • 2-Aminopyrimidin-4-One Nucleic Acid Labeling Compounds
  • Method Of Testing Anticancer Agent-Sensitivity Of Tumor Cells
  • Method And/Or Apparatus Of Oligonucleotide Design And/Or Nucleic Acid Detection
  • Compositions For Amplification Of Rna Sequences Using Composite Primers
  • Methods Of Using Glucan Synthase Pathway Reporter Genes To Screen For Antifungal Compounds
  • Massively Parallel Single Cell Analysis
  • Diagnosis And Prognosis Of Breast Cancer Patients
  • Methods For Sterilizing Materials Containing Biologically Active Agents
  • Computer Systems And Methods For Providing Health Care
  • Method For Making Populations Of Defined Nucleic Acid Molecules
  • Identifiers

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